EUREKA: Health Sciences

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ISSN / EISSN : 2504-5660 / 2504-5679
Current Publisher: OU Scientific Route (10.21303)
Total articles ≅ 299
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Iryna Kazakova, Viacheslav Lebedynets, , Viktoriya Kazakova
Published: 31 March 2021
EUREKA: Health Sciences pp 44-55; doi:10.21303/2504-5679.2021.001700

Abstract:
The perfumery and cosmetic industry of Ukraine is distinguished by its dynamic development and makes a significant contribution to the country's economy. Several types of economic activities are involved in its functioning, including the development, research, production and sale of perfumery and cosmetic products, as well as the provision of cosmetic services to the population. The economic activity of each sector in the chain of creation, production and sale of cosmetic products / services determines both their individual success and the efficiency of the entire system as a whole. In this regard, the systematization and analysis of the indicators of economic activity of enterprises of each type of activity of the national cosmetic industry is an urgent task, the solution of which will reasonably determine the prospects for both the further development of this industry and the export potential of the Ukrainian economy as a whole. The aim of this work was to conduct a comprehensive study of the dynamics of the main indicators of Ukrainian enterprises of perfumery, cosmetic and related industries economic activity for the period 2010–2019 and determination of their development trends. The available data of the State Statistics Service of Ukraine, the Patent Office of Ukraine, as well as a database of scientific and professional publications publications were used as materials and methods. Retrospective, logical, research methods, as well as the method of content analysis were used. The results of a comparative analysis of the main indicators of the economic activity of business entities in the studied industry made it possible to establish trends in the development of this sector of the economy and substantiate the patterns observed at the present stage. Conclusions. The results of the study indicate that the production potential of the perfumery and cosmetic industry in Ukraine is promising, as well as significant opportunities for further development of the trade in these products and the provision of cosmetic services to the population.
Hryhorii Zon, Lyudmyla Ivanovska, Illia Zon, Tion Matthew Terzungwe
Published: 31 March 2021
EUREKA: Health Sciences pp 102-110; doi:10.21303/2504-5679.2021.001690

Abstract:
Aim of the study: to examine the pathological changes in dogs that died due to confirmed intestinal yersiniosis and parvoviral enteritis and establish trends for characteristic organ lesions for both diseases in comparison, then evaluate our findings with the existing published material of sufficient evidence quality regarding differential postmortem diagnosis of spontaneous intestinal yersiniosis and parvoviral enteritis in dogs. Materials and methods: the study examined the cases of 25 dogs from 2 month to 1.3 y.o. of various breed, gender that died due to either confirmed Canine parvoviral enteritis (CPV) infection or intestinal yersiniosis and subsequently divided into two groups based on their diagnosis. The definitive diagnosis has been confirmed by performing rapid ELISA diagnostics (SensPERT®, VetAll Laboratories, Kyunggi-Do, Korea) for CPV and serological tests for Y. enterocolitica sera AT were performed using yersiniosis antigens from the "Component set for serological diagnosis of animal yersiniosis" (Kharkiv, NSC IEKVM, TS 46.15.091-95) in accordance with the "Interim guidelines for the use of a set of components for serological diagnostics". A dilution of 1: 200 has been considered as the diagnostic titer. After the definitive diagnosis had been confirmed, the animals were divided into two groups, depending on diagnosis: CPV (n=14) or IY (n=11). The autopsies of twenty randomly (10 from each group) selected dog corpses have been conducted utilizing standard methodology. Results: according to the results of autopsy of dogs afflicted by CPV, the main pathological changes were found in the small intestine – catarrhal-desquamative inflammation (in 100 % of cases), serous-hemorrhagic mesenteric lymphadenitis (90 %) large intestine (70 %) in the stomach (60 %), in the liver (50 %), in other organs – less than 40 percent of cases and most notably caused lung damage (edema and local atelectasis) in 90 % of the animals in the study, which was not the case for intestinal yersiniosis with only 20 % incidence of lung damage. Conclusions: Spontaneous intestinal yersiniosis in dogs was pathologically manifested by pronounced catarrhal-desquamative processes mainly in the stomach and small intestine (70, 100 and 80 % of cases, respectively), inflammation of the mesenteric lymph nodes (90 %) and large intestine (80 %), dystrophy and congestive processes in the liver (80 %). Low incidence and type of lung damage (congestive hyperemia in 20 % of reviewed cases compared to 90 % of local atelectasis add edema in CPV group) was noteworthy. Cases of 25 animals that died due to either confirmed CPV or Y. enterocolitica infection were analyzed, and 20 animal corpses were autopsied during study. Dogs that died from intestinal yersiniosis had significantly higher frequency of pathological findings in kidney (200 %) and liver (60 %) in particular. Changes in stomach and large intestine were also more frequent. At the same time, we observed a lower frequency of pathological changes in spleen (33 % lower), heart (25 % lower) and the lowest frequency was in lungs (77 % lower) presented by edema and local atelectasis in animals afflicted by yersiniosis compared to CPV. Incidence and manifestation of pathological findings was mesenteric lymph nodes and abdominal cavity were similar, and could not be considered during posthumous diagnostics.
Kostyantyn Balashov, Olesya Hulchiy, Gennady Slabkiy
Published: 31 March 2021
EUREKA: Health Sciences pp 16-23; doi:10.21303/2504-5679.2021.001709

