Bioinspired, Biomimetic and Nanobiomaterials

Journal Information
ISSN / EISSN: 20459858 / 20459866
Published by: Thomas Telford Ltd.
Total articles ≅ 280

Latest articles in this journal

Nimra Sadar, Atif Yaqub, Sarwar Allah Ditta
Bioinspired, Biomimetic and Nanobiomaterials pp 1-12; https://doi.org/10.1680/jbibn.21.00068

Abstract:
Iron oxide nanoparticles (NPs) have recently attracted wider attention because of their unique properties, such as superparamagnetism, larger surface area, surface-to-volume ratio, and simple manufacturing process. Several chemical, physical, and biological techniques have been employed to synthesize NPs with admissible surface chemistry. This paper summarises the approaches for producing iron oxide NPs, shape, and size management, and inviting properties in bioengineering, pharmaceutical, and modern applications. Iron oxides have significant potential in biology, climate change, and horticulture, among other fields. Surface coatings with organic or inorganic particles are one of a kind. The surface coatings of the IONPs are critical to their performance because they prevent nanoparticle aggregation, reduce the risk of immunogenicity, and limit nonspecific cellular uptake. Chitosan is a biodegradable polymer that is applied to iron oxide nanoparticles to coat them. Chitosan subordinates like O-HTCC (an ammonium-quaternary CS subsidiary) have a long-lasting positive charge that allows them to work in different pH ranges allowing their interactions with cell layers at physiological pH. By reacting epoxy propyl trimethyl ammonium chloride (ETA) with chitosan (CS), the hydro-solvent N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride (HTCC) is formed. For hyperthermic treatment of patients, NPs can also be coordinated to an organ, tissue, or tumor via an external attractive field. Given the increasing interest in iron NPs, the purpose of this review is to present data from iron oxide nanoparticles specially chitosan-capped iron NPs for different biomedical fields.
Muhammad Sher, Muhammad Ajaz Hussain, Arooj Fatima, Muhammad Naeem-Ul-Hassan, Maqsood Ahmed, Syed Nasir Abbas Bukhari
Bioinspired, Biomimetic and Nanobiomaterials pp 1-15; https://doi.org/10.1680/jbibn.21.00065

Abstract:
The aim of this study was to develop solid dispersions (SDs) of Clarithromycin (CLA) using hydrophilic polymer hydroxypropyl- methylcellulose (HPMC) and Xanthan Gum (XNG) as drug carrier. The in vitro dissolution study was performed in dissolution media of pH 6.8 and compared with that of standard drugs. In vivo pharmacokinetic studies were carried out on animal model (rabbits).The thermal behavior of each SDs formulation was studied by differential scanning calorimetry (DSC) analysis. The results concluded that crystalline nature of CLA has been transformed to amorphous form in SDs. Pharmacokinetic parameters were observed to be improved in HPMC as well as XNG based SDs than that of standard drugs. Additionally, powder X-ray diffraction (PXRD) analysis also confirmed the phase transition (crystalline to amorphous) of drug present in SDs. The higher values of Cmax, were found in case of HPMC based SDs, whereas, tmax values were prolonged in SDs based on XNG. Additionally, enhanced half-life values predicted that SDs would have potential to achieve once daily dose and improved patient compliance of drugs. Hence, the formulated SDs of poorly soluble drug, based on HPMC and XNG as carriers, exhibited more hydrophilic nature with enhanced aqueous solubility and therefore improved bioavailability as compared to that of standard drug.
Sabere Sabere NourixSearch for articles by this authorDepartment of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran Fatemeh Yousef-SaberxSearch for articles by this authorDepartment , Fatemeh Yousef-Saber, Giti Emtiazi, Neda Habibi, Appala Raju Badireddy, Stella M. Marinakos, Shankararaman Chellam, Mark R. Wiesner, Avilés Amarillys, Hernandez Claralys, et al.
Bioinspired, Biomimetic and Nanobiomaterials pp 1-13; https://doi.org/10.1680/jbibn.21.00064

