Background: In this study, it was aimed to test the anti-tumoral effects of melatonin in vivo. In the literature review, no study was found that examined the anti-tumoral effect of melatonin at night on an experimental tumor model in vivo. Therefore, in the study, the anti-tumoral effect of melatonin was tested in solid tumor tissue formed in Swiss albino male mice. Methods: Swiss albino male mice formed Swiss albino male mice in vivo and 80 Swiss albino male mice weighing 25-30 g and aged 10-12 weeks were used. The subjects were divided into 10 groups in total (n=8). These groups are divided into two main groups as light and dark. All animals except the control group were injected intramuscularly (i.m.) with EAT to create EST in the right leg scapula of the subjects. Different doses of melatonin were injected intraperitoneally (i.p.) daily to the experimental groups. EST was created by inoculating EAT 2 days after administration of melatonin. Melatonin application was made between 18:00 and 20:00 in the evening. In addition, light groups were exposed to 580 µW fluorescent light between 02:00 and 04:00 at night. Daily food and water consumption and weight gains of all animals were followed and recorded, and the application was continued for 14 days. Cardiac blood was collected from all animals with heparinized syringes on the 15th day of the experiment and tumor tissues were removed ambuloc. At the end of the experiment, all animals were sacrificed under ether anesthesia. Results: The MDA and GSH parameters in the cardiac blood taken from the subjects were examined and the diameters of the tumor tissues were measured and examined under a light microscope. Weight change in all groups was not statistically significant (p>0.05). It was found that the increases and decreases in the MDA and GSH values of the light and dark groups were not statistically significant (p>0.05). It was determined that there was no statistically significant difference between the tumor diameters of the control light groups and the tumor diameters of the other light groups (p> 0.05). While the difference between the control of dark groups and the tumor diameters of Group K2 was not statistically significant (p>0.05), the increase in tumor diameter of the subjects of Group K3 and Group K4 was found to be statistically significant (p<0.05). Conclusion: As a result; in this study, which investigated the effects of melatonin on experimental EST in dark and light environments, it was revealed that it did not show any positive effect on MDA and GSH levels.

Except for one tropical African species, the Rosa L. species (roses; Rosoideae: Rosaceae) has 150–200 species that are extensively dispersed throughout temperate and subtropical ecosystems of the northern hemisphere. The fact that Central Asia is the rose's native continent is underlined in numerous sources. A quarter of the rose species are found in Europe and North America, while nearly half are found in Asia. Rosa damascene Mill is the species utilized to obtain rose oil, even though there are 24 types of roses registered in Turkey's flora. Rosa damascene, also referred to as the Damascus Rose, Pink Oil Rose, Oil Rose, and Isparta Rose Rose is a perennial, thorny, intensely perfumed, pink-hued, half-layered, and winter-hardy shrub that only blooms in the spring. The range of products is also increasing due to the demand for roses and rose products in this sector. Many products are being developed in the field of nutrition, cleaning, and cosmetics. The aim of this study is to investigate the effects of wild rose plants in the field of health and to expand their use. However, it is thought that increasing the variety of products obtained from the wild rose plant may contribute to the country's economy. The aim of the study is to investigate the use of wild rose plant in our country and in other countries, to show in which diseases it is used and to determine its contribution to the economy of the countries.

Despite the emergence of COVID 19 since 20019 and despite the many studies that researchers have raced to uncover the truth about this virus, there is still great ambiguity in everything related to this virus, especially its behavior inside the human body and the body’s reaction to it. The body reaction to COVID 19 differ greatly from one individual to anther in terms of its type and severity. Hence the importance of this review, as if we understand the changes that this virus causes in the human body and are able to measure its bioindicators, this gives us the ability to understand the behavior of this virus inside the body and thus enables us to overcome it. The investigation of different biomarkers induced by COVID 19 infection will open the dour to the researchers to understand the molecular mechanism of viral infection gives new diagnostic tools for the viral infection and gives the researcher a chance for discovering new strategies for COVID 19 treatment and prevention, and invention of new pharmatheutical products for viral treatment.

Diabetes mellitus is a chronic metabolic ailment caused due to complex interactions of genetic and environmental factors (dietary and lifestyle). It causes remarkable morbidity and mortality due to microvascular (retinopathy, nephropathy, and neuropathy) and macrovascular (heart attack, peripheral vascular disease, and stroke) complications. Treatment of microvascular complications focuses on blood sugar control. Although preventing macrovascular complications requires correcting classical cardiovascular risk factors that involve insulin resistance (metabolic) syndrome. The use of traditional drugs adopts several antidiabetic remedies. These drugs are effectivebecause most of these drugs are taken by patients for their entire life and causeseveral adverse effects like diarrhoea, abdominal distention, and flatulence emanate by intaking these drugs. Due to these restrictions,there is a need to explore management strategies in medicinal plants with cost-effective antidiabetic potentials and fewer or negligible side effects. Applying traditional medicine for diabetes and its associated complications has received increasing attention. This review explores the antidiabetic potential of some commonly and extensively used phytochemicals obtained from traditional medicinal plants.

