Objective: This study sought to examine whether the inclusion of self-efficacy theory could increase the effectiveness of awake prone positioning in COVID-19 patients. Method: A total of 80 COVID-19 patients admitted to the respiratory department of our hospital between December 2022 and February 2023 were randomly allocated into either the intervention group (n=40) or the control group (n=40). The control group received routine respiratory medicine treatment and underwent awake prone positioning, whereas the intervention group received additional self-efficacy theory intervention alongside awake prone positioning. The patients’ oxygen saturation level (SpO2) and respiratory rate (RR) were closely monitored at three different time points: before awake prone positioning, 30 minutes and 1 hour after awake prone positioning. Furthermore, the patients’ Modified Medical Research Council (mMRC) dyspnea scale and self-efficacy scores were evaluated on the first, second, and third days of awake prone positioning. The cumulative duration of awake prone positioning and patient satisfaction were recorded on the third day of the intervention. Results: The data indicate that the intervention group demonstrated significant improvements in both SpO2 and RR compared to the control group, both at 1 hour and at the end of awake prone positioning (P＜0.05). Moreover, the intervention group experienced a substantial reduction in the dyspnea index compared to the control group on the second and third day (P＜0.05). The intervention group also reported higher self-efficacy scores, cumulative duration of awake prone positioning ventilation on the third day, and satisfaction levels compared to the control group on the first, second, and third day (P<0.05). Conclusions: The incorporation of self-efficacy theory to awake prone positioning improves the short-term outcomes of COVID-19 patients. This patient-centered approach has the potential to increase patients’ self-efficacy and satisfaction levels, emphasizing the importance of incorporating patient-centered care in healthcare practices.

Objective: This study aimed to evaluate the effectiveness of a modified patient experience-based bowel preparation protocol for capsule endoscopy combined with colonoscopy. Methods: A total of 262 patients who underwent capsule endoscopy combined with colonoscopy in a tertiary hospital in Zhuhai city from July to December 2021 were enrolled in this study. They were divided into the control group (n=141) and the experimental group (n=121) using the random number method. The experimental group used the modified bowel preparation protocol while the control group used the conventional preparation protocol. Post-examination indicators, including sleep quality, gastrointestinal discomfort, nausea, vomiting, abdominal pain, and satisfaction, were compared between the two groups. Results: The data showed that the experimental group’s preparation medication had a better taste and was effective in improving patient symptoms, such as gastrointestinal discomfort, nausea and vomiting, abdominal pain, and sleep quality, compared to the control group. Moreover, both patients and nurses reported greater satisfaction with the experimental group’s bowel preparation time compared to the control group, with statistically significant differences observed (P < 0.05). Conclusions: The modified bowel preparation protocol could improve patient sleep quality, reduce adverse reactions, and increase patient comfort and satisfaction.

Objective: The zinc finger E-box binding homeobox (ZEB2), which can accelerate the nuclear DNA replication by inducing the activation of upstream transcription promoters, was widely considered as an oncogene. Recent study has found that the overexpression of ZEB2 is associated with a better prognosis in hepatocellular carcinoma. However, its roles in tumor growth, metastasis, and immunology are yet to be elucidated in COAD. Methods: The pan-cancer sequencing data was acquired from The Cancer Genome Atlas (TCGA)-Pan cancer cohort, normal human tissue data was acquired from the Genotype-tissue expression (GTEx) database, and Broad Institute Cancer Cell Line Encyclopedia (CCLE) were downloaded from UCSC Xena. We used the cBioPortal webtool to analyze and visualize the ZEB2 pan-cancer genomic alteration rate. GEO Expression Datasets were used to explore ZEB2 expression levels in COAD patients. UCSC Xena database was used to download prognostic information of COAD patients. The Cox regression and Kaplan–Meier analyses were used to assess the prognostic role of ZEB2 in COAD. Kyoto Encyclopedia of Genes and Genomes (KEGG) was performed to determine the biological pathways. Gene Ontology (GO) enrichment analysis was performed to determine the biological processes, molecular functions, and cellular components that were altered in a ZEB2-dependent manner in COAD. The module analysis of PPI interaction network was performed using the MCODE tool of Cytoscape software, and the characteristic molecules were selected by cytohHubba tool. CIBERSORTx database was used to analyze the ZEB2 expression in the presence of 22 types of immune infiltrating cells. Results: This study found that ZEB2 was aberrantly expressed in most cancer types, and it was significantly downregulated in COAD compared with normal tissue. In addition, our findings also show that overexpression of ZEB2 was associated with a better prognosis in COAD. Mechanistic analysis revealed that overexpression of ZEB2 was associated with the neutrophil extracellular trap formation in COAD. And the results show that ZEB2 expression was significantly correlated with several kinds of immune cell infiltration. Conclusion: This study demonstrates that overexpression of ZEB2 was associated with better prognoses in patients with COAD. ZEB2 has close relationship with ACTB, which was highly related to NETs. These findings suggest a dual role of ZEB2 in COAD growth, metastasis, and immunology.

