Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging
Top Cited Papers
Open Access
- 7 August 2020
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Physiology
- Vol. 11, 963
- https://doi.org/10.3389/fphys.2020.00963
Abstract
Skeletal muscle fat infiltration (known as myosteatosis) is an ectopic fat depot that increases with aging and is recognized to negatively correlate with muscle mass, strength, and mobility and disrupt metabolism (insulin resistance, diabetes). An interdisciplinary workshop convened by the National Institute on Aging Division of Geriatrics and Clinical Gerontology on September 2018, discussed myosteatosis in the context of skeletal muscle function deficit (SMFD). Its purpose was to gain a better understanding of the roles of myosteatosis in aging muscles and metabolic disease, particularly its potential determinants and clinical consequences, and ways of properly assessing it. Special attention was given to functional status and standardization of measures of body composition (including the value of D3-creatine dilution method) and imaging approaches [including ways to better use dual-energy X-ray absorptiometry (DXA) through the shape and appearance modeling] to assess lean mass, sarcopenia, and myosteatosis. The workshop convened innovative new areas of scientific relevance to light such as the effect of circadian rhythms and clock disruption in skeletal muscle structure, function, metabolism, and potential contribution to increased myosteatosis. A muscle-bone interaction perspective compared mechanisms associated with myosteatosis and bone marrow adiposity. Potential preventive and therapeutic approaches highlighted ongoing work on physical activity, myostatin treatment, and calorie restriction. Myosteatosis’ impact on cancer survivors raised new possibilities to identify its role and to engage in cross-disciplinary collaboration. A wide range of research opportunities and challenges in planning for the most appropriate study design, interpretation, and translation of findings into clinical practice were discussed and are presented here.Keywords
This publication has 136 references indexed in Scilit:
- Longitudinal changes in total body creatine pool size and skeletal muscle mass using the D3‐creatine dilution methodJournal of Cachexia, Sarcopenia and Muscle, 2013
- CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistanceProceedings of the National Academy of Sciences of the United States of America, 2013
- Longitudinal changes in intermuscular fat volume and quadriceps muscle volume in the thighs of women with knee osteoarthritisArthritis Care & Research, 2011
- The Effect of Pioglitazone and Resistance Training on Body Composition in Older Men and Women Undergoing Hypocaloric Weight LossObesity, 2011
- Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin ResistanceCell Metabolism, 2010
- Epidemiology of myosteatosisCurrent Opinion in Clinical Nutrition and Metabolic Care, 2010
- Skeletal Muscle and Mortality Results From the InCHIANTI StudyThe Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 2009
- Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signalsProceedings of the National Academy of Sciences of the United States of America, 2007
- Aging in adipocytes: Potential impact of inherent, depot-specific mechanismsExperimental Gerontology, 2007
- Age, Gene/Environment Susceptibility-Reykjavik Study: Multidisciplinary Applied PhenomicsAmerican Journal of Epidemiology, 2007