Journal of Cancer Research and Therapeutics

Journal Information
ISSN / EISSN: 09731482 / 19984138
Published by: Medknow
Total articles ≅ 4,080

Latest articles in this journal

Avnica Agarwal, Mayank Das, Pannalal Jaiswal, Panchali Kashyap
Published: 1 January 2022
Journal of Cancer Research and Therapeutics; https://doi.org/10.4103/jcrt.jcrt_290_22

Abstract:
Tobacco is one of the leading causes of various types of cancer, and more than five million people die globally from its ill-effects every year. It is reported that by the year 2040, tobacco-related deaths will exceed ten million annually. Smoking cessation programs are considered very useful in helping tobacco users to quit, but it is a very difficult addiction to break; thus effective approaches are required. The authors present a case of an 84-year-old male patient who was a chronic smoker and used to smoke 35–40 bidis per day. He started to notice the physical addiction and withdrawal symptoms due to which he was not able to quit tobacco on his own. After expert counselling, his habit of smoking gradually decreased and after a few months, he was able to quit tobacco completely with the help of behavioral modification and pharmacotherapy.
Arpita Rai, PriyanshuKumar Shrivastava, Ansul Kumar, Yogendra Aggarwal, Amit Kumar, Anushka Agrawal
Published: 1 January 2022
Journal of Cancer Research and Therapeutics; https://doi.org/10.4103/jcrt.jcrt_2275_21

Abstract:
Oral malignant and potentially malignant conditions affect several people worldwide each year. The early diagnoses of these conditions play an important role in prevention and recovery. Vibrational spectroscopy techniques such as Raman spectroscopy (RS) and Fourier-transform infrared (FTIR) spectroscopy are used in the early, non-invasive, label-free diagnosis of malignant and pre-malignant conditions, and are areas of active research. However, there is no conclusive evidence suggesting the translatability of these methods into clinical practice. This systematic review and meta-analysis presents pooled evidence for RS and FTIR methods in the detection of malignant and potentially malignant conditions of the oral cavity. Electronic databases were searched for published literature on RS and FTIR in the diagnosis of oral malignant and potentially malignant conditions. The pooled sensitivity, specificity, diagnostic accuracy, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), pre-test, and post-test probability were then calculated using the random-effects model. A subgroup analysis was conducted separately for RS and FTIR methods. A total of 12 studies were included (8 of RS; 4 of FTIR) as per the eligibility criteria. The pooled sensitivity and specificity of the vibrational spectroscopy methods were calculated to be 0.99 (95% confidence interval [CI]: 0.90, 1.00) and 0.94 (95% CI: 0.85, 0.98), respectively. The area under the curve (AUC) for the summary receiving operator characteristic curve was found to be 0.99 (0.98–1.00). Therefore, the results obtained in this study suggest that the RS and FTIR methods offer great potential to be used in the early diagnosis of oral malignant and pre-malignant conditions.
JayantS Goda, Prashant Nayak, Shwetabh Sinha, Arpita Sahu, Kishore Joshi, OindrillaRoy Choudhary, Ritesh Mhatre, Naveen Mummudi, JaiPrakash Agarwal
Published: 1 January 2022
Journal of Cancer Research and Therapeutics; https://doi.org/10.4103/jcrt.jcrt_2317_21

Alireza Farsinejad, Reza Vahidi, MaryamSamareh Salavatipour, Seyedehmehrnaz Kouhbananinejad, Mahla Lashkari, MahlaSattarzadeh Bardsiri, Masoud Moghadari, Bahareh Kashani
Published: 1 January 2022
Journal of cancer research and therapeutics; https://doi.org/10.4103/jcrt.jcrt_1084_21

Lawrence D'Cruze, B Archana, Sandhya Sundaram, Krishnakumar Ramanathan, Krishnamurthy Ganesh
Published: 1 January 2022
Journal of cancer research and therapeutics; https://doi.org/10.4103/jcrt.jcrt_257_22

Abstract:
J Indian Prosthodont Soc, Official publication of Indian Prosthodontic Society
Mihir Gangakhedkar, Akhlesh Rajpoot, Monika Singh, Mayank Mishra
Published: 1 January 2022
Journal of cancer research and therapeutics; https://doi.org/10.4103/jcrt.jcrt_1612_21

