B cells and tertiary lymphoid structures promote immunotherapy response
- 15 January 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 577 (7791), 549-555
- https://doi.org/10.1038/s41586-019-1922-8
Abstract
Treatment with immune checkpoint blockade (ICB) has revolutionized cancer therapy. Until now, predictive biomarkers1,2,3,4,5,6,7,8,9,10 and strategies to augment clinical response have largely focused on the T cell compartment. However, other immune subsets may also contribute to anti-tumour immunity11,12,13,14,15, although these have been less well-studied in ICB treatment16. A previously conducted neoadjuvant ICB trial in patients with melanoma showed via targeted...Keywords
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