EUREKA: Health Sciences

Journal Information
ISSN / EISSN : 2504-5660 / 2504-5679
Published by: OU Scientific Route (10.21303)
Total articles ≅ 360
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Siva Anoop Yella, Ramasubba Reddy, P. C. B. Gupta
Published: 31 March 2022
EUREKA: Health Sciences pp 29-54; https://doi.org/10.21303/2504-5679.2022.002384

Abstract:
Sleep is one of the essential biological rhythms of a human being. Sleep disturbances could precipitate psychiatric illnesses like schizophrenia, bipolar affective disorder, depression, anxiety disorders, substance use disorders, etc. Even when psychiatric disorders are successfully treated, sleep disturbances often fail to remit. The quality of sleep in such patients is badly affected and influences the daytime functioning and impairs the overall quality of life. The aim of the study. To study quality of sleep of patients with psychiatric illness under remission in relation to quality of life and functional disability. Material and methods. Patients attending the review outpatient department of Tertiary hospital are selected for the study. Patients diagnosed with bipolar affective disorder and schizophrenia according to ICD-10 criteria were taken. Patients meeting remission criteria for bipolar affective disorder i.e., YMRS score </=8, MADRS score </=10 and for schizophrenia –eight PANSS signs and symptoms score <3 are selected from them. Quality of sleep is compared with quality of life and functional disability. Results: Mean age was found to be 36.59. Mean PSQI score is 8.35. The mean score of physical quality of life domain is 58.28, mean score of psychological quality of life domain is 56.63, mean score of social quality of life domain is 55.39, and mean score of environmental quality of life domain is 55.41. Mean score of functional disability score is 30.14. Conclusion: Poor quality of sleep in Schizophrenia and BPAD needs to be addressed.
Svitlana Popko, Mariya Aksamytieva
Published: 31 March 2022
EUREKA: Health Sciences pp 17-22; https://doi.org/10.21303/2504-5679.2022.002272

Abstract:
The present study was aimed to evaluate the possibility of using anti-human monoclonal antibody CD3 as pan T-cell marker in the guinea pigs’ trachea and lung in early and late manifestations of the allergic inflammatory process. Materialsandmethods.We have studied the distribution and quantitative changes of CD3-positive lymphocytes in trachea and lung of guinea pigs using histological, immunohistochemical, statistical methods in conditions of experimental inflammatory process. Results. Our results revealed the applicability of anti-Human monoclonal antibody CD3 (Clone SP7, «DAKO», Denmark) cross-reaction with T-cells of guinea pigs’ tracheas and lungs. The most statistically significant elevation of the number of CD3-positive lymphocytes, in comparison with the control group (p*/**<0.05), observed in the experimental group III in the late stages of experimental inflammatory process. The elevation of the number of CD3-positive lymphocytes persists even after the termination of the allergen action, which indicates the continuation of the reaction of pulmonary local adaptive immunity to the allergen. Conclusions. The results of our study may be useful in conditions of the deficiency of guinea pig-specific tests. The immunohistochemical assessment of guinea pigs’ trachea and lungs proved the possibility to use anti-Human monoclonal antibody CD3 as a panT-cell marker in guinea pigs. We demonstrated the activation of adaptive immune response (T-cells), represented by their immunohistochemical changes, predominantly in the late stages of experimental inflammatory process.
Anna Rubinshtein,
Published: 31 March 2022
EUREKA: Health Sciences pp 10-16; https://doi.org/10.21303/2504-5679.2022.002372

