International Journal of Research in Dermatology

Journal Information
EISSN: 24554529
Published by: Medip Academy
Total articles ≅ 896

Latest articles in this journal

Dhiraj S. Dhoot, Namrata Mahadkar, Gaurav Jain, Prashant Kesharwani
Published: 6 December 2022
International Journal of Research in Dermatology; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20223279

Abstract:
Super-bioavailable itraconazole (SBITZ) is a new form of itraconazole which overcomes the pharmacokinetic issues of conventional itraconazole (CITZ). Currently two strengths are approved globally for SBITZ; 50 mg and 65 mg which exhibit greater bioavailability than CITZ and widely prescribed in systemic mycosis and dermatophytosis. Though both the strengths have proven to be bioequivalent with CITZ 100 mg but difference was reported in achieving therapeutic concentration of ITZ in patients. Secondly, skin kinetics study in terms of sebum concentration is lacking for both the strengths.
Noreen Munshi, Krishnendra Varma
Published: 15 November 2022
International Journal of Research in Dermatology; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20222997

Abstract:
Pseudoxanthoma elasticum (PXE) is a hereditary systemic connective tissue disease affecting mainly the skin, retina and cardiovascular system. Pathologically, it is characterized by mineralization and fragmentation of elastic fibers (so-called "elastorhexia"). PXE is associated with mutations in the ABCC6 (ATP binding cassette subtype C number 6) gene. Women are affected more than men. A 22-year-old woman came to our department with complaints of small, yellowish raised lesions in rows or lacy pattern on her neck since 2 years, some of which coalesced to form larger lesions. She also complains that the skin has been soft, flabby, and wrinkled since 2 years in the armpits, trunk, groin, and knees. On examination, the lesions were slightly pebbly in appearance; such papular lesions tend to coalesce gradually to form plaques with a cobblestone appearance. On histopathological examination, elastic fibers appear basophilic due to calcium deposition. The fibers were fragmented, swollen, and clustered in the middle and deep reticular dermis. The collagen fibers were split. Based on the above findings, a diagnosis of PXE was made. Due to the rarity of the disease, we are reporting this case. The course and prognosis were explained to the patient. Most of the pathological changes associated with PXE are irreversible, but prophylactic measures can be taken to minimize the course of the disease.
Noreen Munshi, Krishnendra Varma
Published: 15 November 2022
International Journal of Research in Dermatology; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20222980

Abstract:
Background: Objective of the research was to study the efficacy and safety of measles, mumps and rubella (MMR) vaccine in the treatment of warts.Methods: 53 patients with single or multiple warts in all age groups were included in the study. The patients received intralesional MMR vaccine 0.5ml into a single wart or the largest wart in case of multiple lesions at interval of 3 weeks for 3 treatments. All patients were followed up every 2 months up to 6 months regarding relapses. side effects and therapeutic outcomes were evaluated.Results: Out of 53 patients, 50 completed the study. Complete response was seen in 36 (72%), partial response in 09 (18%) and no response in 05 (10%) patients. 3 out of 36 patients with complete response were having recurrence of warts. Pain at the site of injection and flu like symptoms were the main side effects observed.Conclusions: Intralesional immunotherapy with MMR vaccine was found to be a simple, effective, and safe treatment for warts. This study proved to be cost effective as patients can be treated with just 03 doses of MMR vaccine given at the interval of three weeks.
L. Satyanka, K. V. T. Gopal, P. V. Krishnam Raju, B. Rekha Rani
Published: 27 October 2022
International Journal of Research in Dermatology, Volume 8, pp 585-588; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20222733

Abstract:
Sarcoidosis/Mortimer’s malady is a multisystem disease defined by presence of epithelioid cell granulomas without caseation in various organs.It involves mainly the lungs, eyes, skin, lymph node etc. We reported a 40 year old female who presented with multiple plaques over different regions of the body with past history of ulcerated lesion of scalp which healed with cicatricial alopecia. On thorough evaluation she was found to have involvement of multiple internal organs. Based on the clinical features and histopathological findings, a diagnosis of cutaneous sarcoidosis (plaque type) was made. Patient treated with systemic and topical corticosteroids resulting in marked improvement in her skin lesions were seen and pulmonary complaints also resolved.
Phyo Zaw Aung, Pacharee Simsamer, Thamthiwat Nararatwanchai
Published: 27 October 2022
International Journal of Research in Dermatology, Volume 8, pp 564-567; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20222727

Abstract:
A 61-year-old man with a history of thyrotoxicosis, diabetes mellitus, hypertension, and dyslipidemia presented to the dermatology outpatient clinic with bilateral non-pitting edema, asymmetrical yellowish-brown plaques, and nodules associated with some areas of hyperpigmentation, Peau’d orange appearance and elephantiasis-like skin lesions over both low legs. It was diagnosed as pretibial myxedema attributed to thyrotoxicosis. Additionally, convoluted folds and deep furrows similar to the cerebral cortical surface were seen on the forehead suggesting secondary cutis verticis gyrata (CVG) and our approach to the patient will be discussed in this case report.
Mrudula Pulletikurti, K. V. T. Gopal, P. V. Krishnam Raju, B. Rekha Rani
Published: 27 October 2022
International Journal of Research in Dermatology, Volume 8, pp 581-584; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20222732

