#### Publisher Biomedical Research and Therapy

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##### 423 articles
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Quang Van Vu
Published: 30 September 2018
Biomedical Research and Therapy, Volume 5, pp 2708-2711; doi:10.15419/bmrat.v5i9.483

Abstract:Background: Acne fulminans (AF) is a rare disorder, the most severe form of the entire clinical spectrum of acne. It is characterized by the emergence of painful inflammatory nodules that turn into ulcers, concomitant with systemic manifestations. Here, we report for the first time a Vietnamese boy with Acne fulminans successfully treated with prednisolone and ibuprofen. Case presentation: The patient is a 14-year-old male teenager with moderate acne since the age of 13. After a day of swimming, his acne suddenly became inflamed and painful lesions were present on his face and back. He had high fever and polyarthritis, and tests showed leukocytosis, neutrophilia, and elevated C-reactive protein (CRP). Severe infection was diagnosed and treated by addition of antibacterial therapy for a long period, however, the condition did not improve. When called upon to evaluate the patient, we established the diagnosis of acne fulminans and initiated treatment with prednisone (1mg/kg/day) and ibuprofen (500 mg for two times daily). Following this treatment regimen, there was a rapid improvement. Conclusion: Herein, we have reported a Vietnamese boy with typical AF, but delayed diagnosis and treatment because of a rare condition. Our results support the role and benefit of prednisolone for AF treatment.
Mojtaba Khazaei, Zaher Khazaei, Elham Goodarzi, Ali Ghadimi
Published: 29 September 2018
Biomedical Research and Therapy, Volume 5, pp 2697-2702; doi:10.15419/bmrat.v5i9.481

Abstract:Background: Acute ischemic stroke is caused by blockage of a cerebral artery and is also known as cerebrovascular accident (CVA). Recombinant tissue plasminogen activator (rt-PA) therapy is effective in reducing early and long-term neurologic disabilities if it is started quickly. Therefore, the aim of this study was to determine the efficacy of treatment with recombinant tissue plasminogen activators in improving the clinical status of acute ischemic stroke. Methods: The current study was performed as a clinical trial of two groups- treatment and control (n=20 per group). The treatment group consisted of patients who received rt-PA, while the control group consisted of patients who did not receive rt-PA. For each group, evaluation of neurological disabilities following ischemic stroke was based off the National Institutes of Health Stroke Scale (NIHSS), for early assessment of disability on the third day of treatment), and off the modified Rankin Scale (MRS) at 90 days after stroke. The drug effect criterion was used to reduce the neurological disability or the difference in NIHSS on day 3 after treatment. Also, the duration of onset of symptoms until the arrival of the patients to the emergency room (ER), as well as the risk factors, complications and number of deaths in both groups, were recorded. Data obtained were analyzed by SPSS software. Results: The results of the study showed that the mean of ER arrival time, NIHSS before treatment, and NIHSS on day 3 of treatment in the control group was higher than that of the treatment group; the difference was statistically significant (P
Mehrdad Payandeh, Noorodin Karami, Soode Enayati, Afshin Karami, Mehrnoush Aeinfar, Fatemeh Yari
Published: 29 September 2018
Biomedical Research and Therapy, Volume 5, pp 2703-2707; doi:10.15419/bmrat.v5i9.482

Abstract:Multiple myeloma is described by the proliferation of malignant plasma cells, in which orbital involvement is rare. In this report, we collected all cases with orbital multiple myeloma from 2009 to 2018 and investigated the characteristics such as sex, age, common orbital symptoms, unilateral or bilateral and different therapeutic options. Also, we reported an uncommon case of multiple myeloma that has been developed into plasmacytoma. Our patient had been initially diagnosed with multiple myeloma, but after a few months, the disease had progressed to secondary extramedullary plasmacytoma in the retrobulbar. Therapeutic measures, such as surgery to prevent its development in the patient's eye, were successful.
Si Dung Chu, Khanh Quoc Pham, Dong Van Tran
Published: 29 September 2018
Biomedical Research and Therapy, Volume 5, pp 2680-2687; doi:10.15419/bmrat.v5i9.479

