Journal of Surgery and Medicine
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Journal of Surgery and Medicine
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Journal of Surgery and Medicine, Volume 7, pp 245-248; https://doi.org/10.28982/josam.7771
Abstract:
Background/Aim: JAK2 is a gene that provides instructions for making a protein called Janus kinase 2, which is involved in the signaling process that regulates the growth and division of cells. Variations in the JAK2 gene have been associated with several different diseases, including certain blood disorders like myeloproliferative neoplasms (MPNs) and ulcerative colitis (UC). The exact reason for ulcerative colitis is not fully understood. This study aimed to examine the possible role of JAK2 V617F mutation in the etiopathogenesis of ulcerative colitis. Methods: The included patients were selected with UC and with signs of thrombosis. The DNA isolation was carried out from peripheral blood for all included patients. RT-qPCR methods were used to find JAK2 V617F mutations in UC patients with signs of thrombosis. Results: 73.3% of the included patients in this study had bloody diarrhea and 80% had abdominal pain. Also, the JAK2 V617F mutation rate was detected in 6.6% of the patients included in the study. Conclusion: In this study, it was found that the V617F mutation was relatively rare in ulcerative colitis patients and there was no correlation with the JAK2 V617F mutation in most of the ulcerative colitis cases with thrombotic symptoms. '+st+' Liu M, Zhu W, Wang J, Zhang J, Guo X, Wang J, et al. Interleukin-23 receptor genetic polymorphisms and ulcerative colitis susceptibility: A meta-analysis. Clin Res Hepatol Gastroenterol. 2015 Sep;39(4):516-25. doi: 10.1016/j.clinre.2014.10.009. DOI: https://doi.org/10.1016/j.clinre.2014.10.009 Sarlos P, Kovesdi E, Magyari L, Banfai Z, Szabo A, Javorhazy A, et al. Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature. World J Gastrointest Pathophysiol. 2014 Aug 15;5(3):304-21. doi: 10.4291/wjgp.v5.i3.304. DOI: https://doi.org/10.4291/wjgp.v5.i3.304 Li J, Tian H, Jiang HJ, Han B. Interleukin-17 SNPs and serum levels increase ulcerative colitis risk: a meta-analysis. World J Gastroenterol. 2014 Nov 14;20(42):15899-909. doi: 10.3748/wjg.v20.i42.15899. DOI: https://doi.org/10.3748/wjg.v20.i42.15899 Obayashi T, Okamoto S, Hisamatsu T, Kamada N, Chinen H, Saito R, et al. IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut. 2008 Dec;57(12):1682-9. doi: 10.1136/gut.2007.135053. DOI: https://doi.org/10.1136/gut.2007.135053 Podolsky DK. Inflammatory bowel disease. N Engl J Med. 2002 Aug 8;347(6):417-29. doi: 10.1056/NEJMra020831. DOI: https://doi.org/10.1056/NEJMra020831 Mitus AJ, Schafer AI. Thrombocytosis and thrombocythemia. Hematol Oncol Clin North Am. 1990 Feb;4(1):157-78. DOI: https://doi.org/10.1016/S0889-8588(18)30511-2 Gilbert HS, Dameshek W. The myeloproliferative disorders. Dis Mon. 1970 Oct:1-52. doi: 10.1016/s0011-5029(70)80012-8. DOI: https://doi.org/10.1016/S0011-5029(70)80012-8 Simons CM, Stratton CW, Kim AS. Peripheral blood eosinophilia as a clue to the diagnosis of an occult Coccidioides infection. Hum Pathol. 2011 Mar;42(3):449-53. doi: 10.1016/j.humpath.2010.09.005. DOI: https://doi.org/10.1016/j.humpath.2010.09.005 Horsted F, West J, Grainge MJ. Risk of venous thromboembolism in patients with cancer: a systematic review and meta-analysis. PLoS Med. 2012;9(7):e1001275. doi: 10.1371/journal.pmed.1001275. DOI: https://doi.org/10.1371/journal.pmed.1001275 Streiff MB, Holmstrom B, Angelini D, Ashrani A, Elshoury A, Fanikos J, et al. Cancer-Associated Venous Thromboembolic Disease, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2021 Oct 15;19(10):1181-1201. doi: 10.6004/jnccn.2021.0047. Miehsler W, Reinisch W, Valic E, Osterode W, Tillinger W, Feichtenschlager T, et al. Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism? Gut. 2004 Apr;53(4):542-8. doi: 10.1136/gut.2003.025411. DOI: https://doi.org/10.1136/gut.2003.025411 Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N, Swanton S, et al; Cancer Genome Project. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005 Mar 19-25;365(9464):1054-61. doi: 10.1016/S0140-6736(05)71142-9. DOI: https://doi.org/10.1016/S0140-6736(05)71142-9 James C, Ugo V, Le Couédic JP, Staerk J, Delhommeau F, Lacout C, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005 Apr 28;434(7037):1144-8. doi: 10.1038/nature03546. DOI: https://doi.org/10.1038/nature03546 Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005 Apr 28;352(17):1779-90. doi: 10.1056/NEJMoa051113. DOI: https://doi.org/10.1056/NEJMoa051113 Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, Huntly BJ, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005 Apr;7(4):387-97. doi: 10.1016/j.ccr.2005.03.023. DOI: https://doi.org/10.1016/j.ccr.2005.03.023 Steensma DP, Dewald GW, Lasho TL, Powell HL, McClure RF, Levine RL, et al. The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes. Blood. 2005 Aug 15;106(4):1207-9. doi: 10.1182/blood-2005-03-1183. DOI: https://doi.org/10.1182/blood-2005-03-1183 Campbell PJ, Scott LM, Buck G, Wheatley K, East CL, Marsden JT, et al; United Kingdom Myeloproliferative Disorders Study Group; Medical Research Council Adult Leukaemia Working Party; Australasian Leukaemia and Lymphoma Group. Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study. Lancet. 2005 Dec 3;366(9501):1945-53. doi: 10.1016/S0140-6736(05)67785-9. DOI: https://doi.org/10.1016/S0140-6736(05)67785-9 Lindauer K,...
