High-speed scanning interferometric focusing by fast measurement of binary transmission matrix for channel demixing
- 21 May 2015
- journal article
- Published by Optica Publishing Group in Optics Express
- Vol. 23 (11), 14168-87
- https://doi.org/10.1364/oe.23.014168
Abstract
Using the fast measurement of a binary transmission matrix and a digital micromirror device, we demonstrate high-speed interferometric focusing through highly dynamic scattering media with binary intensity modulation. The scanning of speckles for reference optimization gives stable focusing, which can be used for focusing through a fast changing media or two dimensional scanning through a slowly changing scattering media. The system allows dynamic focusing at 12.5 Hz with 1024 input modes, and more than 60 times intensity enhancement. It was tested with a moving diffuser, a mouse brain and skull tissue. The experiment with a live drosophila embryo shows its potential in compensating dynamic scattering in live biological tissue.Keywords
Funding Information
- National Science Foundation (NSF) (1353461, 1429810)
This publication has 35 references indexed in Scilit:
- Multiplexed aberration measurement for deep tissue imaging in vivoNature Methods, 2014
- Adaptive optical two-photon microscopy using autofluorescent guide starsOptics Letters, 2013
- Live imaging using adaptive optics with fluorescent protein guide-starsOptics Express, 2012
- Adaptive optics confocal microscopy using direct wavefront sensingOptics Letters, 2011
- Adaptive optics via pupil segmentation for high-resolution imaging in biological tissuesNature Methods, 2009
- Dynamic aberration correction for multiharmonic microscopyOptics Letters, 2009
- Image-based adaptive optics for two-photon microscopyOptics Letters, 2009
- Adaptive optics in microscopyPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2007
- Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensingProceedings of the National Academy of Sciences of the United States of America, 2006
- Adaptive aberration correction in a confocal microscopeProceedings of the National Academy of Sciences of the United States of America, 2002