Ip Indian Journal of Clinical and Experimental Dermatology

Journal Information
ISSN / EISSN: 25814710 / 25814729
Total articles ≅ 343

Latest articles in this journal

Sunil Chaudhry, G Manmohan, Swathi Bhanavath
IP Indian Journal of Clinical and Experimental Dermatology, Volume 8, pp 223-233; https://doi.org/10.18231/j.ijced.2022.046

Abstract:
Vitiligo is also known as Safed Daagh, Safed Kodh, Phuleri and Savitra in vernacular. Vitiligo causes social and psychological distress, affecting 0.1 to 2 Percent global population. The pathology demonstrates depigmentation of the skin, with loss of melanocytes by autoreactive cytotoxic T cells. The vitiligo-infiltrating lymphocytes were T lymphocytes, and most were CD8+The elevated levels of H2O2 in the skin mediate the production of proinflammatory cytokines like IL-1β, IL6, and IL-8 indirectly by activating the calreticulin pathway. Autoimmunity in vitiligo is driven by the IFN-γ-CXCL10 cytokine (motif chemokine ligand) signaling pathway. No drug can stop the process of vitiligo. Most of the drugs are used in combination. Light therapy can help to restore some color. Topical steroids, calcineurin inhibitors, and narrow-band ultraviolet (UV)–B phototherapy are widely used. New depigmenting therapies are emerging such as helium-neon (He–Ne) lasers and prostaglandin E2 analogs. In cases of stable disease, surgical procedures such as skin grafting, blister grafting, orCellular suspension transplant are often tried. Ruxolitinib is the first medication that can restore pigment in patients with nonsegmental vitiligo. Tildrakizumab is also being evaluated in form of Topical Cream. Unfortunately, vitiligo is life long condition which is difficult to treat with satisfaction.
Somya Agrawal, Krishnendra Varma, Ujjwal Kumar
Ip Indian Journal of Clinical and Experimental Dermatology, Volume 8, pp 252-256; https://doi.org/10.18231/j.ijced.2022.051

Abstract:
Non-healing ulcers are a major cause of disability and impairment, interfering with physical and mental well-being of patients with Hansen’s disease. They are difficult to manage having longer duration of treatment and increased financial burden. Minimizing the duration of healing can be a major step in rehabilitation of such patients. Platelet rich fibrin (PRF) is a newer modality to hasten wound healing. It is a concentration of platelets suspended in plasma extracted after centrifuging patient’s own blood.: To study the efficacy of platelet-rich fibrin (PRF) in management of non-healing ulcers.: 13 patients with 16 non-healing ulcers of more than 8 weeks duration were included in our study but 2 patients were lost to follow up after first sitting. Written consent for the procedure and ethical clearance from Institutional Ethical Committee was taken. Detailed history was noted, baseline photographs and measurement of area and volume were done at every sitting at an interval of 1 week. An average of 2-3 sittings of PRF was done in each patient and then the ulcer was spontaneously allowed to heal with regular dressing till complete closure was achieved.: The mean age of cases in our study was 39.4 years. The average percentage improvement in area and volume was 97.12% and 98.72% respectively. Out of 14 ulcers, 12 (85.71%) ulcers showed complete healing within 4 weeks. The mean duration of healing was found to be 2.41 weeks. The procedure was safe with no noted adverse events. The limitation of our study was small sample size. More studies are needed with larger sample size to confirm the results.: PRF is an inexpensive, safe, feasible and effective procedure in the management of non-healing ulcers.
Mohammed Tariq Iqbal, Anirudha Gulanikar
IP Indian Journal of Clinical and Experimental Dermatology, Volume 8, pp 239-242; https://doi.org/10.18231/j.ijced.2022.048