Journal of Surgery and Medicine, Volume 7, pp 239-244; https://doi.org/10.28982/josam.7748
Abstract:
Background/Aim: Azoospermia is defined as the absence of sperm in semen and is one of the most common causes of male infertility, with a prevalence of 10-15% in infertile men. Conventional methods for semen analysis do not provide a clear understanding of the etiology of azoospermia. Although testicular biopsy may exclude obstructive cases, non-obstructive azoospermia (NOA) treatment is limited due to a limited understanding of the underlying molecular mechanisms. Analysis of genetic alterations in azoospermia patients compared to the fertile population may be a valuable tool for determining diagnostic biomarkers for male infertility. This study aims to use bioinformatic tools to determine the top candidates in certain pathways altered in azoospermia. Methods: Expression data (GSE108886) of the differential testicular transcriptome in patients with NOA was selected from the Gene Expression Omnibus (GEO) database. Testicular RNA was harvested from azoospermia patients (n=11) and healthy controls (n=1, pooled sample). The differentially expressed genes (DEGs) were examined using GEO2R software. Biological pathways were identified through the Kyoto Encyclopedia of Genes and Genomes (KEGG). Construction of the protein network and detection of hub genes were conducted in the STRING database. Data validation was performed via ELISA assay for the FOXO3 gene in obstructive and NOA patients. Significance was set at P-value <0.05. Results: In NOA patients, 2115 genes were upregulated, and 1753 genes were downregulated compared to the control group. Ninety-one genes involved in spermatogenesis were downregulated. KEGG analysis revealed that the glucagon signaling, AMPK signaling, insulin and estrogen signaling, and oocyte meiosis pathways were upregulated, while the regulation of actin cytoskeleton, MAPK signaling pathway, focal adhesion, and chemical carcinogenesis – reactive oxygen species pathways were downregulated. Downstream genes with the highest score were PSMA4, PSMA6, PSMC1, PSME4, and UBA52, which are responsible for the ubiquitin-dependent protein degradation. The top hub genes with increasing expression were RPS18, RPS2, and RPS4X Conclusion: Although hub genes selected within the altering pathways may serve as a diagnostic tool for NOA, further validation of the presented data is necessary, as protein-protein interactions may not reflect alterations in gene expression in vivo. function ready(callback){ // in case the document is already rendered if (document.readyState!='loading') callback(); // modern browsers else if (document.addEventListener) document.addEventListener('DOMContentLoaded', callback); // IE <= 8 else document.attachEvent('onreadystatechange', function(){ if (document.readyState=='complete') callback(); }); } ready(function(){ var abstract = document.getElementById("abstract"); //declare your possible strings in vars let st = innerHTML; st = st.replace(//g,""); st = st.replace(/<\/p>/g,""); st = st.replace(//g,""); st = st.replace(/<\/strong>/g,""); st = st.replace(/ /g,""); let title = "Background/Aim:"; if(st.includes(title)){ st = st.replace(title, ""+title+" "); } else{ title = "Aim:"; st = st.replace(title, ""+title+""); } let titles = ["Methods:", "Conclusion:", "Results:"]; titles.forEach((title, ndx) => { //console.log(title); st = st.replace(title, " "+title+""); }); //console.log(st); innerHTML = ''+st+''; }); Downloads Download data is not yet available. References Katz DJ, Teloken P, Shoshany O. Male infertility-the other side of the equation. Aust Fam Phys. 2017;46(9):641-6. Ghieh F, Mitchell V, Mandon-Pepin B, Vialard F. Genetic defects in human azoospermia. Bas Clin Androl. 2019;29(1):1-16. Dong M, Li H, Zhang X, Tan J. Weighted correlation gene network analysis reveals new potential mechanisms and biomarkers in non-obstructive azoospermia. Frontiers in Genetics. 2021;12:617133. Malcher A, Rozwadowska N, Stokowy T, Kolanowski T, Jedrzejczak P, Zietkowiak W, et al. Potential biomarkers of non-obstructive azoospermia identified in microarray gene expression analysis. Fertil Steril. 2013;100(6):1686-94. e7. Peña VN, Kohn TP, Herati AS. Genetic mutations contributing to non-obstructive azoospermia. Best Prac Rest CL EN. 2020;34(6):101479. Dodé C, Hardelin J-P. Kallmann syndrome. Eur J Hum Genet. 2009;17(2):139-46. Batista RL, Costa EMF, Rodrigues AdS, Gomes NL, Faria Jr JA, Nishi MY, et al. Androgen insensitivity syndrome: a review. Arch Endocrin Metab. 2018;62:227-35. Yatsenko AN, Georgiadis AP, Röpke A, Berman AJ, Jaffe T, Olszewska M, et al. X-linked TEX11 mutations, meiotic arrest, and azoospermia in infertile men. New Engl J Med. 2015;372(22):2097-107. Boroujeni PB, Sabbaghian M, Totonchi M, Sodeifi N, Sarkardeh H, Samadian A, et al. Expression analysis of genes encoding TEX11, TEX12, TEX14 and TEX15 in testis tissues of men with non-obstructive azoospermia. JBRA Assist Reprod. 2018;22(3):185. Massart A, Lissens W, Tournaye H, Stouffs K. Genetic causes of spermatogenic failure. Asian J Androl. 2012;14(1):40. Marchetti F, Wyrobek AJ. Mechanisms and consequences of paternally‐transmitted chromosomal abnormalities. Birth Defects Res C. 2005;75(2):112-29. Adler I-D. Comparison of the duration of spermatogenesis between male rodents and humans. Mutat Res-Fund Mol M. 1996;352(1-2):169-72. Cannarella R, Condorelli RA, Mongioì LM, La Vignera S, Calogero AE. Molecular biology of spermatogenesis: novel targets of apparently idiopathic male infertility. Int J Mol Sci 2020;21(5):1728. Xia W, Mruk DD, Lee WM, Cheng CY. Unraveling the molecular targets pertinent to junction restructuring events during spermatogenesis using the Adjudin-induced germ cell depletion model. The J Endoc. 2007;192(3):563. Zheng H, Zhou X, Li D-k, Yang F, Pan H, Li T, et al. Genome-wide alteration in DNA hydroxymethylation in the sperm from...
