Efficacy of EPO on Treatment of Intrauter-ine Infection in Preterm Infants with Brain Injury

Abstract

目的：探讨促红细胞生成素(EPO)治疗宫内感染致早产儿脑损伤中的疗效。方法：选择2017年6月至2017年12月于我院产科分娩的早产儿96例，对孕母胎盘、胎膜行病理检查，确定是否存在宫内感染(绒毛膜羊膜炎)；采用ELISA法测定早产儿血清中细胞因子IL-1β、IL-6、TNF-α、IL-10水平；早产儿生后3~7天行颅脑MRI，通过头颅影像学表现判断是否存在脑损伤；筛选出存在宫内感染并脑损伤的患儿给予EPO治疗，2周后再次检测血清细胞因子水平。结果：1) 脑损伤发生率：胎盘病理诊断为绒毛膜羊膜炎组为67.5% (27/40例)，无感染组为16.1% (9/56例)，比较两组脑损伤发生率，差异有统计学意义(P Objective: To investigate the effect of postnatal EPO treatment on brain damage in premature infants caused by intrauterine infection. Methods: Ninety-six preterm infants delivered from June 2017 to December 2017 in our department of obstetrics were enrolled. The placenta of the pregnant mothers was examined for chorioamnionitis to determine whether there was intrau-terine infection. Enzyme-linked immunosorbent assay (ELISA) was used. The levels of cytokines IL-1β, IL-6, TNF-α, and IL-10 in serum of preterm infants were measured. Brain MRI was per-formed 3 - 7 days after birth in preterm infants. Brain imaging was performed to determine whether there was brain injury. Children with internal infection and brain injury were treated with EPO and serum cytokine levels were measured again after 2 weeks. Results: 1) The inci-dence of brain injury in children with placenta pathology diagnosed as chorioamnionitis was 67.5% (27/40 cases), and the prevalence of brain injury in non-chorionic amnion group was 16.1% (9/56 cases). The difference in prevalence was statistically significant (P