Abstract:
The aim. To study the factors of doctors’ assessment of their lifestyle as a healthy one, as well as their readiness to take practical measures for health maintenance. Materials and methods. 167 doctors representing all macro regions of Ukraine were interviewed: the levels of awareness of myths about NCDs, locus of control and readiness to take practical measures aimed at health maintenance were determined. The main acting forces were determined by factor analysis. Cluster analysis was performed on the basis of the obtained factors using hierarchical (Ward’s method) and non-hierarchical (k-means method) clustering methods. Results. The following concepts were assessed: Myths about NCDs (11 factors, 3 elements, 4 clusters), locus of control (12 factors, 3 elements, 4 clusters), factors influencing health behavior (12 factors, 3 elements, 4 clusters), readiness to take practical measures aimed at health maintenance (22 factors, 4 elements, 2 clusters). Factors that positively and negatively affect a person's assessment of the lifestyle as a healthy one were identified. Conclusions. The selected subgroups (clusters) of respondents are a simple and effective method of building a better understanding of the target audience of campaigns to promote healthy lifestyles, which after proper clarification, verification and development of a reliable measurement tool can be used to create targeted messages for each population group after a proper clarification and verification
Ievgenii Gladukh, Maiia Podorozhna
Published: 31 March 2021
EUREKA: Health Sciences pp 82-89; doi:10.21303/2504-5679.2021.001732

Abstract:
Rheological parameters are an important characteristic of semisolid dosage forms. Structural and mechanical characteristics have a noticeable effect on the processes of release and absorption of drugs from ointments, as well as on their consumer properties: spreadability, adhesion, the ability to squeeze out of the tubes. The aim: to study the rheological parameters of aqueous solutions of sodium alginate in various concentrations to create medicinal hydrogel compositions. Materials and methods: sodium alginate (Shandong Topsea Seaweed Industrial Co., Ltd., China) was used as a gelling agent. The physicochemical properties of the samples were studied according to generally accepted methods of the State Pharmacopoeia of Ukraine. Rheological studies of experimental samples were carried out using a rotational viscometer «Rheolab QC», by Anton Paar (Austria) with coaxial cylinders C-CC27/SS at a temperature 20–25 °С. Results and discussion: the rheological profiles of sodium alginate gels have a non-Newtonian type of flow, which makes it possible to characterize them as systems with plastic-viscous properties. Gels with a sodium alginate concentration of 1.5–2 % have the best indicators of yield stress, hysteresis loop area, mechanical stability and dynamic flow coefficients. This indicates a low degree of destruction of the structural grid in the process of mechanical action and the presence of thixotropic bonds. Conclusions: sodium alginate gel base at 0.5 % and 1 % concentration is less stable under stress compared to sodium alginate bases at 1.5 % and 2 % concentration. The gel base of sodium alginate at a concentration of 2 % has the optimal mechanical stability value.
Zhanna Klishchova,
Published: 31 March 2021
EUREKA: Health Sciences pp 97-101; doi:10.21303/2504-5679.2021.001688