Abstract:
The unique physicochemical properties of nano-metals compared with those of non-nanomaterials have led to many investigations in recent decades. Nano-titanium dioxide has been chiefly applied in novel implant forms. Also, the structures of selenium-containing compounds play a critical role in the biological activity of these elements. According to recent studies, nano-selenium is not only less toxic, but also has a higher biological activity than selenium ions such as selenium (IV) (Se4+) and selenium (VI) (Se6+). Researchers have turned to green nanostructure synthesis due to the drawbacks of chemical techniques. This paper presents a literature review on recent advances in microbial synthesis methods for producing nano-selenium and nano-titanium dioxide. Despite numerous research articles on green nanoparticle production, little information has been provided on the microbial formation of titanium and selenium nanoparticles. This review paper focuses on the possible mechanism of nano-selenium production by selenium respiration. Although there are reports of microbial synthesis of these particles, their production by probiotic bacteria is of great value. Considering the compatibility of probiotic bacteria with the immune system and their tremendous applications in medicine, it is suggested to use them in combination with nano-titanium dioxide and nano-selenium for various ends such as implant scaffolds and food additives, respectively.
Mansour Mansour BinandehxSearch for articles by this authorFaculty of Science, Department of Chemistry and Biotechnology, University of Maragheh, Iran, Shuang Liang, Götz Veser, El-Kaliuoby Mai Ismail, El-Khatib Ahmed Mohamed, Khalil Alaa Mahmoud, Konstantin Vogel, Nina Westphal, Dirk Salz, Karsten Thiel, et al.
Published: 20 December 2022
Bioinspired, Biomimetic and Nanobiomaterials pp 1-7; https://doi.org/10.1680/jbibn.21.00066

Abstract:
Magnetic nanoparticles (MNPs) are the main source of synthesis and design of magnetic nanocatalysts, which are obtained from iron salts through the chemical coprecipitation method. The main goal of this research is to investigate the absorption, release and antibacterial properties of magnetic nanocatalysts with silica coating and silica/amine linkers. The structure of the obtained nanocatalyst can be detected through scanning electron microscopy, transmission electron miroscopy, energy-dispersive X-ray spectroscopy and infrared spectroscopy. There is a reaction between ampicillin (10 μl, 25 μg/ml) and Fe3O4@SiO2 and Fe3O4@SiO2/NH2 magnetic nanocatalysts (200 mg, 2 mol%) at 25°C and in double-distilled water. In this way, the amount of absorbed ampicillin on the [email protected]/amine structure in covalent form is higher than that on the [email protected] structure in non-covalent bonding form – namely, 85 to 65%. The rate of release in non-covalent form is above 90%, whereas in covalent form, it is less than 80%. Additionally, the bactericidal activity of nanocatalysts tested separately at a temperature of 37°C for the non-covalent type is 80% compared with that of the covalent type, which is 70%. The overall result was that the percentage efficiency of the absorption/release reaction in the non-covalent bonding state was 10% more than that for the non-covalent bonding state.
Farzad Bamdad, Farnaz Kazemzadeh
Published: 23 September 2022
Bioinspired, Biomimetic and Nanobiomaterials pp 1-7; https://doi.org/10.1680/jbibn.21.00056

Abstract:
Captopril is an angiotensin-converting enzyme commonly used to treat high blood pressure and to improve survival after a heart attack. Considering the importance of the assay of this drug, we have proposed a simple and cost-effective colorimetric technique for the quantitative determination of it. The detection strategy was based on the redshift of the surface plasmon resonance band of silver nanoparticles (AgNps) induced by the action of captopril molecules. Under optimal experimental conditions, the interaction of AgNPs with captopril molecules in the presence of barium ions motivates the aggregation of AgNPs. The final result of this process is an observable change in the color of the tested solution from pale yellow to light brown. Our experiments showed that there is a linear relationship between the absorbance of AgNps solution and captopril concentration at about 720 nm, thus it is possible to assay the captopril amount just by measuring the absorbance of the examined solution at this wavelength. The calibration curve was linear in the range of 1.0 to 6.0 μM captopril with a detection limit equal to 0.4 μM. The proposed strategy was successfully applied to the determination of captopril in pharmaceutical preparations.
Bjorn John Stephen, Ankit Chokriwal, Madan Mohan Sharma, Devendra Jain, Juhi Saxena, Harshdeep Dhaliwal, Vikram Sharma, Rajeev Mishra, RamanDeep Kaur, Abhijeet Singh
Published: 23 September 2022
Bioinspired, Biomimetic and Nanobiomaterials pp 1-13; https://doi.org/10.1680/jbibn.21.00059