Abstract:
Undifferentiated Pleomorphic Sarcoma (UPS) is a common soft tissue sarcoma that can develop in various organs, but lung involvement is usually due to metastasis. UPS originating primarily in the lungs is called primary pulmonary undifferentiated pleomorphic Sarcoma (PPUPS) and is exceptionally rare. It is a high-grade pleomorphic neoplasm with no identifiable lines of differentiation. Thus, it is essentially a diagnosis of exclusion that requires extensive clinical, radiographic and histopathological evaluation. Herein we report the case of a 49-year-old gentleman who presented with anemia and weight loss and was found to have a large right lung mass. The lesion was diagnosed as PPUPS after detailed histopathological, immunohistochemical and molecular analysis and exclusion of a possible extrapulmonary origin.
Abhijit Mandal, Ganeshkumar Patel, Avinav Bharati, Sunil Choudhary, Ritusha Mishra, Ankur Mourya
Published: 1 January 2022
Journal of cancer research and therapeutics, Volume 18; https://doi.org/10.4103/jcrt.jcrt_330_20

Abstract:
Purpose: Development and validation of a simple and convenient computational program in MATLAB environment for estimating the tumor control probability (TCP) and the normal tissue complication probability (NTCP), as a decision support system for routine plan evaluation. Materials and Methods: We developed an in-house software using MATLAB 2016b (Mathworks) for estimating TCP and NTCP named as RBMODELV1. The program contains Niemierko free equivalent uniform dose (EUD) program code provided in authors research article. For rest of radiobiological (RB) models in the software separate coding is performed. The program accepts cumulative dose–volume histogram file in (.txt) format containing two columns dose and volume. A set of two RB parameters were prepared, default and user-dependent in excel sheet named as RBDATA. We cross-validated results of RBMODELV1 software with BioSuite software for Poisson's TCP model and Lyman-Kutcher-Burman (LKB) model. A set of total 20 patient's data of head and neck site took under study and respective TCP and NTCP calculated by all the RB models and compared. Results: This is the first study in which we tried to establish correlation between the mean doses (EUD) received by parallel structure (parotid gland and oral cavity) and predicted percentage of NTCP values. It is found that mean dose in the range of 35–40 Gy for parotid gland can result in more than 50% NTCP predicted by all four RB models. Similarly oral cavity receiving mean dose in the range of 53–58 Gy can results in more than 35% NTCP predicted by all the four models. There is <3% variation observed between TCP calculated by BioSuite and RBMODELV1 software and <4% variation observed between predicted NTCP for parotid gland and oral cavity OAR from LKB model by both the software. Conclusion: We created simple software RBMODELV1 which can be used as a research tool as well as decision support system.
Thara Tunthanathip
Published: 1 January 2022
Journal of cancer research and therapeutics, Volume 18; https://doi.org/10.4103/jcrt.jcrt_1469_20

Abstract:
Background: Malignant transformation (MT) of low-grade astrocytoma (LGA) produces a poor prognosis in benign tumors. Currently, variables linked with MT of LGA have proven equivocal. The present study aims to evaluate the risk variables, indicating that LGA gradually differentiates to malignant astrocytoma. Methods: Retrospective cohort analysis of LGA patients was performed. Both univariate and multivariate studies were used to discover variables connected to MT using the Cox regression method. As a result, the cumulative incidence of MT for each covariate survival curve was built after the final model. Results: In the current study, 115 individuals with LGA were included in the analysis, and MT was found in 16.5% of cases. In the case of MT, 68.4% of patients progressed to glioblastoma, whereas 31.6% progressed to anaplastic astrocytoma. Significant factors included supratentorial tumor (hazard ratio (HR) 3.41, 95% CI 1.18–12.10), midline shift > 5 mm (HR 7.15, 95% CI 2.28–34.33), and non-total resection as follows: subtotal resection (HR 5.09, 95% CI 0.07–24.02), partial resection (HR 1.61, 95% CI 1.09–24.11), and biopsy (HR 2.80, 95% CI 1.18–32.52). Conclusion: In individuals with LGA, MT dramatically altered the disease's natural history to a poor prognosis. The present study's analysis of the clinical features of patients indicated supratentorial LGA, a midline shift greater than 5 mm, and the degree of resection as risk factors for MT. The more extensive the resection, the greater the reduction in tumor load and MT. In addition, more molecular study is necessary to elucidate the pathophysiology of MT.
Hatice Karaman, Fatma Senel, Arzu Tasdemir, Ipek Özer, Merve Dogan
Published: 1 January 2022
Journal of cancer research and therapeutics, Volume 18; https://doi.org/10.4103/jcrt.jcrt_601_20