,
Dilek Atik,
Fulya Köse
Journal of Surgery and Medicine, Volume 7; https://doi.org/10.28982/josam.1114138
Abstract:
Dermoid cysts are one of the most common causes of ovarian torsion. The causes of acute abdominal pain are mostly caused by the diagnosis of acute appendicitis, acute pancreatitis, and mesenteric ischemia, and the incidence of ovarian torsion is not known exactly. Although ovarian torsion is very rare, it ranks first among the indications for gynecological emergency surgery. A rare case of a non-ruptured dermoid cyst causing ovarian torsion in the emergency room is presented.
Mehmet Köse,
,
,
Muhammet Çağatay Engin,
Ömer Selim Yıldırım,
Alperen Zeynel
Journal of Surgery and Medicine, Volume 7, pp 225-228; https://doi.org/10.28982/josam.7745
Abstract:
Background/Aim: Open reduction (OR) and Pemberton’s periacetabular osteotomy (PPO) are efficient and reliable methods for treating late-diagnosed developmental dysplasia of the hip. However, various studies have reported an avascular necrosis (AVN) rate of up to 80% with this technique, which is increased in Tönnis type 4 hips. In this study, we hypothesized that femoral shortening osteotomy (FSO) would reduce the rates of AVN by decreasing the post-reduction pressure on the femoral head. Methods: In this retrospective cohort study, we reviewed patients who had undergone OR and PPO between 2006 and 2016. Only hips with Tönnis type 4 dislocation were included. The subjects were divided into two groups: Group 1, who had undergone OR+PPO, and Group 2, who had undergone OR+PPO+FSO. The Kalamchi-MacEwen system was used for AVN classification. The groups were compared regarding the pre- and postoperative acetabular indices and the rate of AVN and other complications. Results: We included 76 hips of 50 patients who met the inclusion criteria in the study. Group 1 consisted of 46 hips of 32 patients, and Group 2 consisted of 30 hips of 18 patients. The mean age of the patients was 31.5 months, and Group 1 (30 months) had a significantly lower mean age than Group 2 (34 months) (P=0.019). There were no statistically significant differences regarding the pre- and postoperative acetabular indices. In Group 1, 27 (58%) out of 46 hips had AVN, whereas the rate of AVN was ten (30%) out of 30 hips in Group 2. Out of the 27 hips with AVN in Group 1, 12 were type 1, five were type 2, and ten were type 3. Out of the 10 hips with AVN in Group 2, seven were type 1, two were type 2, and one was type 4. There was a statistically significant difference between the groups regarding the rates of AVN, with Group 2 having better outcomes not only in comparison to the rate of all AVNs (P=0.031) but also in comparison to high-grade AVNs (P=0.042) (Grade 3 and Grade 4). Conclusion: Performing FSO with OR and PPO provides a significant decrease in the rate of AVN without altering acetabular development after surgery. '+st+' Patel H, Canadian Task Force on Preventive Health Care. Preventive health care, 2001 update: screening and management of developmental dysplasia of the hip in newborns. CMAJ. 2001 Jun 12;164(12):1669-77. PMID: 11450209; PMCID: PMC81153. Chen Q, Deng Y, Fang B. Outcome of one-stage surgical treatment of developmental dysplasia of the hip in children from 1.5 to 6 years old. A retrospective study. Acta Orthop Belg. 2015 Sep;81(3):375-83. PMID: 26435230. Danielsson L. Late-diagnosed DDH: a prospective 11-year follow-up of 71 consecutive patients (75 hips). Acta Orthop Scand. 2000 Jun;71(3):232-42. doi: 10.1080/000164700317411816. PMID: 10919293. Wang TM, Wu KW, Shih SF, Huang SC, Kuo KN. Outcomes of open reduction for developmental dysplasia of the hip: does bilateral dysplasia have a poorer outcome? J Bone Joint Surg Am. 2013 Jun 19;95(12):1081-6. doi: 10.2106/JBJS.K.01324. PMID: 23783204. Yagmurlu MF, Bayhan IA, Tuhanioglu U, Kilinc AS, Karakas ES. Clinical and radiological outcomes are correlated with the age of the child in single-stage surgical treatment of developmental dysplasia of the hip. Acta Orthop Belg. 2013 Apr;79(2):159-65. PMID: 23821967. Herold HZ, Daniel D. Reduction of neglected congenital dislocation of the hip in children over the age of six years. J Bone Joint Surg Br. 1979 Feb;61(1):1-6. doi: 10.1302/0301-620X.61B1.422627. PMID: 422627. Schoenecker PL, Strecker WB. Congenital dislocation of the hip in children. Comparison of the effects of femoral shortening and of skeletal traction in treatment. J Bone Joint Surg Am. 1984 Jan;66(1):21-7. PMID: 6690440. Groves EH. The treatment of congenital dislocation of the hip-joint, with special reference to open operative reduction. The Robert Jones birthday volume: Oxford University Press, London; 1928. p. 73-96. Ombrédanne L, Fèvre DM. Précis clinique et opératoire de chirurgie infantile: par L. Ombrédanne,... 