Shedding Light on Mutant Clonal Dynamics and Cancer Risk in the Skin
- 1 February 2021
- journal article
- editorial
- Published by American Association for Cancer Research (AACR) in Cancer Discovery
- Vol. 11 (2), 227-229
- https://doi.org/10.1158/2159-8290.cd-20-1644
Abstract
Summary: In this issue of Cancer Discovery, Fowler and colleagues conduct a thorough characterization of the dynamics of mutant clones in phenotypically normal human skin. Their results extend previous studies by showing that human skin is composed in large part of clones harboring mutations frequently observed in human cancer, while at the same time they uncover a previously unappreciated biological heterogeneity among nearby clones and across different body sites. See related article by Fowler et al., p. 340.Keywords
Funding Information
- VA Merit (1-I01-BX004495)
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