Since the emergence of the novel coronavirus epidemic, online teaching has begun to be widely carried out in various universities, and has been widely recognized by teachers and students. This article discusses the online teaching method of histology and embryology in Zhongshan Medical College of Sun Yat-sen University, analyzes the advantages and disadvantages of online teaching, and proposes improvement measures for online teaching in order to provide reference for better online teaching in universities.

Objective: To evaluate the effects of lactulose for bowel preparation prior to colonoscopy in adults. Methods: By searching for literature pertaining to RCT (randomized controlled trial) of bowel preparation with lactulose in adults up to 10th of July, 2021. The experimental group utilizes lactulose oral solution as the solution of choice for bowel preparation while the control group uses the standard bowel preparation solution. Literature selection and data extraction were completed independently by 2 researchers, including literature quality control. Data analysis was completed using the software RevMan5.2. Results: 11 RCT was included for data analysis. Meta-analysis showed that the lactulose group had a lower incidence of adverse effects [OR=13.58, 95CI% (6.10, 30.24), p<0.0001] and better tolerability [OR=13.58, 95CI% (6.10,30.24), p<0.0001] when compared with the control group. However, the bowel cleanliness was statistically insignificant between the two groups [WMD=0.26，95%CI (-0.31，0.82), p=0.38]. Conclusion: according to current evidences, as a solution for bower preparation, lactulose has a lower incidence of adverse effects such as emesis or diarrhea, while effectively increasing tolerability, however it is not a superior solution for bowel preparation in terms of bowel cleanliness when compared with other standard choices. More high quality researches will be required to support its use.

This article aims to explore the effect of the intangible cultural heritage co-creation model on the psychological healing of special children. Through the review and analysis of relevant literature, this paper believes that the intangible cultural heritage co-creation model has positive effects on the psychological healing of special children, and can help them relieve anxiety, enhance self-confidence, and improve social skills, etc. At the same time, this paper also analyzes the problems existing in the implementation of the intangible cultural heritage co-creation model, and proposes corresponding solutions.

To summarize the nursing experience of 55 cases of Trimeresurus stejnegeri snakebites. A review of 55 cases of snake bites received by our hospital as a designated snake bite hospital, Give emergency treatment and wound care. Nursing critical points included: Partial wound closure treatment, Observation and management of wounds and injured limbs, the anti-venom medicine should be used as early as possible, mental health care, and health promotion; after a series of nursing care, the patients were all cured and released from the hospital.

Objective: This study aimed to investigate the value of lactate/albumin ratio in prediction of mortality in intensive care unit (ICU) patients with post-operative intestinal obstruction. Method: A retrospective analysis was conducted with patient data from the eICU Collaborative Research Database (eICU-CRD). According to the outcome, the patients with post-operative intestinal obstruction who were admitted to ICU within 24 hours after surgery were separated into two groups: survivors (233 cases) and non-survivors (35 cases). Their clinical characteristics and scoring data were collected. Logistic regression analysis was used to evaluate the risk factors for death, and these risk factors were further included for the construction of the receiver operating characteristic curve (ROC) to evaluate the predictive value of death for these patients. Results: In-hospital mortality for patients admitted to ICU with post-operative intestinal obstruction was 13.1% (35/268). The level of lactate/albumin ratio was significantly higher in non-survivors than in survivors (1.36±1.54 versus 0.70±0.64; P<0.001). Logistic regression analysis showed that the lactate/albumin ratio (OR=0.667, 95%CI: 1.328-2.485, P=0.001) could predict in-hospital mortality independently for the patients in ICU with post-operative intestinal obstruction. Further analysis showed that the area under the ROC curve (AUC) value of lactate/albumin ratio level was 0.681. Conclusions: These data suggested that the lactate/albumin ratio has potential predictive value for mortality in ICU patients with post-operative intestinal obstruction.

Review the nursing plan of 6 patients with hemophilia arthritis treated by Chinese medicine fasting therapy in Traditional Chinese Medicine Department from 2019 to 2021, the author summarize the nursing experiences of nursing plan, health education, coagulation factor infusion nursing, rehabilitation functional exercise nursing during the treatment , in order to improve the nursing and treatment effect of hemophilia arthritis patients by the treatment of Chinese medicine fasting therapy, and we can promote the recovery of patients and enhance the quality of life.

Under the teaching goal of "Golden Course" proposed by the Ministry of Education, student-centered online and offline blended teaching has become a new hot topic. Combining online and offline teaching and applying it to the teaching practice of histology and embryology, this study takes the offline course as the main line supplemented by online pre-review and review, group discussion, flipped classroom and other forms of learning.. This paper takes class 3 students of 2018 and 2019 eight-year clinical medicine as the research subjects, evaluates the teaching effect through the data analysis of experimental results, final evaluation results and teaching feedback survey, and applies SPSS20.0 software to statistically analyze the students' grades. The results have shown that the students' experimental scores and final evaluation scores in the online and offline hybrid teaching group are better than those in the traditional offline teaching group, although the differences are not significant (P> 0.05), and the student participation is also higher. It shows that the online and offline blended teaching mode is better than the traditional teaching mode, which can improve the teaching quality of histology and embryology, promote the interaction between teachers and students, and improve teaching and learning.