5e édition... avec la collaboration de Marcel Fèvre: Masson; 1949. Galpin RD, Roach JW, Wenger DR, Herring JA, Birch JG. One-stage treatment of congenital dislocation of the hip in older children, including femoral shortening. J Bone Joint Surg Am. 1989 Jun;71(5):734-41. PMID: 2732262. Ning B, Yuan Y, Yao J, Zhang S, Sun J. Analyses of outcomes of one-stage operation for treatment of late-diagnosed developmental dislocation of the hip: 864 hips followed for 3.2 to 8.9 years. BMC Musculoskelet Disord. 2014 Nov 28;15:401. doi: 10.1186/1471-2474-15-401. PMID: 25432778; PMCID: PMC4289045. Wenger DR, Lee CS, Kolman B. Derotational femoral shortening for developmental dislocation of the hip: special indications and results in the child younger than 2 years. J Pediatr Orthop. 1995 Nov-Dec;15(6):768-79. doi: 10.1097/01241398-199511000-00009. PMID: 8543606. Akgül T, Bora Göksan S, Bilgili F, Valiyev N, Hürmeydan OM. Radiological results of modified Dega osteotomy in Tönnis grade 3 and 4 developmental dysplasia of the hip. J Pediatr Orthop B. 2014 Jul;23(4):333-8. doi: 10.1097/BPB.0000000000000059. PMID: 24769776. Alassaf N. Predictors of femoral shortening for pediatric developmental hip dysplasia surgery: an observational study in 435 patients. Patient Saf Surg. 2018 Oct 19;12:29. doi: 10.1186/s13037-018-0176-y. PMID: 30377448; PMCID: PMC6194737. Sankar WN, Tang EY, Moseley CF. Predictors of the need for femoral shortening osteotomy during open treatment of developmental dislocation of the hip. J Pediatr Orthop. 2009 Dec;29(8):868-71. doi: 10.1097/BPO.0b013e3181c29cb2. PMID: 19934701. Gholve PA, Flynn JM, Garner MR, Millis MB, Kim YJ. Predictors for secondary procedures in walking DDH. J Pediatr Orthop. 2012 Apr-May;32(3):282-9. doi:...
Alev Esercan,
,
Ferhat Coskun
Journal of Surgery and Medicine, Volume 7, pp 229-233; https://doi.org/10.28982/josam.7637
Abstract:
Background/Aim: The description of placenta accreta spectrum disorder (PAS) has undergone significant changes. However, its association with obstetric morbidity and mortality has become even more important. Therefore, we aimed to assess the histopathologic evaluation of PAS patients who underwent a hysterectomy. Methods: We conducted a retrospective study of all pathology reports from patients with peripartum hysterectomies at Sanliurfa Training and Research Hospital diagnosed with PAS. The study included 45 patients with a cesarean hysterectomy due to a preoperative placenta accreta spectrum disorder diagnosis. Hysterectomy specimens were evaluated based on placental invasion and myometrial defect at the site of the placenta. Results: Out of 45 patients diagnosed with placenta accreta spectrum disorder who underwent a hysterectomy, only 17 (37.8%) had a histological diagnosis supporting the placental invasion. The histological diagnosis was consistent in 20 (44.4%) patients, indicating that the placenta protruded from a uterine wall defect without placental invasion. In eighth (17.8%) patients, the histopathological diagnosis was consistent with a histologically normal placenta. Conclusion: The primary pathology of the disorder is variable, and the main issue is the association of the placenta with defective myometrium. Although a more alarming definition, such as invasion, should be avoided, PAS should not be underestimated due to its high mortality. '+st+' Assoc. Prof in Department of Perinatology, Sanliurfa Education and Research Hospital, Sanliurfa, Turkey, Medical doctor in Department of Pathology, Sanliurfa Education and Research Hospital, Sanliurfa, Turkey Jauniaux E, Ayres-de-Campos D, Diagnosis FPA, Management Expert Consensus P. FIGO consensus guidelines on placenta accreta spectrum disorders: Introduction. Int J Gynaecol Obstet. 2018;140(3):261-4. Epub 2018/02/07. doi: 10.1002/ijgo.12406. PubMed PMID: 29405322. Jauniaux E, Alfirevic Z, Bhide AG, Belfort MA, Burton GJ, Collins SL, et al. Placenta Praevia and Placenta Accreta: Diagnosis and Management: Green-top Guideline No. 27a. BJOG. 2019;126(1):e1-e48. Epub 2018/09/28. doi: 10.1111/1471-0528.15306. PubMed PMID: 30260097. American College of O, Gynecologists, Society for Maternal-Fetal M. Obstetric Care Consensus No. 7: Placenta Accreta Spectrum. Obstet Gynecol. 2018;132(6):e259-e75. Epub 2018/11/22. doi: 10.1097/AOG.0000000000002983. PubMed PMID: 30461695. Carusi DA FK, Lyell DJ, Perlman NC, Aalipour S, Einerson BD, et al Placenta accreta spectrum without placenta previa. Obstetrics & Gynecology.2020;136(3):458-65. Einerson BD, Comstock J, Silver RM, Branch DW, Woodward PJ, Kennedy A. Placenta Accreta Spectrum Disorder: Uterine Dehiscence, Not Placental Invasion. Obstet Gynecol. 2020;135(5):1104-11. Epub 2020/04/14. doi: 10.1097/AOG.0000000000003793. PubMed PMID: 32282597. Jauniaux E, Bhide A. Prenatal ultrasound diagnosis and outcome of placenta previa accreta after cesarean delivery: a systematic review and meta-analysis. Am J Obstet Gynecol. 