BAOJ Pharmaceutical Sciences

Journal Information
EISSN : 23805552
Current Publisher: Bio Accent Group LLC (10.24947)
Total articles ≅ 28
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Latest articles in this journal

BAOJ Pharmaceutical Sciences; doi:10.24947/2380-5552

Osman N
Published: 20 December 2016
BAOJ Pharmaceutical Sciences, Volume 2, pp 1-5; doi:10.24947/2380-5552/2/3/128

Nachiket Dighe
BAOJ Pharmaceutical Sciences, Volume 2, pp 1-8; doi:10.24947/2380-5552/2/3/127

Mohammed Ali
Published: 11 November 2016
BAOJ Pharmaceutical Sciences, Volume 2, pp 1-6; doi:10.24947/2380-5552/2/3/126

Uyen Le
BAOJ Pharmaceutical Sciences, Volume 2, pp 1-5; doi:10.24947/2380-5552/2/2/125

Xincai Hao
Published: 8 September 2016
BAOJ Pharmaceutical Sciences, Volume 2, pp 1-4; doi:10.24947/2380-5552/2/2/123

Jan Fourman
BAOJ Pharmaceutical Sciences, Volume 2, pp 1-5; doi:10.24947/2380-5552/2/2/122

Joseph Smith
BAOJ Pharmaceutical Sciences, Volume 2, pp 1-2; doi:10.24947/2380-5552/2/2/121

Minlu Hu, Tian Zhou, Andrew P Pearlman, Dorothy L Paton, Lisa C Rohan
Published: 3 May 2016
BAOJ Pharmaceutical Sciences, Volume 2

Abstract:This manuscript summarizes our recent progress in examine the CYP1A1 and CYP1B1 as well as a number of nuclear receptors in the female genital and colorectal tissues of human and pigtailed macaque. Understanding the nuclear receptor mediated regulation of CYP1A1 and 1B1 expression in these tissues is necessary for identifying cancer risk factors and developing CYP1A1/1B1-targeted anti-cancer therapeutics. However, there is a lack of systematic and comparative analysis of the expression profile of CYP1A1, 1B1 and NRs in the female genital and colorectal tissues of human and clinically relevant animal models. The current study aims to fill this gap. We found CYP1A1, CYP1B1 and a number of nuclear receptors were expressed in the female genital and colorectal tissues of human and macaque. However, the mRNA level and protein localization of these CYP enzymes and NRs depended on the type of tissue examined.