Abstract:
Salmonellosis is an acute intestinal infectious disease that belongs to the group of zoonoses that cause acute toxic infections in humans through the consumption of products of animal or plant origin contaminated with bacteria of the genus Salmonella spp. Salmonellosis is registered in all countries of the world, and our state is no exception. The aim of the research. Monitor salmonellosis pathogens in Ukrainian poultry farms and, on the basis of the obtained data, establish the relationship between avian and human diseases for salmonellosis. Materials and methods. The research was conducted in poultry farms in the North-Eastern region of Ukraine. Test systems from R-biopharm-Compact Dry SL and RIDA®STAMP SL were used for rapid diagnosis of bacterial microflora. To establish the salmonella serotype, the Spectate® salmonella test system was used, which is based on the use of latex strips coated with special antibodies to the corresponding serogroups of Salmonella A, B, C, D. Microbiological examination was performed washing from the walls, floor, eggshell, Brooder's cabinets and pathogens heart, liver, gallbladder of the dead bird. The relationship between isolated salmonella serovars from poultry was compared with salmonella isolated from humans according to the reporting form No. 40 “Zdorov”. Results. Various salmonella serovars were isolated from experimental farms of Ukraine, namely: Serovars such as S. Gallinarum–pullorum – 7.9 %, S. Enteritidis – 6.5 % were isolated from the meat and egg direction. From the meat direction, the following are: S. Tiphimurium – 12.5 %, S. Arizona – 6.0 %, S. Enteritidis – 3.5 %. From the breeding direction were also isolated from adult birds and hatching eggs in large quantities – S. Gallinarum–pullorum – 19.0 %, S. Tiphimurium – 17.8 %, S. Enteritidis – 10.1 %. The following species were separately isolated from the premises of the same farms in percentage terms: S. London – 1.7 %, S. Infantis – 1.5 % S. Bredeney – 1.4 %, S. Tsioque – 1.4 %, S Jawa – 1.2 %, S. Montevideo – 1.1 %, and 1 % each isolated S. Kentyki, S. Abony and S. Oxford. Pathogens of paratyphoid diseases were isolated from poultry and poultry products (S. Gallinarum–pullorum, S. Enteritidis, S. Tiphimurium) for the entire study period from 2016 to 2020 inclusive. Comparing the obtained data from state institutions of humane medicine, it should be noted that there was a tendency for the spread of salmonellosis among people associated with the consumption of poultry products. Conclusions. The obtained results indicate that salmonella infection is quite common among a number of poultry farms of different technological direction. In particular, bacteria of the genus Salmonella were isolated from meat, eggs and birds of different ages from the studied poultry houses in the North-Eastern region of Ukraine. As a result of monitoring of salmonellosis in Ukraine over the past five years, fluctuations in the incidence of salmonellosis among people ranged from a maximum of 74 % (2018) to a minimum of 30.1 % (2020), and for two years, there has been a reduction in cases due to the introduction of new international requirements and standards for product quality control at all stages of production of the Hazard Analysis and Critical Control Point (HACCP) system.
Dmytro Kisil, Tetiana Fotina,
Published: 31 March 2021
EUREKA: Health Sciences pp 90-96; doi:10.21303/2504-5679.2021.001711

Abstract:
The aim of the study was to determine the effectiveness of the drug "Cobazin" on the productivity of bee colonies during the increase in strength (increase in the number of young bees in the bee colony) in spring and autumn. Materials and methods. Control and experimental groups were formed to test "Cobazin" feed supplement. It was fed 5 times with an interval of 5 days. Bee colonies from the control group received a pure sugar solution (1:1) in the amount of 0.5 liters per bee colony, and the experimental group received a sugar solution of 0.5 liters per bee colony (1:1) with the addition of the drug "Cobazin" in the amount of 2.5 g. Indicators characterizing the development of bee colonies were determined by a measuring frame of 5x5 cm in size, for 12 days to cover the total number of eggs laid by the queen bee during feeding. Four measurements were performed during the study. The results of the control and experimental groups were compared and the significance of the differences between them was established. There was a comparison of the difference between groups of bees both fed pure sugar syrup in a ratio of 1:1 and syrup with the addition of the drug "Cobazin". Results. It is proved that during the feeding period the number of brood in bee colonies that received feed supplement "Cobazin" increased significantly by 76 % (71 % in the group that received only sugar solution without this drug). Live weight of queen bees in colonies that were stimulated with "Cobazin" was actually 2 % higher compared to the control group. It was found that at the end of the bee season, bee colonies fed in May with the feed supplement "Cobazin" had significantly higher values of strength, number of sealed brood and live queen bees compared to those who received pure sugar solution. The brood in the control group was 25 % lower than in the experimental group. Conclusions. For the first time it was proved that the use of feed supplement "Cobazin" in combination with sugar solution has a positive effect on the features that characterize the development of bee colonies (strength, number of sealed brood) and their health productivity. The positive impact is observed not only during feeding, but also in subsequent periods of colony development.
Nikolay Shcherbina, Natalia Shelest
Published: 31 March 2021
EUREKA: Health Sciences pp 3-8; doi:10.21303/2504-5679.2021.001683