Abstract:
Acne being a common dermatologic disease of adolescents with its varied clinical presentation and recurrence, with relevance of up to 95% in all the population has been difficult to treat. It has been recognised as one of the conditions in Global Burden of Disease (GBD). To study adult acne with clinical history and hormonal evaluation. Patients over the age of 25 years presenting with acne in a tertiary care hospital were included in the study. A detailed history and examination was done, with factors such as alopecia, hirsuitism and menstrual irregularity.Hormonal Investigations and Ultrasound of abdomen and pelvis were done for all patients. Out of 30 patients included in the study 30 were women. The mean age of the patients was 32.52 years. Persistent acne was observed in 50%, while it was late onset in 50% with duration from 1 month to 25 years. Most common grades included grade II with 53%, grade III with 23.33 %, and grade I with 20%. Hirsuitism in 33.33% and alopecia in 6% was also seen. On further investigations it was found that Serum DHEA-S and Serum Testosterone were within normal limits, Prolactin increased in 13.33%, LH reduced in 6.66%, FSH increased in 6.66% and decreased in 3.33%, Fasting Insulin increased in 3.33%, Postprandial Insulin increased in 6.66%. Thyroid profile showed TSH decreased in 3.33%, T3 increased in 13.33% and T4 increased in 13.33%. Ultrasound findings of 26.66% patients were positive for PCOD. Adult acne is predominant in females as compared to adolescent acne, with grade II acne being more predominant, the role of hormones in adult acne has yet to show its co-relation with the disease. Studies looking into end organ sensitivity would further help in understanding role of hormones in adult acne.
Ann John Kurien, Joydeep Roy, Kinnor Das
IP Indian Journal of Clinical and Experimental Dermatology, Volume 8, pp 217-222; https://doi.org/10.18231/j.ijced.2022.045

Abstract:
The most frequent calamity in the world, flooding has killed around 53,000 people in just the previous ten years. Prior to 2011, flooding was the most frequent type of disaster on the planet, accounting for about half of all natural disaster victims and nearly US $185 trillion in economic losses. Flood dermatoses can be divided into four categories: (i) Inflammatory skin diseases (such as irritant contact dermatitis); (ii) Fungal and bacterial infections; (iii) Traumatic skin diseases; and (iv) Other miscellaneous skin diseases (such as an allergic reaction to an insect bite and psycho-emotionally aggravating primary skin diseases). Here we review and summarise a number of articles on flood related skin diseases in an effort to improve knowledge and recognition of these conditions for both dermatologists and general practitioners in order to provide the best and most appropriate management of these particular skin diseases in emergency situations.
Noreen Munshi, Krishnendra Varma
IP Indian Journal of Clinical and Experimental Dermatology, Volume 8, pp 248-251; https://doi.org/10.18231/j.ijced.2022.050

Abstract:
The majority of treatments for skin warts include destructive techniques like electrocautery and cryotherapy. These techniques of treatment frequently result in recurrence and scarring. Examining the safety and efficiency of intralesional vitamin D3 injection in cutaneous warts is the goal of this study.Total 50 people with recalcitrant warts of different dimensions, frequencies, and longevity participated in the study. 0.2 to 0.5 ml of vitamin D3 (600,000 IU, 15 mg/ml) were injected into the bases of warts. A maximum of 5 warts were administered per session, with sessions occurring every 2 weeks till the warts vanished, or for a total of 3 sessions. Following the final injection, individuals were monitored for six months to look for any recurrence.The trial was completed by 50 patients. Out of 50 patients, 35 (or 70%) showed a complete reaction, five (10%) showed a partial response, and ten (10%) showed no response. In every case, the distant warts completely disappeared.A safe, effective, and affordable therapy option for resistant warts is intralesional vitamin D3.
Sudhir Singh
IP Indian Journal of Clinical and Experimental Dermatology, Volume 8, pp 269-270; https://doi.org/10.18231/j.ijced.2022.056

Abstract:
Done a lot of cases successfully in our place with bacteriophages in small nonhealing chronic wounds but its use in extensive infected burn wound healing is also encouraging. Our clinical evidence of topical application of bacteriophages on extensive multi-drug resistant [MDR] bacterial infected burn wounds has been done for the first time and has never been reported in the literature. The medical revolution is on the horizon for treating superbugs and their positive effect on the economy especially in treating skin wounds.
Noreen Munshi, Krishnendra Varma
IP Indian Journal of Clinical and Experimental Dermatology, Volume 8, pp 263-265; https://doi.org/10.18231/j.ijced.2022.054