Abstract:Objectives: This study was designed to characterize the surface electrocardiogram (ECG) of the typical Wolff-Parkinson-White (WPW) syndrome to develop a new algorithm ECG to localize the septal accessory pathways (APs) and to prospectively test the accuracy of the algorithm. Methods: We studied 106 patients, in which 65 patients with typical WPW syndrome who had a single antero-grade with the localization of APs identified by successful radiofrequency catheter ablation (RFCA) to develop a new ECG algorithm for the septal AP localization. Then, this algorithm was tested prospectively in 41 patients to compare to the localization of APs by successful ablation by RFCA (gold standard). Results: In 65 patients with typical WPW syndrome, we found that the 12-lead ECG parameters such as the transition of the QRS complex, delta wave polarity in V1 lead, delta wave polarity in at least 2/3 inferior leads and QRS pattern'' in inferior leads can predict the localization of septal APs with the accuracy ranging from 83.3% to 100%. Then, 41 patients were prospectively evaluated by the new derived algorithm to localize the septal APs with high sensitivity and specificity from 84.6% to 100%. Conclusion: 12-lead ECG parameters in typical WPW syndrome are strongly correlated to the septal AP localization, which can be used to develop a new ECG algorithm to localize septal APs with high accuracy.
Published: 29 September 2018
Biomedical Research and Therapy, Volume 5, pp 2688-2696; doi:10.15419/bmrat.v5i9.480

Abstract:Objective: Genetics is a known factor in the susceptibility to cardiovascular disease. In this study, polymorphisms of endothelial nitric oxide synthase (eNOS) (T876C and G894T) and hypoxiainducible factor 1 (HIF1) (rs10873142 and rs41508050) in coronary artery disease were compared with healthy subjects, and the relationship between these mutations and risk of coronary artery disease (CAD) was assessed. Methods: Blood samples were collected from 138 patients with obstructive CAD and 115 healthy subjects. Polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP), Griess test, and enzyme-linked immunosorbent assay (ELISA) were used to measure serum nitric oxide (NO) and paraoxonase antioxidant. Independent t-test was used to examine the relationship between variables. Results: There was no significant difference between genotype frequency in healthy subjects and patients for eNOS and HIF1 alpha polymorphisms. There was no significant difference between these polymorphisms and age, sex, hypertension and lipidemia. Furthermore, the difference in mean serum levels of NO in different genotypes of the G894T gene was not significant between the patient and control groups. However, the difference in mean serum NO levels in different genotypes of the T786C gene was significant between the patient and control groups such that minimum and maximum serum NO levels were observed in individuals bearing TT and TC genotypes, respectively. The difference in mean serum NO levels was higher in patients than in controls, and was statistically significant. Conclusions: The results suggest that the T876C polymorphism could be associated with low serum NO level and implicated as a risk factor for developing CAD. Furthermore, our findings indicate that genetics may not be involved in susceptibility to CAD; however, further comprehensive studies are required.
Hossein Ali Safakhah, Farzaneh Tamimi, Nasroallah Moradi Kor, Ahmad Reza Bandegi, Ali Ghanbari
Published: 28 September 2018
Biomedical Research and Therapy, Volume 5, pp 2671-2679; doi:10.15419/bmrat.v5i9.477

Abstract:Background: It has been revealed that herbal medicines have a palliative effect on pain. In the present study, the hypoalgesic effect of Spirulina platensis (microalgae) on the neuropathic pain induced by chronic constriction injury (CCI) was investigated. Methods: In the present study, 74 adult male Wistar rats weighing 200-220 grams were used. For inducing neuropathic pain, CCI was performed on the left sciatic nerve. Spirulina platensis was intragastrically administered daily for 3 weeks. Mechanical allodynia and thermal hyperalgesia were assessed by Von Frey hairs and plantar test device, respectively. Malondialdehyde (MDA) and total antioxidant capacity (TOC) were detected in the serum using thiobarbituric acid and ferric reducing ability of plasma (FRAP), respectively. Results: CCI of the sciatic nerve led to mechanical allodynia and thermal hyperalgesia at three weeks as well as two weeks post surgery. Three weeks of Spirulina therapy significantly (P
Published: 28 September 2018
Biomedical Research and Therapy, Volume 5, pp 2664-2670; doi:10.15419/bmrat.v5i9.476

Abstract:Introduction: Stress-induced hyperglycemia (SIH) is commonly observed in critically ill patients and associated with poor clinical outcome for patients. Fenugreek seed powder has long been known as an anti-diabetic drug since its pharmaceutical properties were demonstrated. Materials: The study herein was a parallel, randomized controlled clinical trial consisting of 60 adult patients randomly divided into 2 groups (n=30 per group). The study was conducted in Sabzevar, Iran in April 2015. The intervention group received 3 g of fenugreek seed powder by gavage, twice a day, in addition to routine care. The control group received only routine care. In the beginning, a daily evaluation of fasting and postprandial blood sugar was conducted for 10 days. Secondary components (prevalence of pneumonia; length of intensive care unit (ICU) stay, length of hospital stay, ventilator days, APACHE II score, and mortality rate) were measured until the time of hospital discharge or death. Data were analyzed via SPSS v.20 using Student's t-test (paired and unpaired), chi-square test, repeated measure ANOVA, and Wilcoxon test. Results: In during 10 days of treatment, there was a significant fall in mean glucose levels in 2 groups. However, this improve was more significant in Intervention group in compared to control group (p
Vahid Amiri, Mohamadhossein Mohammadi, Mohammad Reza Khosravi Farsani, Arshia Gharehbaghian, Abbas Hajifathali, Zaher Khazaei, Mehdi Allahbakhshian Farsani
Published: 27 September 2018
Biomedical Research and Therapy, Volume 5, pp 2658-2663; doi:10.15419/bmrat.v5i9.475