Abstract:
Underlying biochemical factors that contribute towards the preparedness for labour and ripening of the cervix remain largely unknown. We aimed to characterize metabolic and hormonal determinants that constitute the preparedness for labour in women. The aim of the research was to study the content of relaxin and amino acids involved in its formation in primiparous pregnant women with various degrees of birth preparedness. Materials and methods: Prospective study has been conducted on 115 primiparous women at 38-40 weeks of gestation. Biochemical methods were used to analyse relaxin and amino acid levels in pregnant women with varying degree of birth preparedness. Results: the obtained data from the study indicate importance role of relaxin in the underlying pathogenesis in women with variable degree of preparedness for labour. The results allow to use the levels of relaxin serum as a predictor of the state of the birth canal. Furthermore, the amino acids are known to participate in various critical metabolic processes and play an important role is orchestrating many essential pathways in the body. We present the analysis of amino acids involved in the formation of relaxin in the serum of pregnant women. Our analysis has shown that amino acid imbalance leads to disruption of energy metabolism and blood flow rate, resulting in metabolic, structural and functional changes in the cervix at the onset of labour. Conclusion: considering the mechanisms of the possible influence of relaxin and amino acids on the cervical ripening, we concluded that correcting amino acid imbalance and normalising relaxin levels should be included in preinduction of labour therapeutic regimen. This would be an important step in improving the perinatal outcomes
Olga Yasynovska
Published: 31 March 2021
EUREKA: Health Sciences pp 111-118; doi:10.21303/2504-5679.2021.001692

Abstract:
The aim of the research. To compare the ovicidal efficiency of insectoacaricides of different composition and manufacturers on flea eggs (Ctenocephalides spp.) for treatemnt of the premises where animals live. Materials and methods of the research. The study was conducted on the basis of the clinic of veterinary medicine "Vetservice" Sumy, laboratory "Veterinary Pharmacy" and "Innovative technologies and safety and quality of livestock products" of Sumy National Agrarian University. The ovicidal effect of insectoacaricides on flea eggs of Ctenocephalides spp. was studied. Ctenocephalides spp. eggs were selected from the pet bedding on which the animal spended most of its time, namely the cats. The studied material was selected with a cosmetic brush. Ctenocephalides spp. eggs were placed into a Petri dish of 10 eggs per each dish. The test material was introduced with a dental probe. There were 4 test dishes, which were treated with insectoacaricides (each test dish was treated with a separate drug) and 1 control dish with no treatment. Microscopy was conducted under a light microscope with magnification X8 of each egg, with following treatment of each egg with insectoacaricides. Monitoring was conducted in 24, 48 and 72 hours after treatment. Results. Research has shown that drugs which demonstrated 100 % ovicidal effectiveness were Sentry Home (pyriproxyfen – 0.02 %, permethrin – 0.2 %, n-Octyl Bicyclohepten – 1.0 %) in 24 hours and Neostomazan (CEVA)(transmix – 5.0 g, tetramethrin – 0.5 g) in 72 hours. Conclusions. Insectoacaricide drug Sentry Home (pyriproxyfen – 0.02 %, permethrin – 0.2 %, n-Octyl Bicyclohepten – 1.0 %), used for the treatment of the premises where the animals live, showed the most pronounced ovicidal effect in 24 hours.
Svitlana Chernetska, Natalia Beley, Mariana Demchuk
Published: 31 March 2021
EUREKA: Health Sciences pp 73-81; doi:10.21303/2504-5679.2021.001664