2017;217(1):27-36. Epub 2017/03/08. doi: 10.1016/j.ajog.2017.02.050. PubMed PMID: 28268196. Kaufmann P BG. Anatomy and genesis of the placenta The physiology of reproduction. 1994;1:441-84. Tantbirojn P, Crum CP, Parast MM. Pathophysiology of placenta creta: the role of decidua and extravillous trophoblast. Placenta. 2008;29(7):639-45. Epub 2008/06/03. doi: 10.1016/j.placenta.2008.04.008. PubMed PMID: 18514815. Strickland S, Richards WG. Invasion of the trophoblasts. Cell. 1992;71(3):355-7. Epub 1992/10/30. doi: 10.1016/0092-8674(92)90503-5. PubMed PMID: 1423599. Wehrum MJ, Buhimschi IA, Salafia C, Thung S, Bahtiyar MO, Werner EF, et al. Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast. Am J Obstet Gynecol. 2011;204(5):411:e1-e11. Epub 2011/02/15. doi: 10.1016/j.ajog.2010.12.027. PubMed PMID: 21316642; PubMed Central PMCID: PMCPMC3136625. Tseng JJ, Chou MM. Differential expression of growth-, angiogenesis- and invasion-related factors in the development of placenta accreta. Taiwan J Obstet Gynecol. 2006;45(2):100-6. Epub 2007/01/02. doi: 10.1016/S1028-4559(09)60205-9. PubMed PMID: 17197348. Earl U, Bulmer JN, Briones A. Placenta accreta: an immunohistological study of trophoblast populations. Placenta. 1987;8(3):273-82. Epub 1987/05/01. doi: 10.1016/0143-4004(87)90051-8. PubMed PMID: 2443908. Lunghi L, Ferretti ME, Medici S, Biondi C, Vesce F. Control of human trophoblast function. Reprod Biol Endocrinol. 2007;5:6. Epub 2007/02/10. doi: 10.1186/1477-7827-5-6. PubMed PMID: 17288592; PubMed Central PMCID: PMCPMC1800852. Timor-Tritsch IE, Monteagudo A, Cali G, Vintzileos A, Viscarello R, Al-Khan A, et al. Cesarean scar pregnancy is a precursor of morbidly adherent placenta. Ultrasound Obstet Gynecol. 2014;44(3):346-53. Epub 2014/06/04. doi: 10.1002/uog.13426. PubMed PMID: 24890256. Copyright (c) 2023 Alev Esercan , Emre Ekmekci , Ferhat Coskun This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
,
Tolga Semerkant,
Oya Yalcin Cok
Journal of Surgery and Medicine, Volume 7; https://doi.org/10.28982/josam.1109449
Abstract:
Pain management significantly reduces mortality by aiding in the effective elimination of secretions after thoracic surgery. We present two cases requiring emergency surgical intervention due to major trauma. Both patients were provided pain control with an intrathoracic approach of the paravertebral block performed by a sterile-clothed anesthetist with a single-shot 20 ml injection of 0.25% bupivacaine from the inner surface to the superior costo-transverse ligament (SCTL). After extubation, the measured VAS score was no higher than 3–4, and the patients could breathe and cough comfortably. The intrathoracic approach may be an effective method to implement for postoperative acute pain.
,
Özlem Bilik,
Aklime Sarıkaya,
,
Şirin Akyıl
Journal of Surgery and Medicine, Volume 7, pp 234-238; https://doi.org/10.28982/josam.7398
Abstract:
Background/Aim: Patients who have undergone brain surgery are at risk of falling. Fear of falling causes an increase in the risk of falling and a decrease in movement and daily life activities. However, no previous research has investigated the fear of falling experienced by patients who have undergone brain surgery or the factors that affect it. This study aims to examine the relationship between fear of falling and pain, cognitive status, functional mobility, anxiety, depression, and socio-demographic and clinical characteristics in patients who have undergone brain surgery. Methods: This cross-sectional study included 115 patients who had undergone brain surgery. The data were collected via a Patient Information Form, the Fear of Falling Scale, the Visual Analogue Scale, the Mini-Mental State Examination, the Itaki Fall Risk Scale, the Hospital Anxiety and Depression Scale, the Glasgow Coma Scale and the Timed Up and Go Test. IBM SPSS 22.0 software was used for descriptive statistics, correlation, and stepwise multiple linear regression analyses. Results: Of the 115 patients, 73.1% were afraid of falling. Multiple linear regression analysis of the fear of falling in patients who had undergone brain surgery reveals that age (β=0.217, P=0.004), number of postoperative mobilizations (β=-0.141, P=0.031), a reported history of falling (β=0.155, P=0.032), the Timed Up and Go Test (β=0.372, P<0.001), and anxiety (β=0.358, P<0.001) were significant predictors of fear of falling. These variables explained 63% of the common variance. Conclusion: Age, number of mobilizations, falling experience, functional mobility, and anxiety level can affect the fear of falling in patients after brain surgery. To mitigate this fear, it is important to plan care with reference to these variables from the time of the brain surgery until the patient is discharged. In addition, there is a need for further studies on falling and the fear of falling after brain surgery. function ready(callback){ // in case the document is already rendered if (document.readyState!