Abstract:
Bullous SLE is an uncommon complication of SLE with autoantibodies to type VII collagen of dermo-epidermal junction. We report a 31-year-old female who presented with vesiculobullous lesions in the photo exposed areas along with vasculitic lesions over palms and soles and ulcerations in the larynx. She also had history of photosensitivity and hair loss. Investigations showed significant anaemia and high titres of antibodies (ANA, anti-ds-DNA, anti Sm) confirming SLE. Histopathology showing sub epidermal blister with neutrophils and immunofluorescence favoured diagnosis of bullous SLE. The patient responded well to high dose parenteral steroids and dapsone. In view of high probability of renal involvement, patient was referred to nephrologist and is under regular follow up.
Vrushali Raju Nandkule, Pratiksha Harishchandra More, Shailee Shelke, Rutuja Raju Nandkule, Yogita Uttam Landge
Published: 27 October 2022
International Journal of Research in Dermatology, Volume 8, pp 571-573; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20222729

Abstract:
Formocresol is widely used in pediatric endodontics as a pulpotomy medicament. Formocresol helps to fix soft tissues in oral cavity such as pulp. Care should be taken while using formocresol proper isolation techniques should be used during its application as an endodontic material, because of its hazardous effects on soft tissue. This article elaborates the case of chemical burns due to improper handling of formocresol during dental treatment. It demonstrates the underlying effect such as moderate pain burning sensation and patchy dark discoloration of skin and its resolution.
Carly J. Robinson, Neil K. Jairath, Jon C. Davis, Hongyu H. Yang
Published: 27 October 2022
International Journal of Research in Dermatology, Volume 8, pp 574-577; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20222730

Abstract:
Drug-induced cutaneous vasculitis is a known autoimmune complication of tumor necrosis factor (TNF) inhibitors with many instances resulting in the production of newly formed antibodies. We report a 21-year-old female with a past medical history of Crohn’s disease controlled with infliximab who presented to dermatology with a purpuric rash and crusted plaques of her distal lower extremities. Biopsy of a lesion revealed perivascular lymphocytes, neutrophils and eosinophils, vessel wall damage, and dermal eosinophils consistent with a drug-induced vasculitis. Follow up labs assessing for antibodies revealed unusual findings of an elevated cytoplasmic-antineutrophil cytoplasmic autoantibody (C-ANCA) titer and myeloperoxidase (MPO) antibody level making this patient MPO-C-ANCA positive. The patient’s lesions were treated with both oral and topical steroids, colchicine, and transition of her infliximab to ustekinumab with subsequent improvement of her lesions and normalization of antibody titers.
Guneet Bedi, Pratisha Dash
Published: 27 October 2022
International Journal of Research in Dermatology, Volume 8, pp 543-550; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20222725

Abstract:
Background: Eczema, also known as dermatitis, is characterized by skin inflammation, which presents as pruritus, skin dryness and erythema. Soteri cream, which was used in the study, contains Helianthus annus oil, glycerin, sodium hyaluronate, niacinamide and various ceramides. Niacinamide upregulates epidermal ceramide synthesis; thereby, strengthening epidermal barrier.Methods: The study was conducted on 30 patients in total, out of which, 5 patients were of scalp (3) and palmar psoriasis (2), 10 of eczema, 10 of atopic dermatitis and 5 of rosacea. The above patients were the ones coming to Aayna clinic for their respective skin concerns. After doing clinical examination and taking written consent, patients were given Soteri skin cream, to apply twice daily on the area of concern. Follow up was done fortnightly for a month. Patient’s assessment in follow up visits was done with clinical photographic, along with dermoscopic photographic assessment after a month and by filling proforma for effects and side effects using VAS and SCORAD score (for atopic dermatitis).Results: Complete symptomatic and visual improvement was seen in 3 patients of eczema, 2 of rosacea, 1 of scalp psoriasis and 6 of atopic dermatitis.Conclusions: Soteri skin cream with its unique formulation of ceramides and niacinamide resulted in significant improvement in psoriasis, hand and nummular eczema, atopic dermatitis and rosacea. It is a steroid free, valuable line of treatment for chronic eczema.
Ravina R. Naik, Pankaj Shukla
Published: 27 October 2022
International Journal of Research in Dermatology, Volume 8, pp 535-542; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20222724

Abstract:
Background: Patterned hair loss is one of the commonest conditions for which both men and women seek dermatologist. Though term androgenetic alopecia is used synonymously for female pattern hair loss, role of androgens and other hormones in its causation remains controversial. Also, in literature few studies are present suggesting role of trichoscopy in female pattern hair loss. We sought to investigate role of endocrine disturbances and trichoscopic findings in female pattern hair loss as per Ludwig classification.Methods: This was a prospective case control study. 100 cases and 100 age matched controls were enrolled in study. Laboratory investigations were done in both groups and trichoscopic examination was done in cases, at frontal and occipital scalp. The data was analyzed using t test, McNemar test and as mean, standard deviation and as percentages.Results: The difference between the mean value of body mass index, hemoglobin, T4, prolactin, follicle stimulating hormone, testosterone and dehydroepiandrosterone were found to be statistically significant as compared to controls. On trichoscopy, hair diameter diversity was commonest findings, however focal atrichia, 2-3 hairs/hair unit, white dots, honey comb pigmentation (HCP) correlated with grade of hair loss.Conclusions: Our study supports role of hormonal disturbances in causation of female pattern hair loss and thus we recommend doing tests in early onset and severe degrees of hair loss. Though diagnosis is mainly clinical trichoscopy could be excellent tool which is simple, non-invasive and cost-effective tool and may help to differentiate Female patterned hair loss from other condition like chronic telogen effluvium.
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