BAOJ Pharmaceutical Sciences
Journal Information
EISSN :
23805552
Current Publisher: Bio Accent Group LLC (10.24947)
Total articles ≅ 28
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BAOJ Pharmaceutical Sciences; doi:10.24947/2380-5552
BAOJ Pharmaceutical Sciences, Volume 2, pp 1-5; doi:10.24947/2380-5552/2/3/128
BAOJ Pharmaceutical Sciences, Volume 2, pp 1-8; doi:10.24947/2380-5552/2/3/127
BAOJ Pharmaceutical Sciences, Volume 2, pp 1-6; doi:10.24947/2380-5552/2/3/126
BAOJ Pharmaceutical Sciences, Volume 2, pp 1-5; doi:10.24947/2380-5552/2/2/125
BAOJ Pharmaceutical Sciences, Volume 2, pp 1-6; doi:10.24947/2380-5552/2/2/124
BAOJ Pharmaceutical Sciences, Volume 2, pp 1-4; doi:10.24947/2380-5552/2/2/123
BAOJ Pharmaceutical Sciences, Volume 2, pp 1-5; doi:10.24947/2380-5552/2/2/122
BAOJ Pharmaceutical Sciences, Volume 2, pp 1-2; doi:10.24947/2380-5552/2/2/121
Published: 3 May 2016
BAOJ Pharmaceutical Sciences, Volume 2
Abstract:This manuscript summarizes our recent progress in examine the CYP1A1 and CYP1B1 as well as a number of nuclear receptors in the female genital and colorectal tissues of human and pigtailed macaque. Understanding the nuclear receptor mediated regulation of CYP1A1 and 1B1 expression in these tissues is necessary for identifying cancer risk factors and developing CYP1A1/1B1-targeted anti-cancer therapeutics. However, there is a lack of systematic and comparative analysis of the expression profile of CYP1A1, 1B1 and NRs in the female genital and colorectal tissues of human and clinically relevant animal models. The current study aims to fill this gap. We found CYP1A1, CYP1B1 and a number of nuclear receptors were expressed in the female genital and colorectal tissues of human and macaque. However, the mRNA level and protein localization of these CYP enzymes and NRs depended on the type of tissue examined.