='loading') callback(); // modern browsers else if (document.addEventListener) document.addEventListener('DOMContentLoaded', callback); // IE <= 8 else document.attachEvent('onreadystatechange', function(){ if (document.readyState=='complete') callback(); }); } ready(function(){ var abstract = document.getElementById("abstract"); //declare your possible strings in vars let st = innerHTML; st = st.replace(//g,""); st = st.replace(/<\/p>/g,""); st = st.replace(//g,""); st = st.replace(/<\/strong>/g,""); st = st.replace(/ /g,""); let title = "Background/Aim:"; if(st.includes(title)){ st = st.replace(title, ""+title+" "); } else{ title = "Aim:"; st = st.replace(title, ""+title+""); } let titles = ["Methods:", "Conclusion:", "Results:"]; titles.forEach((title, ndx) => { //console.log(title); st = st.replace(title, " "+title+""); }); //console.log(st); innerHTML = ''+st+''; }); Downloads Download data is not yet available. References Denkinger MD, Lukas A, Nikolaus T, Hauer K. Factors associated with fear of falling and associated activity restriction in community-dwelling older adults: A systematic review. Am J Geriatr Psychiatry. 2015;23(1):72–86. doi: 10.1016/j.jagp.2014.03.002. Turhan Damar H, Bilik O, Karayurt O, Ursavas FE. Factors related to older patients’ fear of falling during the first mobilization after total knee replacement and total hip replacement. Geriatr Nurs (Minneap). 2018;39(4):382-7. doi: 10.1016/j.gerinurse.2017.12.003 Doré AL, Yvonne MG, Mercer VS, Shi XA, Renner JB, Joanne MJ, et al. Lower limb osteoarthritis and the risk of falls in a community-based longitudinal study of adults with and without osteoarthritis. Arthritis Care Res (Hoboken). 2015;67(5):633–9. doi:10.1002/acr.22499. Montero-Odasso M, Verghese J, Beauchet O, Hausdorff JM. Gait and cognition: A complementary approach to understanding brain function and the risk of falling. J Am Geriatr Soc. 2012;60(11):2127–36. doi:10.1111/j.1532-5415.2012.04209.x Kushner DS, Amidei C. Rehabilitation of motor dysfunction in primary brain tumor patients. Neuro-Oncology Pract. 2015;2(4):185–91. doi:10.1093/nop/npv019 Dicle A, Simsek AB, Vahaplar A. Investigation of symptoms severity, symptoms clustering and status of interference in the life of patients with primary brain tumors. Int J Basic Clin Stud. 2014;3(1):40–54. Çelik GO, Zıngal H. Beyin cerrahisi kliniğinde yatan hastaların düşme risklerinin ve alınan önlemlerin belirlenmesi. İzmir Katip Çelebi Üniversitesi Sağlık Bilim Fakültesi Derg. 2016;1(1):7–11. Uemura K, Shimada H, Makizako H, Doi T, Tsutsumimoto K, Lee S, et al. Effects of mild cognitive impairment on the development of fear of falling in older adults: A prospective cohort study. J Am Med Dir Assoc. 2015;16(12):1104.e9-1104.e13. doi: 10.1016/j.jamda.2015.09.014. Uemura K, Shimada H, Makizako H, Doi T, Tsutsumimoto K, Yoshida D, et al. Effects of mild and global cognitive impairment on the prevalence of fear of falling in community-dwelling older adults. Maturitas. 2014;78:62–6. doi: 10.1016/j.maturitas.2014.02.018. Uemura K, Shimada H, Makizako H, Yoshida D, Doi T, Tsutsumimoto K, et al. A lower prevalence of self-reported fear of falling is associated with memory decline among older adults. Gerontology. 2012;58(5):413–8. doi: 10.1159/000336988 Borges SDM, Radanovic M, Forlenza OV. Fear of falling and falls in older adults with mild cognitive impairment and Alzheimer's disease. Aging, Neuropsychol Cogn. 2015;22(3):312–21. doi: 10.1080/13825585.2014.933770. Young WR, Williams MA. How fear of falling can increase fall-risk in older adults: Applying psychological theory to...
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Ahmet Gürhan Gürçay,
Atilla Kazancı,
Oktay Gürcan,
Mehmet özgür Özateş
Journal of Surgery and Medicine, Volume 7; https://doi.org/10.28982/josam.1073804
Abstract:
Arachnoid cysts are formed by duplication of the arachnoid membrane between the arachnoid and the pia mater. Although it is very common in intracranial localization, those with spinal location are rare. Extradural arachnoid cysts of the spinal canal are extremely rare pathologies regarded as either congenital or acquired. These cysts, which can develop idiopathic, post-traumatic, and after arachnoiditis, are often detected incidentally. They present with weakness in the extremities, neuropathic pain, paresthesia, or myelopathy. Here we describe the case of a 17-year-old male patient with a history of chronic spinal trauma who attended our clinic with severe low back pain for 7 months.
