Surgery to remove impacted lower third molars involves risk for exposing the inferior alveolar neurovascular (IAN) bundle. The platelet rich fibrin (PRF) should be adequate to facilitate healing in self-contained defects and has been widely used in the oral and maxillofacial surgery. Therefore, we used PRF to treat patients whose IAN bundle was exposed during surgery. With a 98% chance of recovery at one-year post-surgery after treatment with PRF, seeing an exposed IAN bundle during impacted lower third molar removal surgery also suggests its close association with the third molar and poses a 20% risk of paresthesia. The use of PRF is such patients could support healing that can lead to promising result.

The acellular dermal matrices (ADMs) are an alternative to autologous soft tissue transplants. They represent a scaffold for ingrowing blood vessels and cells, leading to a fast revascularization and tissue integration. However, the opinions regarding their performance and results can be easily divided. While some claim unsatisfactory results, there is an extensive literature support that confirms the opposite. Therefore, this short review summarizes several opinions and concludes that ADMs are suitable alternatives that can support predictable results.

The immediate single-tooth implant placement in the aesthetic zone represents a clinical challenge for preserving the bone contour. Aim of this clinical case was to observe the effect of grafting the buccal bone gap during immediate implant placement. The buccal bone gap was filled with a new hydroxyapatite-sugar cross linked collagen matrix to preserve the mucosal contour. At re-entry surgery, partial preservation of the buccal bone wall was observed after 6 months of healing and stable peri-implant bone was present. Such treatment during immediate single-tooth implant placement in the aesthetic zone may provide buccal contour stability.

Non resorbable polytetrafluoroethylene membranes find great use in everyday oral surgery treatments. We aimed to verify the performance of high-density polytetrafluoroethylene (hdPTFE) membrane in open healing after alveolar ridge augmentation at two patients. For that reason, we raised full thickness flap and grafted with different xenograft granules that were covered with resorbable collagen membrane. Then the grafted area was covered with high-density polytetrafluoroethylene membrane (permamem®) and stabilized with sutures by leaving it partially exposed. Six weeks after open healing, the permamem® was removed and successful post-operative healing with no complications were observed. The newly formed soft tissue grew under the membrane and completely covered the new alveolar ridge volume. There were no signs of dehiscence or infection, and the patients had no pain or discomfort, neither after suture nor the membrane removal. Also, there were no visible signs of bacterial plaque on the membrane after its placement and during removal. After eight months implants were successfully installed, and full mouth prosthetic reconstruction was following the osseointegration. In conclusion, the high-density polytetrafluoroethylene membrane efficiently supported open healing and led to successful alveolar ridge augmentation.

Background and objectives: The collagen matrices are widely used for regeneration procedures alone or in combination with other dental regeneration materials. The aim of this work was to evaluate the soft tissue healing with acellular dermal collagen matrix (ADCM) being used in various defects. Materials and Methods: The ADCM - mucoderm® was used in peri-implant soft tissue augmentation, hard and soft tissue management in immediate restoration and sealing of extraction socket. For that reason, five patients were retrospectively analysed. Results: The collagen matrix underwent active remodelling into new soft tissue and successful soft tissue healing was observed. Conclusion: The use of mucoderm® led to successful soft tissue treatment in various defects.

Bone volume loss appears after tooth extraction and socket preservation is the most applied procedure to prevent an alveolar resorption. The aim of this study was to retrospectively analyse three socket preservation cases with high-density polytetrafluoroethylene barrier membrane (permamem®) for open healing with and without the use of additional dental regeneration biomaterials. Here no bacterial plaque was present and the soft tissue completely re-epithelialized, which allowed new bone formation and implant treatment. The current findings indicate that the use of this membrane, leads to successful socket treatment during open healing.

Bovine bone substitutes are among the most commonly used biomaterials for sinus grafting application. The aim of this work was to verify the clinical use and performance of a novel natural bovine bone substitute with hyaluronate in a sinus lifting procedure. Therefore, a lateral sinus lift approach was used, and a very strong hard tissue formation of residual xenograft granules embedded into newly formed bone was observed after eight months, as two implants were finally installed. In conclusion, the bovine bone substitute with hyaluronate supported efficient defect grafting and achieved successful sinus augmentation.

The collagen fleece is widely used biomaterial for healing in dental regeneration procedures. The aim of this work was to evaluate the regenerative potential of collagen sponge (collafleece®) in combination with other biomaterials being used in immediate implantation and sinus lift. For that reason, four patients were retrospectively analysed. The collagen fleece successfully supported the wound healing, controlled the bleeding, and assisted the healing of the Schneiderian membrane. The use of collafleece® led to successful treatment in combination with other biomaterials when used in immediate implantation and sinus lift.