Abstract:
The aim. The aim of the research was to study the influence of excipients amount on the technological parameters of the compression mixture and tablets based on dry extract of Origanum vulgare L. herb using the method of random balance. Materials and methods. Objects of the study – Origanum vulgare L. herb dry extract, 8 excipients that have been studied at two quantitative levels. The tablets were prepared by direct compression method. The formulations were designed according to the method of random balance. The technological parameters of the compression mixture and tablets based on Origanum vulgare L. herb dry extract have been studied as a function of quantitative factors: silicon, magnesium carbonate basic, dioxide magnesium aluminometasilicate (Neusilin S1®), isomalt (GalenIQ™720), F-melt® Type C (co-spray dried excipients), sucralose, berry flavor and citric acid. Results and discussion. The increase in the amount of Neusilin S1®, GalenIQ™720 and F-melt®, and the decrease in the amount of magnesium carbonate basic and silicon dioxide improved the flowability expressed by the Hausner ratio. Results of bulk density and tapped density of the compression mixture depended on the quantities of GalenIQ™720 and F-melt®. All formulations of the prepared tablets had the rapid disintegration and ranging from 6 to 15 minutes. Resistance for crushing and friability tablets’ were improved with a decrease in the amount of silicon dioxide and increase in the amount of Neusilin S1®, F-melt® and sucralose. Higher resistance to moisture of tablets based on Origanum vulgare L. dry extract was obtained by using Neusilin S1®, F-melt® and sucralose on the upper levels. Conclusions. The tablets based on Origanum vulgare L. herb dry extract were successfully manufactured by direct compression method. The random balance method enabled us to identify the most significant quantitative factors to optimize their composition in the tablets based on the dry extract of Origanum vulgare L. herb.
Karyna Tolmachova, , , Svetlana Grashchenkova,
Published: 31 March 2021
EUREKA: Health Sciences pp 64-72; doi:10.21303/2504-5679.2021.001712

Abstract:
The aim of the experiment was to study the anti-inflammatory effect of the novogalene agent Ledum 50, obtained from Ledum palustre shoots, in a rat model of acute bronchitis. Materials and methods. Acute bronchitis was initiated by endotracheal administration of 1 % formalin solution. The effectiveness of Ledum 50 was investigated by the number of leukocytes and cell composition in isotonic BAL solution after 24 hours and after 8 days of the experiment. Serum levels of C-reactive protein (CRP), alkaline phosphatase (AP) and CIC were determined. Histological examination of the lungs was carried out. Results. Endotracheal injection of formalin caused irritation of the trachea and bronchi, excessive formation of bronchial secretions (heavy breathing, wheezing) in all the studied groups. The lethality of animals in the OB group on the 3rd day of the experiment (1 rat) was recorded, in the studied groups there was no death. The level of leukocytes in BAL after 24 hours exceeded the index of the IC group by 9.63 times (p<0.05), after 8 days – by 3.0 times (p<0.05). In the cellular composition of BAL, there was a significant increase in granulocytes (rod- ​​and segmented neutrophils, eosinophils), monocytes and a decrease in the lymphocyte population against the IC group. Such changes were verified in the long term (8 days of the experiment), which indicates an inflammatory process. In the group of rats that received Ledum 50, leukocytes in the BAL significantly decreased, the number of monocytes and lymphocytes in the BAL decreased, the amount of CIC in the blood serum, CRP and AP normalized. In terms of effectiveness, Ledum 50 significantly exceeded the BAL values ​​of the reference drug. The effectiveness of experimental therapy for acute bronchitis was also verified by studying the histostructure of the airways and the respiratory part of the lungs. Conclusions. Studies confirm the favorable course of acute bronchitis with Ledum 50 monotherapy. This fact is confirmed by the results of normalization of hematological parameters, leukocytes and BAL cell composition after 7 days of treatment with the claimed agent. This is the basis for further preclinical and clinical studies with the aim of creating an oral drug for the treatment of acute bronchitis.
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