Seminars in Cancer Biology

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ISSN / EISSN : 1044-579X / 1096-3650
Current Publisher: Elsevier BV (10.1016)
Former Publisher:
Total articles ≅ 2,080
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Latest articles in this journal

, S. Raj J. Trikha, Henry J. Thompson
Published: 1 May 2021
Seminars in Cancer Biology, Volume 70, pp 53-60; doi:10.1016/j.semcancer.2020.06.007

The publisher has not yet granted permission to display this abstract.
Var Ruchi Sharma, Manoj Singh, Vikas Kumar, Mukesh Yadav, Nirmala Sehrawat, Daljit K. Sharma,
Published: 1 May 2021
Seminars in Cancer Biology, Volume 70, pp 61-70; doi:10.1016/j.semcancer.2020.07.006

The publisher has not yet granted permission to display this abstract.
Jatin Chadha, Deeptashree Nandi, Yama Atri,
Published: 1 May 2021
Seminars in Cancer Biology, Volume 70, pp 112-127; doi:10.1016/j.semcancer.2020.07.010

The publisher has not yet granted permission to display this abstract.
Published: 1 May 2021
Seminars in Cancer Biology, Volume 70; doi:10.1016/s1044-579x(21)00046-8

Huifang Si, Qing Yang, Hong Hu, Chunsheng Ding, Huichao Wang,
Published: 1 May 2021
Seminars in Cancer Biology, Volume 70, pp 3-10; doi:10.1016/j.semcancer.2020.05.004

Abstract:
Colorectal cancer (CRC) is the most common cancer in the world, and its incidence has been increasing in recent years. The occurrence of CRC is believed to be related to a variety of factors. Epidemiological data indicate that CRC is mainly affected by environmental factors, eating habits, physical activity and genetic factors. As a newly recognized functional component, the intestinal microbiota plays important roles in preventing CRC formation and maintaining intestinal immunity. In this review, we summarize the mechanisms by which the gut microbiota causes CRC through alterations to immune function, focusing on the mechanisms by which intestinal microbial dysfunction promotes CRC. Furthermore, we describe the changes in the intestinal flora observed in CRC and their potential for CRC treatment with the goal of facilitating future research on the roles of the intestinal flora.
Raghwendra Pratap Singh, Hilal Bashir,
Published: 1 May 2021
Seminars in Cancer Biology, Volume 70, pp 37-52; doi:10.1016/j.semcancer.2020.06.008

The publisher has not yet granted permission to display this abstract.
Published: 1 May 2021
Seminars in Cancer Biology, Volume 70, pp 11-23; doi:10.1016/j.semcancer.2020.06.006

Abstract:
The microbiota influences human health and the development of diverse diseases, including cancer. Microbes can influence tumor initiation and development in either a positive or negative manner. In addition, the composition of the gut microbiota affects the efficacy and toxicity of cancer therapeutics as well as therapeutic resistance. The striking impact of microbiota on oncogenesis and cancer therapy provides compelling evidence to support the notion that manipulating microbial networks represents a promising strategy for treating and preventing cancer. Specific microbes or the microbial ecosystem can be modified via a multiplicity of processes, and therapeutic methods and approaches have been evolving. Microbial manipulation can be applied as an adjunct to traditional cancer therapies such as chemotherapy and immunotherapy. Furthermore, this approach displays great promise as a stand-alone therapy following the failure of standard therapy. Moreover, such strategies may also benefit patients by avoiding the emergence of toxic side effects that result in treatment discontinuation. A better understanding of the host–microbial ecosystem in patients with cancer, together with the development of methodologies for manipulating the microbiome, will help expand the frontiers of precision cancer therapeutics, thereby improving patient care. This review discusses the roles of the microbiota in oncogenesis and cancer therapy, with a focus on efforts to harness the microbiota to fight cancer.
Published: 1 May 2021
Seminars in Cancer Biology, Volume 70, pp 134-138; doi:10.1016/j.semcancer.2020.06.011

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Published: 1 May 2021
Seminars in Cancer Biology, Volume 70, pp 85-97; doi:10.1016/j.semcancer.2020.06.017

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