Abstract:
Neuroinflammation is a condition that contribute significantly to the pathogenesis and progression of several neurodegenerative disorders. Targeting neuroinflammation is a novel therapeutic approach for the treatment of these disorders. Dexamethasone is a steroidal based anti-inflammatory drug with the potential to treat neuroinflammation. However, in order to maintain the efficacy of the drug, dexamethasone needs to be coupled with an effective drug delivery vehicle to be able to be transported across Central Nervous System. PLGA nanoparticles has been used as drug delivery vehicles for transport of drugs into the central nervous system. The article describes the preparation and encapsulation of dexamethasone loaded PLGA nanoparticles by solvent evaporation method. Statistical Experimental Design approach was performed, wherein Response Surface Methodology was carried out to optimize the parameters associated with synthesis process. Further, kinetic modeling and drug release profile were also determined. The drug encapsulated nanoparticles were validated for its effectiveness in vitro. Toxicity studies revealed the nanodrug to be non-cytotoxic and Griess assay highlighted its ability to lower neuroinflammation. Further, genetic studies revealed the anti-inflammatory properties of the nanodrug was successfully in modulating neuroinflammation.
Niyousha Niyousha YazdanmehrxSearch for articles by this authorDepartment of Mechanical Engineering, University of Ottawa, Ottawa, Ontario, Canada Maryam TajabadixSearch for articles by this authorSchool of Metallurgy and Materials Engineering, Iran University of , Maryam Tajabadi, Razieh Bigdeli, Hanif Goran Orimi, , Dorota Matyszewska, Ijaz Hira, Qureshi Junaid, Tulain Ume Ruqia, Iqbal Furqan, et al.
Published: 1 September 2022
Bioinspired, Biomimetic and Nanobiomaterials, Volume 11, pp 111-120; https://doi.org/10.1680/jbibn.21.00053

Abstract:
Biological barriers could be overcome using nanobiotechnology, which promotes the development of nanomaterial-based delivery systems. The primary objective of the present investigation is superparamagnetic iron oxide nanoparticle (SPION) production for the delivery of topotecan to human breast cancer cells (MCF-7). The X-ray diffraction results confirmed the formation of pure SPIONs. The Fourier transform infrared spectra indicated the functional groups related to aminopropyl trimethoxy silane as a coating agent and topotecan. Topotecan-loaded magnetite nanoparticles with an IC50 of approximately 156 μg/ml exhibited dose-dependent cytotoxicity. The polymerase chain reaction method also proved that in the mentioned cell line, topotecan-loaded SPIONs could increase the Bax/Bcl-2 ratio and p53 gene expression. An annexin V/propidium iodide detection assay was done to detect the induction of apoptosis. According to the results, the nanoparticles inhibit the survival of MCF-7 breast cancer cells by boosting apoptosis, which helps slow the growth of tumor cells.
Melissa Anahí Olvera Carreño, ,
Published: 1 September 2022
Bioinspired, Biomimetic and Nanobiomaterials, Volume 11, pp 86-100; https://doi.org/10.1680/jbibn.22.00027