Abstract:
"The wolf isotopic phenomenon corresponds to the appearance of a skin disease in a place on the body that was previously affected by another, already healed dermatosis." A 35-year-old woman presented with a transversely distributed zosteriform eruption about 12 to 14 cm in length, consisting of erythematous, scaly, moderately pruritic papules on the left flank that spread to the back (does not cross the midline) for several weeks after locally healed herpes zoster (HZ) lesions. No other skin or mucosal sites were included. Routine examination of blood, urine and stool showed no abnormality. A biopsy sample was taken from one of the lesions. Histopathological examination showed typical lichen planus changes, confirming the diagnosis of post-Herpes zoster zosteriform lichen planus (ZLP). The lesions resolved after treatment with topical steroids. Zosteriform lichen planus (ZLP) is an example of a Wolf isotopic phenomenon appearing after HZ at the same site. The exact pathogenesis of ZLP is unknown, it is assumed that persistent viral proteins could be responsible for the hypersensitivity reaction.
Kalle Gauthami Sree, N Aishwarya, P Vijaya Lakshmi
IP Indian Journal of Clinical and Experimental Dermatology, Volume 8, pp 257-259; https://doi.org/10.18231/j.ijced.2022.052

Abstract:
The AEC syndrome or Hay wells syndrome is an unusual autosomal dominant disorder characterised by Ankyloblepharon, Ectodermal dysplasia and Cleft palate and/or Cleft lip. This syndrome occurs as a result of missense mutation in TP63 affecting P63 SAM of the gene, which is a protein-protein interaction domain. It is associated with some irregularities like Cleft palate /Cleft lip, severe scalp erosions and abnormalities of epidermal appendages including hypotrichosis, hypodontia, absent or dystrophic nails & mild hypohydrosis. We, here by report a case of full term baby born to third degree consanguineous parents with features of cleft lip and cleft palate, multiple erosions present over back, alopecia over left side of scalp along with few erosions over right side of scalp, sparse eye brows & eye lashes, Ankyloblepharon, Microphallus, Dystrophic finger and toe nails due to its rarity. Diagnosis is made commonly by clinical examination and Genetic analysis.
Sourab D, Mahajabeen S Madarkar
IP Indian Journal of Clinical and Experimental Dermatology, Volume 8, pp 243-247; https://doi.org/10.18231/j.ijced.2022.049

Abstract:
Pityriasis versicolor (PV) is a superficial mycoses caused by a lipophilic fungus; Malassezia yeast. Dermoscopy can be used as a complementary tool for assessing PV, but histopathology is confirmatory, whenever results of KOH (potassium hydroxide) examination are inconclusive. There is dearth of Indian data on the findings of dermoscopy and histopathology of PV. To find the correlation between dermoscopic and histopathological features in Pityriasis versicolor. Fifty consecutive patients diagnosed with PV were recruited in the cross sectional study. KOH mount of the skin scrapings from the lesions was done on the patients and were positive in all the patients. Dermoscopy was done in all the patients using ILLUCO Dermoscope and features were noted. Biopsy was sent for histopathological examination. Hypopigmented variant was the most common type (62%) in the patients. Dermoscopic analysis showed altered pigmentary network as the most common finding in almost all the patients, followed by scaling which was present in 21 patients. Folliculocentric pattern was seen in 20% of the patients. A peculiar finding contrast halo ring around the primary altered pigmentation was observed in 4 patients. Invasion of hair follicle by yeast was noticed in 18% patients. The most common histopathological change seen was perivascular infiltrate (78%) followed by hyperkeratosis (62%). There was presence of hyphae spores in 40% of the patients. 42% of the patients had spongiosis in their histopathological pattern. Special stain was done in 20 patients. Dermoscopy with features such as altered pigmentary network, contrast halo sign and yeast invasion of hair follicles when complemented with the histopathological features like perivascular infiltrate, hyperkeratosis, hyphae spores and spongiosis help in diagnosing PV.
Amar Shirsat, Bela Shah, Abhijit Trailokya
IP Indian Journal of Clinical and Experimental Dermatology, Volume 8, pp 211-216; https://doi.org/10.18231/j.ijced.2022.044

Abstract:
The burden of dermatological conditions is huge on the global health accounting for 44.1 million DALYs worldwide. Impetigo is a highly contagious bacterial infection with 2.5 time’s greater likelihood in pediatrics (12.3%) than in adults (4.9%). Micro-organisms causing impetigo include bacteria like or both. The management of Impetigo is with topical and systemic antimicrobial agents. Topical antimicrobial resistance is on the rise in patients with Impetigo. Therefore, there is clearly a need for newer antimicrobials having different mode of action and showing good activity against non-responding strains in the management of impetigo. Ozenoxacin is a novel, topical quinolone with a good safety and tolerability profile in the management of Impetigo. The authorizing bodies namely USFDA, European Medical Agency, and DCGI have approved the use of Ozenoxacin 1% cream for the topical treatment of impetigo due to in adult and pediatric patients 2 months of age and older.
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