Abstract:
Women of advanced maternal age (AMA) with pregnancies resulting from assisted reproductive technology (ART) have a high risk of the onset and progression of anxious and depressive disorders, associated with adverse obstetric and perinatal outcomes. The aim. To improve the mental well-being of pregnant AMA women after ART using the developed algorithm of preventive psychological support. Materials and methods. The prospective study comprised 150 patients divided into three equal groups of 50 nulliparous women aged 35–45 years with a singleton pregnancy in the cephalic presentation: the main group consolidated of pregnant women after ART who have got routine psychological support; patients with a pregnancy after ART included to the comparison group and patients with a spontaneous pregnancy from the control group were not consulted routinely. To estimate the psychological condition of the patients the level of maternal anxiety using the Spielberg State-Trait Anxiety Inventory (STAI); sleep quality using Pittsburgh Sleep Quality Index (PSQI); the presence of depressive manifestations using Edinburgh Postnatal Depression Scale (EPDS) were assessed. Results. We did not observe a significant difference in trait (TA) and state anxiety (SA) levels between the main and comparison groups at terms of 22–24 weeks of gestation; however, these values were significantly lower in the control group. The numbers of patients with high TA and SA levels in the main and comparison groups were also significantly higher than in the control group (p<0.05). We observed no significant increase in TA and SA levels in the main group at gestational terms of 35–37 weeks, in contrast to the comparison and control group. The number of patients with high TA and SA levels in the main group remained significantly lower than in the comparison group. A gradual decrease in TA and SA levels in all groups was observed in the postpartum period, but the differences between the groups remained consistent. We did not observe a significant difference in sleep quality score between the study groups at terms of 22–24 weeks of gestation. Patients of all study groups reported sleep disturbance with the pregnancy progression, but average PSQI values at terms of 35–37 weeks of gestation and 6-8 weeks after delivery were significantly lower in the main group compared to the comparison group. The incidence and severity of postnatal depressive symptoms, along with the number of patients at high risk of developing depression in the postpartum, were significantly lower in the main group than in the comparison group. Conclusions. AMA patients after ART formed a high-risk group for developing anxious and depressive disorders during the pregnancy and postpartum. High anxiety levels compromised sleep patterns have leaded to poorer quality of life of women. Preventive psychological support for patients during the pregnancy and postpartum enabled early detection and correction of depressive symptoms; validly reduced anxiety levels, improved sleep quality and consequently improved the quality of life of women and prevented adverse obstetric, perinatal, and psychiatric outcomes
, Nejla Ozkan Yildirim, Utkucan Gursoy, Okan Güleryüz, Ismail Demir, Arif Yüksel
Published: 31 March 2022
EUREKA: Health Sciences pp 3-9; https://doi.org/10.21303/2504-5679.2022.002348

Abstract:
The aim: The Japanese word “ikigai” indicates “something to live for” and “having a purpose in life”. Ikigai or well-being, has been associated with many positive outcomes in the physical and mental health of elderly people. In this study, the relationship between ikigai and level of physical activity and polypharmacy was examined in a Turkish population. Material and methods: Both telephonic interviews and face-to-face interviews were conducted with 307 participants (59.2 % women) who completed the Ikigai-9 Turkey Scale and provided demographic information. Results: Correlations between groups (polypharmacy vs. non-polypharmacy) were analyzed with an independent t-test and analysis of variance. The means of the ikigai scores were statistically significant in the polypharmacy (24.04±8.72) and non-polypharmacy 32.64±7.53) groups (p<0.05). The number of drugs used was negatively correlated with duration of exercise per week (1.32±1.82, correlation coefficient = 0.538, p<0.05). Conclusions: The level of ikigai was negatively correlated with polypharmacy and positively correlated with duration of physical activity. An individual’s ikigai should be assessed by healthcare providers to maximize positive outcomes later in life
Neeru Ghalawat, Jitender Sharma, Surinder Singh, Vivek Singh Malik
Published: 31 March 2022
EUREKA: Health Sciences pp 23-28; https://doi.org/10.21303/2504-5679.2022.002331

