Nutritional Neuroscience

Journal Information
ISSN / EISSN: 1028415X / 14768305
Published by: Informa UK Limited
Total articles ≅ 1,541

Latest articles in this journal

Maryam Moghimian, Sohrab Azin, Seyed Sajjad Alavi –Kakhki, Masoumeh Kourosh-Arami, , Farimah Beheshti, Masoumeh Fani
Published: 21 November 2022
Nutritional neuroscience pp 1-10; https://doi.org/10.1080/1028415x.2022.2145423

Abstract:
The present study focused on examining the impact of vitamin C (Vit C) administration on the function of memory and the status of oxidative stress (OS) in the hippocampal area of the brain using an unpredictable chronic mild stress (UCMS) model in rats. To this end, 50 male Wistar rats (11-12 weeks of age at the start of the study) were assigned to five groups of six animals, including control, UCMS, UCMS + Vit C 50 mg/Kg, UCMS + Vit C 100 mg/Kg, and UCMS + Vit C 400 mg/Kg. The animals received daily intraperitoneal injections of Vit C at a certain time (9 am) before the initiation of a stressor. UCMS, including a progression of typical stressors, was applied for four weeks. Subsequently, using the passive avoidance (PA) and Morris water maze (MWM) tests were performed to investigate learning and memory. Eventually, hippocampal tissues were evaluated in terms of OS criteria. The results revealed that the latency to enter the dark chamber (P < 0. 01 and P < 0.05, PA test) and the time spent in the target quadrant (P < 0.0001, MWM test) were shorter in the UCMS group, while latency to discover the platform was longer (P < 0.05 and P < 0.001, MWM test) compared to the control group. However, UCMS decreased the content of thiol (P < 0.0001), as well as the activities of catalase (P < 0.0001) and superoxide dismutase (P < 0.0001), whereas the concentration of malondialdehyde (P < 0.01) increased in the hippocampal region of the brain in comparison to the control group. Interestingly, Vit C treatment reversed the mentioned effects of UCMS. Therefore, the latency to enter the dark chamber (P < 0. 05 and P < 0.01,1 and 24 h after the shock, PA test, UCMS + Vit C 400) and the time spent in the target quadrant (P < 0. 01 and P < 0.05, MWM test, UCMS + Vit C 400 and UCMS + Vit C 100, respectively) were longer in the UCMS + Vit C groups. Moreover, Vit C increased the content of thiol (P < 0.05, UCMS + Vit C 400), as well as the activity of catalase (P < 0.001, UCMS + Vit C 400) and superoxide dismutase (P < 0.0001, UCMS + Vit C 400, UCMS + Vit C 100), whereas the concentration of malondialdehyde (P < 0. 05 and P < 0.01, UCMS + Vit C 100, UCMS + Vit C 400) decreased in the hippocampal region of the brain in comparison to the UCMS group. Overall, these results suggest that Vit C could reverse UCMS-induced learning and memory impairment possibly through the modulation of brain OS.
Cheng Peng, Lijie Gao, Kongyuan Wu, Xin Jiang, Xiwen Chen, Changling Li, Wenjing Ge, Li He,
Published: 17 November 2022
Nutritional neuroscience pp 1-10; https://doi.org/10.1080/1028415x.2022.2143958

Abstract:
Migraine is a highly prevalent headache disorder, and intake of various nutrients and special diets may improve migraine symptoms. We aimed to clarify the association between nutritional status and...
, Laurence Jacquot, Gérard Brand
Published: 17 November 2022
Nutritional neuroscience pp 1-11; https://doi.org/10.1080/1028415x.2022.2145425

Abstract:
Objectives: Odor hedonic perception is well known to exhibit great variability and to depend on several parameters, i.e. stimulus, context, and subject characteristics. As hedonic perception (pleasant/unpleasant character) of food odors is considered one of the most prominent dimensions in eating behavior, the question of hedonic variability in this context arises. Thus, the aim of the present study was to compare odor hedonic ratings in three populations with regard to diet (i.e. omnivore, vegetarian, and flexitarian diets). Methods: Four categories of odors were compared: meat, vegetable, other food, and non-food odors. Results: The results showed that vegetarian and flexitarian individuals rated meat odors as more unpleasant than omnivores, while no significant difference was found for other categories of odors. Discussion: The question of whether the diet influences the hedonic perception or/and inversely is discussed, regarding several aspects of food consumption such as eating disorders, food education, … and could further serve to manage eating behaviors. Practical applications: This study evidenced that vegetarians and flexitarians specifically rated meat odors as being more unpleasant than those of omnivores. Because of the growing number of vegetarians and flexitarians in the general population, it could be suggested to take into account the odor hedonic perception (especially regarding food odors) in studies related to diets. Besides, the present results could further serve research in several aspects of food consumption such as eating disorders (anorexia, bulimia … etc.) or food education as well as the management of eating behaviors, especially in an elderly population.
, Yasemin Akdevelioğlu
Published: 17 November 2022
Nutritional neuroscience pp 1-13; https://doi.org/10.1080/1028415x.2022.2146843

