Journal International Journal of Applied Pharmaceutical Sciences and Research

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33 articles
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Pushpa Yadav, Mangla Nand Singh, Shubhini A. Saraf, Neha Katiyar
International Journal of Applied Pharmaceutical Sciences and Research, Volume 3; doi:10.21477/ijapsr.v3i01.10421

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Swetha U.
International Journal of Applied Pharmaceutical Sciences and Research, Volume 2; doi:10.21477/ijapsr.v2i04.9904

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V. Sandhya, K. Sunand, A. Swapna, K. Prasanth, A. Vijaya, J. Geetha
International Journal of Applied Pharmaceutical Sciences and Research, Volume 2; doi:10.21477/ijapsr.v2i04.9603

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Tribhuvan Singh, Syed Imran Ul Haq, Shaik Mohammed Salman, Afifa Namreen, Anas Rasheed
International Journal of Applied Pharmaceutical Sciences and Research, Volume 2; doi:10.21477/ijapsr.v2i04.9552

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Anusha Shivaraj, Shireesha Battula
International Journal of Applied Pharmaceutical Sciences and Research, Volume 2; doi:10.21477/ijapsr.v2i03.8253

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Anas Rasheed, Osman Ahmed
International Journal of Applied Pharmaceutical Sciences and Research, Volume 2; doi:10.21477/ijapsr.v2i03.8252

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Anas Rasheed, Osman Ahmed
International Journal of Applied Pharmaceutical Sciences and Research, Volume 2; doi:10.21477/ijapsr.v2i03.8254

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Shireesha Battula, Anusha Shivaraj
International Journal of Applied Pharmaceutical Sciences and Research, Volume 2; doi:10.21477/ijapsr.v2i03.8255

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Anas Rasheed, Osman Ahmed
International Journal of Applied Pharmaceutical Sciences and Research, Volume 2; doi:10.21477/ijapsr.v2i3.8101

Abstract:A short selective, precise, accurate and sensitive stability-indicating gradient LC-MS/MSn method was developed for the quantitative determination of process-related impurities and degradation products of Ipratropium bromide in pharmaceutical respules formulations. During the stress study, the degradation products of Ipratropium bromide were well-resolved from Ipratropium bromide and its impurities and the mass balances were found to be satisfactory in all the stress conditions, thus proving the stability-indicating capability of the method. The developed method was validated as per ICH guidelines with respect to specificity, linearity, limit of detection and quantification, accuracy, precision, ruggedness, and robustness. During the stability analysis of the drug product, one unknown impurity was detected by the above stability-indicating method. The flow rate was 0.5 ml/min and effluent was monitored at 242nm. Retention time was found to be 5.015±0.15 min. The LOD and LOQ values for were found to be 0.20996 (μg/ml) and 0.63624 (μg/ml) respectively.
Sai Lakshmi E., Sravya. E, Sireesha. D, Vasudha Bakshi
International Journal of Applied Pharmaceutical Sciences and Research, Volume 2; doi:10.21477/ijapsr.v2i3.8099

Abstract:A new simple, rapid, specific, accurate, precise and novel Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method has been developed for the estimation of Sitagliptin Phosphate in the pharmaceutical dosage form. The chromatographic separation for Sitagliptin was achieved with mobile phase containing methanol, Thermoscientific C18 column, (250x4.6 particle size of 5μ) at room temperature and UV detection at 248 nm. The compounds were eluted in the isocratic mode at a flow rate of 1ml/min. The retention time of Sitagliptin was 1.91min. The above method was validated in terms of linearity, accuracy, precision, LOD and LOQ in accordance with ICH guidelines.
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