Abstract:
Calcaneum is the largest tarsal bone in the foot, which participate in the formation of subtalar joint. Aims and objectives The difference in the anatomical structure of calcaneum plays an important role in dynamic, kinetic, and static of the foot. Hence this study was planned. Material and methods. Present study was conducted in Pt. B. D. Sharma University of health sciences on 54 pair of dry human calcanei in which linear measurements were taken using digital vernier caliper with accuracy of 0.01mm and Bohler’s angle (BA) was measured with goniometer. Correlation of Bohler’s angle and maximum antero-posterior length (MXL) with another parameter were seen. Results. In present study no significant difference was seen in the measurements of right and the left calcanei. Correlation of MXL of calcaneum with other parameters was done which came out to be significant except for CFH (right side) and DAFW (right side). Presented findings suggest that the MXL of the calcaneum bone can sometimes be calculated from its other parameters if well preserved, which could be helpful for forensic experts. Conclusion. Present study on morphometric parameters of calcaneum would provide useful information for orthopaedic surgeries. Also, the knowledge of morphometry of this bone would be useful for forensic experts, foot rehabilitation procedure, and this study would contribute to the anatomic literature and clinical fields.
Volodymyr Konovalenko, Oleg Drobotun, Nikolai Ternovyy, Sergii Konovalenko, Oksana Garashchenko
Published: 31 January 2022
EUREKA: Health Sciences pp 37-48; https://doi.org/10.21303/2504-5679.2022.002270

Abstract:
The aim. To increase the efficiency of treatment of BC patients with metastatic lesions of long tubular bones by using, Multidetector computed tomography (MDCT) and bone marrow markers for diagnostics and monitoring the clinical course of the oncologic process, accompanied by surgical intervention with endoprosthetics along with the treatment of polymorbid pathology in a specific patient. Materials and methods. Authors provide systemic personification including visualization of the tumor site and its vascularization; printing out the 3D model; surgical planning, including optimal surgical access to the tumor site considering the volume and topographic and anatomical location and dissemination of the tumor, the convenience of intraoperative tasks (removal of the tumor, bone grafting or endoprosthetics), preoperative planning of bone resection lines with maximum preservation of intact bone tissue. Results. Personalization of the treatment of breast cancer patients with metastatic bone lesions contributes to a significant reduction in postoperative complications of endoprosthetic replacement of large joints (up to 15.2 %) and increases the overall three-year survival rate (up to 40.6 %), as well as significantly improves their quality of life. Conclusions. The personalization of treatment of patients with tumor lesions of the skeletons contributes to a significant decrease in the indicator of postoperative complications of endoprosthetics of great joints and to an increase in the total three-year survival rate, as well as to the improvement of the quality of life after the conducted treatment.
Tatiana Pochuiеva, Anna Filatova, Iryna Filatova
Published: 31 January 2022
EUREKA: Health Sciences pp 17-29; https://doi.org/10.21303/2504-5679.2022.002280

Abstract:
The aim of the research: study of the features of the clinical course of acute otitis media (AOM) in patients with impaired carbohydrate metabolism. Materials and methods. We examined 140 patients with AOM aged 19 to 72 years, of which 75 patients with impaired carbohydrate metabolism constituted the main group and 65 patients were included in the comparison group. Taking into account the peculiarities of the pathogenesis of AOM and disorders of carbohydrate metabolism, patients were randomized into 4 groups: 1 – patients with AOM (36), 2 – patients with AOM on the background of sinusitis (29), 3 – patients with AOM on the background of non-insulin-dependent diabetes mellitus (DM type II) (37), 4 – AOM patients with impaired glucose metabolism (38). The patients underwent a general clinical examination, determination of glycosylated hemoglobin, leukocyte indices of intoxication, audiometry, computed tomography (CT) of the temporal bones (if indicated). Results. The proportion of patients with impaired carbohydrate metabolism in 2020 was 32.6 %, of which DM type II was diagnosed in 49.3 % earlier. It was shown that a feature of the clinical course of AOM against the background of impaired carbohydrate metabolism is the discrepancy between the duration of the disease history, complaints and objective data to the state of the cellular structure of the mastoid process according to CT data and impaired auditory function mainly by the type of sound perception, which indicates the formation of latent mastoiditis. Clinically significant complaints and objective data for the differential diagnosis of latent mastoiditis in these patients were determined. The absence of statistical significance of differences in indicators in patients with DM type II and against the background of transient hyperglycemia was revealed, and the concept of the latter was characterized. A direct correlation between blood glucose levels and glycated hemoglobin levels was established in patients with DM type II and AOM. Conclusions. DM type II creates a favorable background for the formation of the clinical course of AOM complicated by latent mastoiditis. From the general contingent of patients with AOM, patients should be distinguished not only with DM type II, but also with transient hyperglycemia for its timely diagnosis. Significant symptoms: pain and a feeling of “heaviness” in the behind-the-ear region in the absence of reactive phenomena, a feeling of “pulsation” in the ear, dizziness, a cloudy eardrum with a protrusion or perforation in the posterior or posterior-upper section, an asymmetric increase in sound perception thresholds above 25 dB. Such patients should be observed with “early” CT scan of the temporal bones.
Yuliia Kushch
Published: 31 January 2022
EUREKA: Health Sciences pp 49-55; https://doi.org/10.21303/2504-5679.2022.002277

