The petroleum industry includes the global processes of exploration, extraction, refining, transportation and marketing of natural gas, crude oil and refined petroleum products. The oil industry demands more sophisticated methods for the exploitation of petroleum. As a result, the use of oil field chemicals is becoming increasingly important and has received much attention in recent years due to the vast role they play in the recovery of hydrocarbons which has enormous commercial benefits. The three main sectors of the petroleum industry are Upstream, Midstream and Downstream. The Upstream deals with exploration and the subsequent production (drilling of exploration wells to recover oil and gas). In the Midstream sector, petroleum produced is transported through pipelines as natural gas, crude oil, and natural gas liquids. Downstream sector is basically involved in the processing of the raw materials obtained from the Upstream sector. The operations comprises of refining of crude oil, processing and purifying of natural gas. Oil field chemicals offers exceptional applications in these sectors with wide range of applications in operations such as improved oil recovery, drilling optimization, corrosion protection, mud loss prevention, drilling fluid stabilization in high pressure and high temperature environment, and many others. Application of a wide range of oilfield chemicals is therefore essential to rectify issues and concerns which may arise from oil and gas operational activities. This review intends to highlight some of the oil field chemicals and their positive applications in the oil and gas Industries.