The untapped potential of ascites in ovarian cancer research and treatment
Top Cited Papers
Open Access
- 7 July 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in British Journal of Cancer
- Vol. 123 (1), 9-16
- https://doi.org/10.1038/s41416-020-0875-x
Abstract
The build-up of fluid in the peritoneal cavity-ascites-is a hallmark of ovarian cancer, the most lethal of all gynaecological malignancies. This remarkable fluid, which contains a variety of cellular and acellular components, is known to contribute to patient morbidity and mortality by facilitating metastasis and contributing to chemoresistance, but remains largely under-researched. In this review, we will critically analyse the evidence associating ascites with metastasis and chemoresistance in ovarian cancer and provide an update on research in the field. We will argue the case for ascites as a unique and accessible substrate for tracking tumour progression and for translational research that will enhance our understanding of this cancer and lead to improvements in patient outcomes.Keywords
Funding Information
- Translational Cancer Research Network
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