Journal of Surgery and Medicine, Volume 7; https://doi.org/10.28982/josam.7738
Abstract:
Background/Aim: Postpartum bleeding is a leading preventable cause of maternal death. Prolonged 3rd stage duration of labor and induction agents can increase postpartum bleeding. This study evaluated the effect of using a dinoprostone (PGE2) vaginal insert, a cervical ripening and labor induction agent, on the 3rd stage duration of labor and the amount of postpartum bleeding. Methods: This prospective cross-sectional study involved 301 patients with vaginal delivery between 01.10.2020 and 30.06.2021. Patients were separated into two groups: PGE2+oxytocin (Group A) and only oxytocin (Group B). They were compared in terms of prepartum and postpartum data, 3rd stage duration of labor, and the amount of blood loss in the first 18 h postpartum. Results: The median 3rd stage duration of labor was 8 min in Group A and 7 min in Group B (P=0.009). No significant differences were found between the groups in the amount of postpartum blood loss, percentage changes in hemoglobin and hematocrit values, or when patients were analyzed based on 3rd stage duration of labor (≤10 vs. >10 min). Severe postpartum hemorrhage (≥1000 ml) was associated with decreased gravida, increased body mass index, longer oxytocin use, and prolonged 3rd stage duration of labor in all patients. In Group A, severe postpartum hemorrhage was associated with decreased gravida, increased body mass index, and longer duration of PGE2 use. Conclusion: PGE2 prolonged the 3rd stage duration of labor, but this did not increase postpartum bleeding compared to oxytocin. However, an increase in the duration of PGE2 use was associated with postpartum hemorrhage. Therefore, shortening the duration may be considered in patients with additional risk for postpartum hemorrhage. '+st+' WHO. Trends in maternal mortality 2000 to 2017: estimates by WHO, UNICEF, UNFPA, World Bank Group and the United Nations Population Division [Internet]. World Health Organization, Geneva. 2019. 12 p. Available from: https://www.who.int/reproductivehealth/publications/maternal-mortality-2000-2017/en/ B-Lynch C, Keith LG, Lalonde AB. Postpartum Hemorrhage. 2010. pp.31-42 Shahid A, Rizwan S, Khawaja N. Near miss events frequency and most common causes. Pakistan J Med Heal Sci. 2015;9(3):920–2. WHO. The WHO Near-Miss approach for Maternal Health. World Heal Organ [Internet]. 2011;1–34. Available from: www.who.int/reproductivehealth%0Ahttp://apps.who.int/iris/bitstream/10665/44692/1/9789241502221_eng.pdf WHO. WHO recommendations for the prevention and treatment of postpartum haemorrhage [Internet]. World Health Organization. 2012. 41 p. Available from: http://www.who.int/reproductivehealth/publications/maternal_perinatal_health/9789241548502/en/ Sheldon WR, Blum J, Vogel JP, Souza JP, Gülmezoglu AM, Winikoff B; WHO Multicountry Survey on Maternal and Newborn Health Research Network. Postpartum haemorrhage management, risks, and maternal outcomes: findings from the World Health Organization Multicountry Survey on Maternal and Newborn Health. BJOG. 2014 Mar;121 Suppl 1:5-13. doi: 10.1111/1471-0528.12636. PMID: 24641530. Reale SC, Easter SR, Xu X, Bateman BT, Farber MK. Trends in Postpartum Hemorrhage in the United States From 2010 to 2014. Anesth Analg. 2020 May;130(5):e119-e122. doi: 10.1213/ANE.0000000000004424. PMID: 31567319. Deneux-Tharaux C, Bonnet MP, Tort J. Épidémiologie de l'hémorragie du post-partum [Epidemiology of post-partum haemorrhage]. J Gynecol Obstet Biol Reprod (Paris). 2014 Dec;43(10):936-50. French. doi: 10.1016/j.jgyn.2014.09.023. Epub 2014 Nov 6. PMID: 25447386. Prevention and Management of Postpartum Haemorrhage: Green-top Guideline No. 52. BJOG. 2017 Apr;124(5):e106-e149. doi: 10.1111/1471-0528.14178. Epub 2016 Dec 16. PMID: 27981719. van Ast M, Goedhart MM, Luttmer R, Orelio C, Deurloo KL, Veerbeek J. The duration of the third stage in relation to postpartum hemorrhage. Birth. 2019 Dec;46(4):602-607. doi: 10.1111/birt.12441. Epub 2019 June 19. PMID: 31216383. Combs CA, Laros RK Jr. Prolonged third stage of labor: morbidity and risk factors. Obstet Gynecol. 1991 Jun;77(6):863-7. PMID: 2030858. Taebi M, Kalahroudi MA, Sadat Z, Saberi F. The duration of the third stage of labor and related factors. Iran J Nurs Midwifery Res. 2012 Feb;17(2 Suppl 1):S76-9. PMID: 23833605; PMCID: PMC3696975. Ashwal E, Melamed N, Hiersch L, Wiznitzer A, Yogev Y, Peled Y. The incidence and risk factors for retained placenta after vaginal delivery - a single center experience. J Matern Fetal Neonatal Med. 2014 Dec;27(18):1897-900. doi: 10.3109/14767058.2014.883374. Epub 2014 February 4. PMID: 24417417. Favilli A, Tosto V, Ceccobelli M, Bini V, Gerli S. Risk factors analysis and a scoring system proposal for the prediction of retained placenta after vaginal delivery. Eur J Obstet Gynecol Reprod Biol. 2018 Sep;228:180-185. doi: 10.1016/j.ejogrb.2018.06.033. Epub 2018 June 19. PMID: 29980112. Khireddine I, Le Ray C, Dupont C, Rudigoz RC, Bouvier-Colle MH, Deneux-Tharaux C. Induction of labor and risk of postpartum hemorrhage in low risk parturients. PLoS One. 2013;8(1):e54858. doi: 10.1371/journal.pone.0054858. Epub 2013 January 25. PMID: 23382990; PMCID: PMC3555986. Alfirevic Z, Kelly AJ, Dowswell T. Intravenous oxytocin alone for cervical ripening and induction of labour. Cochrane Database Syst Rev. 2009 October 7;2009(4):CD003246. doi: 10.1002/14651858.CD003246.pub2. PMID: 19821304; PMCID: PMC4164045. Frolova AI, Stout MJ, Tuuli MG, López JD, Macones GA, Cahill AG. Duration of the Third Stage of Labor and Risk of Postpartum Hemorrhage. Obstet Gynecol. 2016 May;127(5):951-956. doi: 10.1097/AOG.0000000000001399. PMID: 27054942. Hannigsberg J, Dupré PF, Carpentier M, Merviel P, Collet M, Dessolle L. Repeated sustained release dinoprostone vaginal inserts in women with unfavorable cervix may increase the risk of postpartum hemorrhage:...
