Journal Information
ISSN / EISSN: 21612129 / 21507511
Total articles ≅ 6,273

Latest articles in this journal

Pratima Saini, Opeyemi S. Adeniji, Devivasha Bordoloi, Jennifer Kinslow, Jeff Martinson, Danielle M. Parent, Kai Ying Hong, Jane Koshy, Abhijeet J. Kulkarni, Netanel F. Zilberstein, et al.
Published: 2 February 2023
Journal: Mbio
Abstract:
One mechanism that cancer cells use to evade natural killer cell immune surveillance is by expressing high levels of sialoglycans, which bind to Siglec-9, a glyco-immune checkpoint molecule on NK cells. This binding inhibits NK cell cytotoxicity.
Published: 1 February 2023
Journal: Mbio
Abstract:
Understanding why antibiotics sometimes fail to cure infections is fundamental to improving treatment outcomes. This is a major challenge when it comes to Staphylococcus aureus because this pathogen causes several different chronic or recurrent infections.
Marianna E. Akey, Rui Xu, Soumya Ravindran, Lisa Funkhouser-Jones,
Published: 1 February 2023
Journal: Mbio
Abstract:
Although Cryptosporidium is extremely efficient at penetrating mucus and invading epithelial cells in the intestine, the mechanism of cell attachment is poorly understood. To expand our understanding of this process, we characterized the antigens recognized by a monoclonal antibody that stains the apical end of invasive stages called sporozoites and merozoites.
, S. D. W. Frost, N. K. Nguyen, , A. R. Place, K. K. Treseder
Published: 1 February 2023
Journal: Mbio
Abstract:
Climate change is a complex problem involving nonlinearities and feedback that operate across scales. No single discipline or way of thinking can effectively address the climate crisis.
Andrew Cheng, Danny Wan, Arkaprabha Ghatak, Chengyuan Wang, Deyu Feng, Joseph D. Fondell, ,
Published: 31 January 2023
Journal: Mbio
Abstract:
Chlamydiae are obligate intracellular bacteria that replicate only inside eukaryotic cells. Previously, it has not been possible to identify a candidate gene encoding the chlamydial RNA polymerase ω subunit, and it has been hypothesized that the chlamydial RNA polymerase ω subunit was lost in the evolutionary process through which Chlamydiae reduced their genome size and proteome sizes to adapt to an obligate intracellular lifestyle.
Xian Xiao, Manuel Delgado-Baquerizo, Haoyang Shen, Zhiyuan Ma, Jizhong Zhou, Bo Sun,
Published: 31 January 2023
Journal: Mbio
Abstract:
Soil microorganisms drive emissions of nitrous oxide from soils; this is a powerful greenhouse gas and the dominant ozone-depleting agent. N 2 O emissions can be partly predicted from soil properties and specific microbial groups, whereas a possible role of below-ground microbial interactions has largely been overlooked.
Kang Ning, Cagla Aksu Kuz, Fang Cheng, Zehua Feng, Ziying Yan,
Published: 31 January 2023
Journal: Mbio
Abstract:
Recombinant AAV (rAAV) has emerged as one of the preferred delivery vectors for clinical gene therapy. rAAV production in HEK293 cells by transfection of a rAAV transgene plasmid, an AAV Rep and Cap expression packaging plasmid, and an Ad helper plasmid remains the popular method. Here, we demonstrated that the high fidelity Y family DNA repair DNA polymerase, Pol η, and Pol κ, plays a significant role in AAV DNA replication and rAAV production in HEK293T cells.
Vadim Dubinsky, Iris Dotan,
Published: 31 January 2023
Journal: Mbio
Abstract:
By reconstructing bacterial genomes from samples taken from specific sites within the human intestines, via aspiration, we show that strains at specific intestinal sites are genetically distinct yet interrelated and are derived from a single founder population. Organ-specific metagenomic information represents a powerful tool to generate insights into gastrointestinal diseases, which involve only a part of the intestine, such as inflammatory bowel disease.
Emi Hashizaki, Miwa Sasai, , Tsubasa Nishi, Takashi Kobayashi, Shiroh Iwanaga,
Published: 30 January 2023
Journal: Mbio
Abstract:
The parasite Toxoplasma gondii has a counterdefense system against interferon-γ (IFN-γ)-dependent host immunity which relies on the secretion of parasite effector proteins. ROP18 is one of the effector, which is released into host cells to inactivate IFN-γ-dependent anti- Toxoplasma host proteins. The mechanism by which Toxoplasma ROP18 subverts host immunity has been extensively analyzed, but how Toxoplasma produces this virulence factor remains unclear.
Anastasiia Driuchina, Jukka Hintikka, Marko Lehtonen, Pekka Keski-Rahkonen, Thomas O’Connell, Risto Juvonen, Juho Kuula, Antti Hakkarainen, Jari A. Laukkanen, Elina Mäkinen, et al.
Published: 30 January 2023
Journal: Mbio
Abstract:
Because the high prevalence of nonalcoholic fatty liver disease sets diagnostic challenges to health care, identification of new biomarkers of the disease that in the future could have potential utility as diagnostic biomarkers of high liver fat content is important. Our results show that increased amino acid degradation products in the feces may be such biomarkers.
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