Treatment of narcolepsy with natalizumab
- 1 July 2020
- journal article
- letter
- Published by Oxford University Press (OUP) in Sleep
- Vol. 43 (7)
- https://doi.org/10.1093/sleep/zsaa050
Abstract
Researchers have hypothesized that narcolepsy type 1 (NT1) is caused by an autoimmune process since the 1990s, when narcolepsy was first found to be associated with the human leukocyte antigen (HLA) DQB1*06:02/DQA1*01:02 (DQ0602). In 2000, NT1 was discovered to be due to the selective loss of the hypocretin (HCRT, also known as orexin)-producing neurons in the hypothalamus [1–3]; and in 2010, Pandemrix, an H1N1 flu vaccine used in northern Europe, triggered numerous new cases of narcolepsy, further supporting an autoimmune trigger [4].Funding Information
- Wake Up Narcolepsy
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