Abstract:
Background: Breast carcinoma diagnosis can be made with core-needle biopsy (CNB), but there are controversies regarding the evaluation of hormone receptor (HR) status in needle biopsy specimens. When preoperative neoadjuvant therapy is required in breast cancer cases, the CNB specimen should be evaluated to decide on the treatment. Objectives: In this study, we aimed to compare the estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and silver in situ hybridization (SISH) results of the CNB specimens and surgical specimens (SS) of our breast carcinoma cases. Materials and Methods: This retrospective study included cases diagnosed with breast cancer in our center for approximately 1 year between 2017 and 2018. About 97 cases with both CNB specimens and SS were included in the study. Data such as the ER, PR, HER2, and SISH evaluation results in CNB and SS, age distribution and histopathological type, metastatic lymph nodes, lymphovascular invasion, tumor size, and grade of the tumor were recorded. The data were analyzed using SPSS 22.0 (Statistical Package for the Social Sciences, Armonk, NY, USA) software. Results: All of the cases were female and 70.1% of them were aged over 45. About 27.8% of the cases were aged 31–45 years, and 2.1% were aged under 30. When evaluated according to the histopathological type of the tumor, 71.1% of cases were invasive ductal carcinoma (IDC), 8.2% were invasive lobular carcinoma (ILC), 6.2% were IDC + ILC, 11.3% were another carcinoma, and 3.1% were in situ carcinoma. 12.4% of the cases were Grade I, 43.3% were Grade II, and 20.6% were Grade III. 43.3% of our cases' tumor size were ≤2 cm and 56.7% >2 cm. 50 (51.5%) of these cases had no lymph node metastasis. It was found out that 36 (37.1%) of the cases had 1–4 metastatic lymph nodes and 11 (11.3%) of them had 5 and more metastatic lymph nodes. It was found out that 44 (45.4.%) of the cases had no lymphovascular invasion and 53 (54.6%) of them had a lymphovascular invasion. When HR statuses in CNB and SS were compared, ER was found to have a sensitivity of 96.1% and a specificity of 100%. PR was found to have a sensitivity of 94.2% and a specificity of 66.7%. HER2 was found to have a sensitivity of 100% and a specificity of 73.4%. Conclusion: ER evaluation results are reliable in deciding on needle biopsy material. PR may show the heterogeneous distribution in HER2 tumor. Thus, if PR and HER2 results in needle biopsy material are negative, assessments should be repeated in SS.
Jomon Raphael Chalissery, Febin Antony, K Mathew Varghese, G Paul Gopu, Minu Boban
Published: 1 January 2022
Journal of cancer research and therapeutics, Volume 18; https://doi.org/10.4103/jcrt.jcrt_924_21

Abstract:
Introduction: Concurrent chemoradiation therapy (CCRT) is the standard of care in the management of cervical cancer (International Federation of Gynecology and Obstetrics [FIGO] 2008 Stages IB2-IVA). Apart from the myelotoxic effects of chemotherapy, irradiation of pelvic bone marrow (BM) in the radiation field, can also contribute to hematological toxicity. Objectives: We examined the relationship of irradiated BM volume and neutropenia in cervical cancer patients undergoing CCRT. Materials and Methods: This prospective study was conducted in a tertiary cancer center with a longitudinal study design. A total of 43 patients undergoing CCRT for cervical cancer were included. Using auto bone segmentation, the external contour of pelvic bones from L4 vertebral body to ischial tuberosities were delineated as BM. The volume of BM receiving 10, 20, 40, 50 Gy was calculated. Complete blood counts were done weekly to evaluate the neutropenia and were graded according to Common Terminology Criteria for Adverse Events, version 3.0. The risk of developing neutropenia was analyzed using logistic regression. Results: Twenty-seven patients (62.8%) received 5 cycles of chemotherapy, 14 patients (32.6%) received 4 cycles of chemotherapy and 2 patients (4.7%) received 3 cycles of chemotherapy. Overall, 22 patients (51.2%) experienced acute neutropenia. On multivariate analysis increased BM V50Gy had a statistically significantly odds of developing any grade of neutropenia (odds ratio [OR] =1.43; 95% confidence interval [CI], 1.03–1.97; P = 0.028). When comparing patients receiving BM V40Gy ≥40% with BM V40Gy <40% odds of any grade of neutropenia was increased (OR = 2.03; 95% CI, 0.55–7.42; P = 0.28). Moreover, when comparing patients receiving BM V50Gy ≥15% with BM V50Gy <15% odds of any grade of neutropenia was increased (OR = 2.13; 95% CI, 0.57–7.97; P = 0.26). Conclusions: High-dose irradiation to the larger volume of BM prevents compensatory hyperplasia which leads to neutropenia in patients undergoing CCRT for cervical cancer.
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