Journal of Surgery and Medicine, Volume 7; https://doi.org/10.28982/josam.7713
Abstract:
Background/Aim: Misoprostol is frequently used as a single agent in pregnancy terminations. However, it increases the risk of uterine rupture in patients who have had previous uterine surgery and terminations due to stillbirths. Therefore, it is used with concern by clinicians. The aim of this study was to evaluate the clinical features of the groups that responded and did not respond to termination treatment with misoprostol in a tertiary center and to investigate its efficacy and safety. Methods: The study design was comprised of a retrospective cohort study. A total of 114 second trimester pregnancies (between 13-24 weeks gestational age) were included in the study. These pregnancies were indicated for termination based on the prenatal diagnosis unit for fetal or maternal causes. According to the International Federation of Gynecology and Obstetrics (FIGO) directions, misoprostol was applied in the following dosages: for 13-17 weeks gestational ages, one tablet per 6 hours; for 18-26 gestational ages, ½ tablet per 6 hours; and for other indications 2 tablets per 3 hours were administered. If the patient had had a previous cesarean operation, all doses were halved. After the first 24 hours, the percentage and demographics results, such as age, body mass index (BMI), gravida, number of cesareans, number of curettages, cervical lengths, BISHOP scores, gestational age, amniotic fluid index, and fetal cardiac beat of the patients with miscarriage, were recorded. Results: The number of cases resulting in miscarriage within 24 hours were 84 (73.7%) and within 48 hours were 14 (12.2%). The total of misoprostol doses used were 8 tablets of 200 mg, mean time until the complete abortion was 17 hours. Sixteen patients required additional treatment, of whom four required Foley catheterization, five required D&E, seven required resting, and no one required a hysterectomy. Uterine rupture occurred in two patients who needed laparotomic surgery. The maternal age (P=0.340), BMI (P=0.790), gravida (P=0.270), previous cesarean history (P=0.390), previous curettage number (P=0.520), cervical length (P=0.380), Bishop score (P=0.190), gestational age (P=0.072), amniotic fluid index (P=0.470) and presence of fetal cardiac beat (P=0.350) were similar between groups Conclusion: Our results indicated that misoprostol is a safe, useful, and effective treatment option for second trimester medical terminations. Caution should be exercised in its use in patients with a history of uterine surgery. '+st+' Gilda S, Stanley H, Susheela S, Elisabeth Å, Iqbal HS. Induced abortion: estimated rates and trends worldwide. Lancet. 2007;370(9595):1338–45. Wildschut H, Both MI, Medema S, Thomee E, Wildhagen MF, Kapp N. Medical methods for mid-trimester termination of pregnancy (Review). 2011 The Cochrane Collaboration. Issue 1. Art. No.: CD005216:1-70. Morris JL, Winikoff B, Dabash R, Weeks A, Faundes A, Gemzell-Danielsson K, et al. FIGO's updated recommendations for misoprostol used alone in gynecology and obstetrics. Int J Gynaecol Obstet. 2017 Sep;138(3):363-6. Tenore, JL. Methods for cervical ripening and induction of labor. American family physician. 2003;67(10):2123-8. El-Refaey H, Calder L, Wheatley, Templeton A. Cervical priming with prostaglandin E1 analogues, misoprostol and gemeprost. Lancet. 1994;343(8907):1207–9. Sanchez-Ramos L, Kaunitz AM, Delke I. Labor induction with 25 microg versus 50 microg intravaginal misoprostol: a systematic review. Obstet Gynecol. 2002;99(1):145-51. Sanchez-Ramos L, Danner CJ, Delke I, Kaunitz AM. The effect of tablet moistening on labor induction with intravaginal misoprostol: a randomized trial.Obstet Gynecol. 2002;99(6):1080-4. Carbonell JLL, Varela L, Valezco A, Tanda R. Vaginal misoprostol for early second trimester abortion. Eur J contrac Rep Health C. 1998;3(2):93-8. Thong KJ, Robertson AJ, Baird DT. A retrospective study of 932 second trimester terminations using gemeprost (16,16 dimethyl-trans delta 2 PGE1 methyl ester). Prostaglandins. 1992;44(1):65–74. Rozenberg P, Chevret S, Chastang C, Ville Y. Comparison of digital and ultrasonographic examination of the cervix in predicting time interval from induction to delivery in women with a low Bishop score. Br J Obstet Gynaecol. 2005;112(2):192–6. Bartha JL, Romero-Carmona R, Martinez-Del Fresno P, Comino-Delgado R. Bishop score and transvaginal ultrasound for preinduction cervical assessment: A randomized clinical trial. Ultrasound Obstet Gynecol. 2005;25(2):155–9. Lo TK, Lau WL, Lai FK, et al. The effect of gestational age on the outcome of second-trimester termination of pregnancies for foetal abnormalities. Prenat Diagn. 2008;28(6):508-11. Vitner D, Deutsch M, Paz Y, et al. Association between gestational age and induction-to-abortion interval in mid-trimester pregnancy termination using misoprostol. Eur J Obstet Gynecol Reprod Biol. 2011;156(2):140-3. Ingraham N, Roberts SC, Weitz TA. Prior family planning experiences of obese women seeking abortion care. Women's Health Issues. 2014;24(1):125-30. Mazouni C, Provensal M, Porcu G, et al. Termination of pregnancy in patients with previous cesarean section. Contraception. 2006;73(3):244-8. Amal G. Shammas, Murad D. Momani Misoprostol for termination of second trimester pregnancy in a scarred uterus Saudi Med J. 2006;27(8):1173-6. Shabana A, Salah H, Kandil M, et al. Termination of mid-trimester pregnancies: misoprostol versus concurrent weighted Foley catheter and misoprostol F1000Research. 2012;1:36–40. Caliskan E, Dilbaz S, Gelisen O, et al. Unsucessful labour induction in women with unfavourable cervical scores: predictors and management. Aust N Z J Obstet Gynecol. 2004;44(6):562–7. Srisomboon J, Pongpisuttinun S. Efficacy of intracervicovaginal misoprostol in...