AAPS PharmSciTech

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ISSN / EISSN : 1530-9932 / 1530-9932
Published by: Springer Nature (10.1208)
Total articles ≅ 3,772
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, Vladimir Villanueva-Lopez, Shashank Venkat Muddu, Gregory D. Doddridge, Dana Alhasson, Michael C. Dennis
Published: 14 October 2021
AAPS PharmSciTech, Volume 22, pp 1-12; https://doi.org/10.1208/s12249-021-02148-x

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Sara Fathollahi, Julia Kruisz, Stephan Sacher, Jakob Rehrl, M. Sebastian Escotet-Espinoza, James DiNunzio, Benjamin J. Glasser,
Published: 12 October 2021
AAPS PharmSciTech, Volume 22, pp 1-14; https://doi.org/10.1208/s12249-021-02104-9

Abstract:
This paper proposes a feed rate control strategy for a novel volumetric micro-feeder, which can accomplish low-dose feeding of pharmaceutical raw materials with significantly different powder properties. The developed feed-forward control strategy enables a constant feed rate with a minimum deviation from the set-point, even for materials that are typically difficult to accurately feed (e.g., due to high cohesion or low density) using conventional continuous feeders. Density variations observed during the feeding process were characterized via a displacement feed factor profile for each powder. The characterized effective displacement density profile was applied in the micro-feeder system to proactively control the feed rate by manipulating the powder displacement rate (i.e., computing the feed rate from the powder displacement rate). Based on the displacement feed factor profile, the feed rate can be predicted during the feeding process and at any feed rate set-point. Three pharmaceutically relevant materials were used for the micro-feeder evaluation: di-calcium phosphate (large-particle system, high density), croscarmellose sodium (small-particle system, medium density), and barium sulfate (very small-particle <10 μm, high density). A significant improvement in the feeding performance was achieved for all investigated materials. The feed rate deviation from the set-point and its relative standard deviation were minimal compared to operations without the control strategy.
Manal A. Elsheikh, Samar A. Rizk, , Ossama Y. Abdallah
Published: 6 October 2021
AAPS PharmSciTech, Volume 22, pp 1-12; https://doi.org/10.1208/s12249-021-02112-9

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, Pan Gao, Zhujun Jiang, Qiao Luo, Chengqiao Mu, Mengsuo Cui
Published: 5 October 2021
AAPS PharmSciTech, Volume 22, pp 1-12; https://doi.org/10.1208/s12249-021-02085-9

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Rahil Dalal, , Bapi Gorain, Hira Choudhury, Shery Jacob, Tejal A. Mehta, Hiral Shah, Anroop B. Nair
Published: 4 October 2021
AAPS PharmSciTech, Volume 22, pp 1-20; https://doi.org/10.1208/s12249-021-02132-5

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Mumuni Sumaila, Thashree Marimuthu, Pradeep Kumar,
Published: 30 September 2021
AAPS PharmSciTech, Volume 22, pp 1-25; https://doi.org/10.1208/s12249-021-02124-5

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Gayathri Ramachandran,
Published: 30 September 2021
AAPS PharmSciTech, Volume 22, pp 1-15; https://doi.org/10.1208/s12249-021-02125-4

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, Suthep Saengsod, Sontaya Limmatvapirat
Published: 29 September 2021
AAPS PharmSciTech, Volume 22, pp 1-9; https://doi.org/10.1208/s12249-021-02127-2

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Kai-Wei Wu, Corinne Sweeney, Narendar Dudhipala, Prit Lakhani, Narayan D. Chaurasiya, Babu L. Tekwani,
Published: 29 September 2021
AAPS PharmSciTech, Volume 22, pp 1-12; https://doi.org/10.1208/s12249-021-02108-5

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