Abstract:Introduction: Gene mutation is an infrequent cause of tumor suppressor gene (TSG) defect in de novo AML patients. Instead, it seems that leukemic cells employ epigenetic tricks to attenuate the negative impacts of intact TSGs. Ordinarily, critical TSGs, such as p16INK4A, is hyper-methylated in AML blasts under the impact of master epigenetic regulators, such as UHRF1. In this study, we investigated the correlation between UHRF1 and p16INK4A gene expression levels in newly diagnosed AML patients. Methods: Bone marrow and peripheral blood samples were obtained from 50 newly diagnosed AML patients and 18 healthy normal control subjects. Gene expression levels of UHRF1 and P16INK4A were surveyed using SYBR Green Quantitative Real-time PCR. Statistical analyses were done using SPSS statistical software 21.0. Results: P16INK4A gene expression showed reduced levels in 80.64% of patients above 45 years of age, while only 32% of patients below 45 years had reduced expression levels. The Spearman correlation test also demonstrated a significant negative correlation between UHRF1 and p16INK4A gene expression levels in AML patients, which was not observed in the control group (r=0.343 and P= 0.015). Conclusion: Regarding the age-related patterns of UHRF1 and p16INK4A gene expression, and also the presence of negative correlation between them, we conclude that UHRF1 may potentially be involved in p16INK4A down-regulation in elderly AML patients, which may subsequently facilitate the progression of AML in older ages.
Titilope M. Dokunmu, Grace I. Olasehinde, David O. Oladejo, Cynthia U. Adjekukor, Adesola E. Akinbohun, Olabode A. Onileere, Chisom J. Eze, Grace S. Jir
Published: 24 September 2018
Biomedical Research and Therapy, Volume 5, pp 2651-2657; doi:10.15419/bmrat.v5i9.474

Abstract:Introduction: Plasmodium falciparum has developed resistance to artemisinin drugs in Southeast Asia, and its reduced sensitivity has been reported in other regions. This study aims to determine parasite susceptibility to the bioactive form of artemisinin derivatives- dihydroartemisinin (DHA)-, and to detect the K13 polymorphism in isolates from an endemic area of Nigeria. Methods: Ex-vivo response in 55 parasites isolates obtained from malaria-positive patients were exposed to pulse DHA concentration and cultured for 66 hours ex-vivo. Parasite ring stage survival (RSAex-vivo) relative to unexposed matched control was determined by microscopy, and parasite growth was compared using Mann-Whitney U-test at a significance level of P
Published: 21 September 2018
Biomedical Research and Therapy, Volume 5, pp 2645-2645; doi:10.15419/bmrat.v5i9.472

Abstract:Dear Sir, From the beginning of life on this planet research and writing remained one of the most important aspect for getting more attentions and values. But, with the pas- sage of times different methods has been introduced to share the knowledge and information i.e. from hand writing to hard publication and then to online publication. Dear readers, it was a story of 2015 when the honorable Dr. Phuc Van Pham (Founder and Editor-in-Chief) came with an idea and started the journal with name Biomedical Research and Therapy is the official journal of the Laboratory of Stem Cell Research and Application (SCL) (now as Stem Cell Institute, VNUHCM University of Science, Ho Chi Minh city, Viet Nam). After launching the journal, it was thinking that the journal will not exist for long time, be- cause it was a hard journey with limited resources. However, the journal is entered in to their 5th volume in 2018. Due to the hard working, creative ideas, team working and non-stoppable efforts of Dr. Pham and his team proofed that Biomedical Research and Therapy is one the emerging journal in the field of biomedical sciences. The journal is now indexed and abstracted by world renowned databases including Web of Science, Scopus, Embase, Index Copernicus, Ebsco, and Google Scholar. In a very short time of period the journal become more popular in the Asian countries. Researchers from different parts of the world is publishing their work in Biomedical Research and Therapy. On the behalf of Editor-in-Chief and Editorial Office of Biomedical Research and Therapy I am thankful and extended my gratitude to every single person who contributed for this journal. We also acknowledge the support of Springer International Publisher. I do hope that all of you will continue your valuable and non-stoppable support for Biomedical Research and Therapy. Tauseef Ahmad Associate Editor, Biomedical Research and Therapy
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