In the fields of medicine and pharmaceuticals, a family of compounds known as Schiff bases (SB) plays an important part. Schiff base metal complexes are known to display a broad range of biological activities, each of which is unique in comparison to the others. Anticonvulsants, antibacterial agents, antifungal agents, anticancer agents, antiviral agents, and HIV-fighting medicines are all included in this area of pharmaceuticals. It is general information that the search for new medications and the creation of new medicines is a constant endeavor for scientists and researchers. This is true both in terms of the hunt for new medicines and the manufacturing of new medicines. Antibiotics are losing their effectiveness as microorganisms develop resistance to the drugs that treat them, thus there is a pressing need to discover new substances that might combat this problem. Because of this, the focus of this study was on Schiff bases that had just recently been identified, as well as the metal complexes of those bases that had these qualities.

Stem cells are unique and highly powerful cells, which have immense potential for treating various conditions. There are different types of stem cells based on the sources they are derived from and also based on their ability to differentiate into other types of cells. The detailed study of stem cells is important for scientists to understand how the cells grow and differentiate, and how the human body works on a cellular level. In addition to the research interest in stem cells, the clinical applications of stem cells are increasing constantly. Stem cells can be induced to change into new cells of specific tissues or organs, which can then be used for treating diseases. There are already a few established stem cell therapies, and many more in clinical trials.

Background and Objectives: The present study was designed to assess the antileprotic effectiveness of some bioactive natural compounds towards enoyl acyl carrier protein reductase inhibition. Leprosy still constitutes a global pandemic in spite of long years of discovery. The current therapy option is multi-drug treatment using a combination of Dapsone, Rifampicin and Clofazimine. However, mycobacterium leprae counteracted by mutating the drug targets which necessitates the search for novel targets. One such target is enoyl acyl carrier protein reductase that mediates the fatty acid biosynthesis. Materials and Methods: Multiple (14) ligands of natural origin were drawn from PubChem database and their ADMET parameters were preicted using ADMETLab 2.0 webserver. After, the ligands were docked against the enzyme (PDB ID: 2NTV) at its active site using iGEMDOCK software. Results: ADMET parameters of the tested ligands proven to be accepted by Lipinski's rule of five except for two ligands. Furthermore, molecular docking results revealed that all of the tested compounds showed better binding energy than the reference drug Dapsone. The best of which was silymarin. Conclusion: The tested natural ligands have the capability to control M.leprae.

The foremast threats to human health from heavy metals are related with use tobacco when inserted in the human body by smoking ( shisha and cigarette ) or chewable like shammah which is harm of health. The tobacco species have been collected from different places, natural or included in the installation of some of the species sold in the markets. The samples were analyzed by wet digestion method and standardized. International protocols were followed for the preparation of material and analysis of heavy metals contents and analyzed by Inductively coupled plasma spectrometer Model-Varian720 ES in center Laboratory in Meteorology, Environment and Arid Land Agriculture, and Center of Excellence in Environmental Studies, King Abdulaziz University (KAU). Results obtained using ICP-OES technique for determination of heavy metals in Tobacco products. Through this study the results were shown the heavy metals which found in tobacco samples is clearly. the objective of the study showing the concentrative the heavy metals in tobacco and compared with levels of heavy metals allowing in the World Health Organization (WHO ). What the results indicate is the seriousness of the presence of heavy metals, which cause serious diseases such as cancer and failure in most organs. The use of tobacco should be abandoned.

The non-coding elements that control transcription are found in the chromatin structure of organisms. Recent findings identify the non-coding regulatory elements (e.g., enhancers, silencers, promoters) that control transcription and examine their respective protein interactions. The multiple topological environment limitations, including interactions of promoter-enhancer and specific enhancer-bound proteins with variable promoter compatibility, begin to shape a picture. These transcription factors and co-factors contribute to various expressions based on which enhancers and promoters are found inside sequences. A novel trait of transcription factors and co-factors establishes nuclear microenvironments or membranes compartments with phase-separated liquid characteristics. These settings are capable of enriching some proteins and tiny molecules at the expense of others. To better understand gene regulation