Abstract:
Nutrition is an important risk factor for both Multiple sclerosis (MS) development and post-diagnosis disease prognosis. However, it is important to evaluate the diet as a whole instead of consider...
Published: 14 November 2022
Nutritional neuroscience pp 1-10; https://doi.org/10.1080/1028415x.2022.2144204

Abstract:
The metabolic syndrome is associated with cardiovascular diseases and cognitive decline. The egg protein hydrolysate NWT-03 has shown to improve cardiovascular risk factors in humans. This study in...
Xue-Lian Meng, Jing-Su Xue, Shu-Jie Su, Jiang-Min Gou, Jing Lu, ,
Published: 12 November 2022
Nutritional neuroscience pp 1-15; https://doi.org/10.1080/1028415x.2022.2145426

Abstract:
The seed embryo of Nelumbo nucifera Gaertn. is a famous traditional Chinese medicine and food which is considered conducive to the prevention of Alzheimer's disease (AD). In this study, the effect and mechanism of TASENN (total alkaloids from the seed embryo of Nelumbo nucifera Gaertn.) on AD mice and amyloid-β (Aβ) injured PC12 cells were evaluated. HPLC-UV analysis showed that the extracted TASENN (purity = 95.6%) mainly contains Liensinine, Isoliensinine, and Neferine (purity was 23.01, 28.02, and 44.57%, respectively). In vivo, oral treatment with TASENN (50 mg/kg/day for 28 days) improved the learning and memory functions of APP/PS1 transgenic mice, ameliorated the histopathological changes of cortical and hippocampal neurons, and inhibited neuronal apoptosis. We found that TASENN reduced the phosphorylation of Tau and the formation of neurofibrillary tangles (NFTs) in APP/PS1 mouse brain. Moreover, TASENN down-regulated the expression of APP and BACE1, ameliorated Aβ deposition, and inhibited microglial proliferation and aggregation. The elevated protein expression of CaM and p-CaMKII in APP/PS1 mouse brain was also reduced by TASENN. In vitro, TASENN inhibited the apoptosis of PC12 cells injured by Aβ25–35 and increased the cell viability. Aβ25–35-induced increase of cytosolic free Ca2+ level and high expression of CaM, p-CaMKII, and p-Tau were decreased by TASENN. Our findings indicate that TASENN has a potential therapeutic effect on AD mice and a protective effect on PC12 cells. The anti-AD activity of TASENN may be closely related to its negative regulation of the CaM pathway. GRAPHICAL ABSTRACT
Correction
Published: 8 November 2022
Nutritional neuroscience pp 1-1; https://doi.org/10.1080/1028415x.2022.2142761

Abstract:
Article title: The microbiome-gut-brain axis in nutritional neuroscienceAuthors: Schellekens, H., Ribeiro, G., Cuesta-Marti, C., & Cryan, J.F.Journal: Nutritional NeuroscienceDOI: http://dx.doi.org...
, Flávia Suelen De Oliveira Pereira, Daiana Silva Ávila, Celito Crivellaro Guerra, Letícia Flores da Silva, Carlos Henrique Junges, Marco Flôres Ferrão, Ana Maria Bergold
Published: 7 November 2022
Nutritional neuroscience pp 1-12; https://doi.org/10.1080/1028415x.2022.2140394

Abstract:
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the presence of aggregated amyloid-β (Aβ) peptides. Several natural compounds have been proposed against this disease and g...
, , Nada A. H. Soliman, Amira M. Omar, Eman A. Allam
Published: 7 November 2022
Nutritional neuroscience pp 1-11; https://doi.org/10.1080/1028415x.2022.2140395

Abstract:
The deposition of β-amyloid plaques, either due to their over-production or insufficient clearance, is an important pathological process in cognitive impairment and dementia. Icariin (ICA), a flavonoid compound extracted from Epimedium, has recently gained attention for numerous age-related diseases, such as neurodegenerative diseases. We aimed to explore the possible neuro-protective effect of ICA supplementation in colchicine-induced cognitive deficit rat model and exploring its effect on the β-amyloid proteolytic enzymes. The study included four groups (10 rats each): normal control, untreated colchicine, colchicine + 10 mg/kg ICA, and colchicine + 30 mg/ kg ICA. Results revealed that intra-cerebro-ventricular colchicine injection produced neuronal morphological damage, β amyloid deposition, and evident cognitive impairment in the behavioral assessment. Icariin supplementation in the two doses for 21 days attenuated neuronal death, reduced the β amyloid levels, and improved memory consolidation. This was associated with modulation of the proteolytic enzymes (Neprilysin, Matrix Metalloproteinase-2, and insulin-degrading enzyme) concluding that β-amyloid enzymatic degradation may be the possible therapeutic target for ICA.
Zhuanzhuan Liu, Hongxiang Sun, Shihong Xu, Hanying Wang, Zhiwei Zhang, Yanxia Wei, Yanbo Kou,
Published: 7 November 2022
Nutritional neuroscience pp 1-11; https://doi.org/10.1080/1028415x.2022.2142129

Abstract:
Consumption of a modern Western-type high-fat low-fiber diet increases the risk of obesity. However, how a host responds to such a diet, especially during the early period of dietary transition fro...
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