Open Journal of Tropical Medicine

Journal Information
EISSN: 26408147
Total articles ≅ 22

Latest articles in this journal

Sidorkevich Sergey, Kasyanov Andrey, Glazanova Tatiana, Abramovsky Stanislav, Bessmeltsev Stanislav
Published: 31 December 2022
Open Journal of Tropical Medicine, Volume 6, pp 011-015; https://doi.org/10.17352/ojtm.000022

Abstract:
Introduction: Platelet concentrates (PC) are among the most needed blood components used to correct thrombocytopenia of various origins. The main problems in transfusion therapy are the risks of infectious complications associated with the limited shelf life of platelet concentrates at storage. The article presents the results of a comparative analysis of the quality parameters of apheresis platelet concentrate prepared on two additional solutions: experimental additional solution (ASexp) containing sodium fumarate and SSP+ solution. Objective: To perform a comparative analysis of quality parameters, metabolic rate, hemostatic ability, and markers of activation and apoptosis of platelets (15 units) prepared on an experimental additional solution containing sodium fumarate and on an additional SSP+ solution for prolonged storage periods (15 days) at a temperature of 4 °C ± 2 °C. Materials and methods: We have studied the parameters of the thrombography, metabolism, hemostatic potential, markers of activation, and apoptosis for prolonged periods (15 days) of storage at a temperature of 4 °C ± 2 °C. Results: The results of the study indicate that during prolonged cold storage (15 days), there is a slight decrease in the number of platelets, a decrease in the level of metabolism, and significant morphofunctional changes occur both when using SSP+ and ASexp additional solutions. At the same time, hemostatic activity remains at a fairly high level throughout the entire storage period. The results of the analysis for most of the studied parameters did not reveal significant differences between the groups. At the same time, the parameters mandatory for quality control and safety met the standard values by the end of the observation period. Conclusion: Our data indicate the possibility of using the developed additional solution based on sodium fumarate for storing platelets at a temperature of +4 °C ± 2 °C for 15 days.
Achere Eyong Clinton, Ndifontiayong Adamu Ndongho, Ntungwen Fokunang Charles, Shey Nsagha Dickson
Published: 7 November 2022
Open Journal of Tropical Medicine, Volume 6, pp 001-010; https://doi.org/10.17352/ojtm.000021

Abstract:
Background: Malaria parasitemia and HIV infections are globally important public health concerns. People residing in regions where these two infections are endemic are prone to develop co-infection. Sub-Saharan Africa has the greatest burden of both diseases and Cameroon particularly the South West Region has been reported as one of the regions with the highest malaria and HIV prevalence. Hence, there is a need for continuous monitoring and epidemiologic inquiry to generate updated data on the burden of malaria parasitemia on HIV/AIDS. The aim of this study was to determine the prevalence of malaria parasitemia and the association between viral load and malaria parasite density in people living with HIV/AIDS in Kumba, Cameroon. Methods: A cross-sectional study was conducted involving 250 people living with HIV/AIDS selected from five main Community Based Organizations in Kumba during a period of 5 months from April to August 2021. Participants’ consent was obtained followed by socio-demographic and other useful data via a standardized questionnaire. Capillary blood samples were collected and Giemsa-stained blood films were examined to detect malaria parasitemia. The recent viral loads were collected from the participants’ medical files. Pearson’s chi-square was used for the comparison of proportions and correlation analysis to determine the association between parasite density and viral load. Statistical significance was set at p < 0.05. Results: An overall prevalence of malaria parasitemia in people living with HIV/AIDS in Kumba was 27.2%; [95% CI: 21.8% – 33.2%]. Among 215 participants who were HAART-experienced, 49(22.79%); [95% CI: 17.6% – 27.9%] were found to be positive for malaria parasitemia while 19(54.29%); [95% CI: 48.1% – 60.5%] out of the 35 HAART naïve individuals were positive for malaria parasitemia. This difference in prevalence was statistically significant (X2 = 15.078, df = 1, N = 250, p < 0.000). Also, malaria parasite density was significantly dependent on viral load (X2 = 61.065, df = 6, N = 49, p < 0.000). HAART-experienced participants with high viral load(>1000copies/ml) had significantly higher malaria parasite density(>400trophozoites/µL) than HAART-experienced participants with ‘not detectable’ viral load. Conclusion: The prevalence of malaria parasitemia in the study population was 27.2%. HAART naïve individuals had significantly higher malaria parasitemia prevalence and malaria parasite density than HAART-experienced individuals. Malaria parasite density was significantly dependent on viral load in HAART-experienced individuals.
, Pino Luis Eduardo, Cruz Denisse Rubio
Open Journal of Tropical Medicine, Volume 5, pp 003-009; https://doi.org/10.17352/ojtm.000019

, Vangveeravong Mukda
Published: 27 January 2021
Open Journal of Tropical Medicine, Volume 5, pp 001-002; https://doi.org/10.17352/ojtm.000018

Marquetti Fernandez Maria del Carmen, Marquetti Andres Bisset
Open Journal of Tropical Medicine, Volume 4, pp 020-022; https://doi.org/10.17352/ojtm.000015

, Trres Carlos M, Alvarez Mayling, Martinez Pedro A, Calzada Naifi, Garcia Lianna M, Guzman Maria G
Open Journal of Tropical Medicine, Volume 4, pp 007-014; https://doi.org/10.17352/ojtm.000013

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