Abstract:
Several natural materials have demonstrated excellent mechanical performance and have abundant resources and friendly chemistry. Additionally, these materials have evolved to have optimized weight and maximized strength and energy absorption at the macro-, micro- and nanostructural levels. However, engineers still face challenges regarding the same issues. Therefore, this paper aims to identify the current literature on structural materials and their manufacturing methods. In this regard, a review was conducted to assess the extent of the literature in local databases through a research question and Boolean operators. The results were classified into four main categories, plastic, metals, ceramic composite materials and organism-oriented structural materials, and their mechanical properties (energy absorption, fracture toughness, stiffness) are discussed. The results of this study can be generalized and easily comprehended by scientists, innovators, researchers and the public. This review discusses structural materials for which enhancement of mechanical properties is of vital importance. Finally, this study illustrates how bioinspiration provides a powerful tool for tuning the mechanical properties of diverse materials through structural arrangement with no significant modification to the composition of the constituent materials. Moreover, it addresses trends in manufacturing processing routes and their scalability to drive further innovation in the field.
Kaijie Kaijie ZhangxSearch for articles by this authorSchool of Materials Science and Engineering, Shandong University of Technology, Shandong, P.R. China Xiangyu ZhangxSearch for articles by this authorSchool of Materials Science and Engineering, Shandong Unive, Xiangyu Zhang, Haibin Sun, Xiaowei Li, Jiahai Bai, Qingyang Du, Chengfeng Li, Banerjee Pradipta, Das Jayashree, Tripathi Shuchita, et al.
Published: 1 September 2022
Bioinspired, Biomimetic and Nanobiomaterials, Volume 11, pp 101-110; https://doi.org/10.1680/jbibn.21.00011

Abstract:
Biocompatible hydroxyapatite (HAp) powders have thermodynamically driven tendencies to lower their surface areas due to the formation of irreversible aggregates. To address this challenge, HAp hybrid powders are herein prepared by using a traditional wet-precipitation method with subsequent hydrothermal carbonization for surface modification. The crystallite size, crystallite degree and area ratio of the infrared peak assigned to bonding water against those of free water are determined to investigate the variation of HAp crystallization with processing parameters. The crystallization of HAp is facilitated by enriched water in a stealth layer with water molecules evolved by citrate, nitrogen (N)-containing methylene blue (MB), hydrogen-group-rich β-cyclodextrin (CD) and oxygen-containing organic carbon shells. The low surface areas result in fabrication of nano-sized HAp powders with a uniform size distribution, well-dispersed morphologies and smooth surfaces through calcination of [email protected] The pH values of acidic buffers increase slowly during incubation of [email protected] powders with chemical stability and a large grain size after calcination at 550°C for 2 h. The present study will shed light on the preparation of nano-sized inorganic powders with a uniform size distribution, well-dispersed morphologies and modulated chemical stability for potential applications as carriers of small molecular substances and fillers in composite materials.
Mohammad Salmani Mobarakeh, Ayoub Moghadam
Bioinspired, Biomimetic and Nanobiomaterials pp 1-9; https://doi.org/10.1680/jbibn.21.00035

Abstract:
Untreated dental caries is an important word challenge in human life. In this work, we synthesized polyvinyl alcohol-gum arabic-magnesium oxide nanoparticles new bionanocomposite and evaluated the antibacterial properties of its against Streptococcus mutans biofilm in vitro. For optimization of variables to have the maximum antibacterial property, L9 orthogonal array of Taguchi method was used for design of extraction conditions. The nanocomposites were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), X-ray energy diffraction (EDS), Thermogravimetric analysis (TGA) and transmission electron microscopy (TEM) tests. The FESEM images of nanocomposite inhibit that the nanoparticles are entirely surrounded with polymers chains of matrix and nanoparticles are deposited on the its walls, thus a layered nanocomposite is formed. The sheet width and size range of the nanocomposite was determined between 30-40 and 20-90 nm, respectively. The results showed that the synthesized nanocomposite with conditions of 1 mg/ml PVA, 3 mg/ml AG, and 6 mg/ml MgO (experiment 3), had the strongest antibacterial activity against the Streptococcus mutans bacteria’s biofilm. In this condition, the bacterial survival rate was the lowest at 0.21 CFU/ml and under this optimal conditions could inhibit the activity of Streptococcus mutans bacteria at a rate of 0.09 CFU/ml.
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