Abstract:
The aim of this study: to identify and analyze changes in the lifestyle and psychological sphere of students who are undergoing online training in quarantine isolation due to the COVID-19 pandemic. Material and methods: 160 students were examined for the myopic refraction using the Duochrome Test, as well as shifts in the quality of vision as a result of online learning. All participants were also interviewed to ascertain living conditions and psychological status during domestic learning related to COVID-19 isolation. Result: it was found that 42.5 % participants have myopia, most of them students of 1 and 4 courses (26.5 % and 30.9 %, respectively). 85.6 % respondents noted deterioration in health after long-term visual work with personal computer and/or smartphone. The leading symptoms associated with work on digital displays were: decreased visual acuity and binocular vision disorders (81.9 %), headache (75.6 %), back muscle pain (71.9 %), eyes redness (55.6 %), dry and itchy eyes (45 % of respondents). It has been established what 75.6 % respondents indicated deterioration in their psychological condition as a result of quarantine restrictions: 68.1 % – stress, 48.8 % – emotional instability (irritability), 51.9 % – sleep disorders (insomnia), 16.3 % – depression. It is determined that daily average working time in the conditions of domestic online learning was 6.4±2.6 hours (compared to 4.1±1.7 hours in the pre-quarantine period). Conclusion: revealed deterioration in the quality of vision, general well-being and the psychological sphere of students who are undergoing online quarantine training due to the COVID-19 pandemic.
Anna Voitiuk
Published: 31 January 2022
EUREKA: Health Sciences pp 56-62; https://doi.org/10.21303/2504-5679.2022.002179

Abstract:
Lifetime visualization of structural morphological changes of the brain in patients suffering from epilepsy and epileptic syndromes has become possible due to the introduction of neuroimaging methods into everyday medical practice. At the same time, neuroimaging is the main method of determining the etiology of epilepsy and its taxonomic position. One of these methods is magnetic resonance imaging (MRI). MRI is the method of choice in the examination of patients with diseases associated with brain development abnormalities. The aim of this study is to consider the importance of using neuroimaging methods in this clinical case of epilepsy in a young person, taking into account complaints, anamnesis of the disease and life, neurological status, laboratory results for the correct diagnosis. Conclusion. The presented clinical case of symptomatic epilepsy with focal vegetative-sensory seizures of medium frequency due to mass formation of the medial part of the right temporal lobe demonstrates the need and importance of a comprehensive examination using neuroimaging methods to clarify the etiology of the disease. Thus, magnetic resonance imaging has a high diagnostic value. This article discusses the importance of MRI for the diagnosis of epilepsy and its etiology in a young man.
Mariia Brynza, Natalia Lisova
Published: 31 January 2022
EUREKA: Health Sciences pp 10-16; https://doi.org/10.21303/2504-5679.2022.002278

Abstract:
The benefit of radiofrequency ablation (RFA) in rhythm control in atrial fibrillation (AF) and flutter patients is uncertain, but risk of death, arrhythmia recurrence and other post ablation complications remains high. Existing data on the impact of pulmonary vein isolation and cava-tricuspid isthmus RFA on long-term prognosis of patients with AF and flutter and its advantage over pharmacological antiarrhythmic therapy (AAT) are insufficient and contradictory. The aim: we sought to evaluate two-year outcomes of pulmonary vein isolation and cava-tricuspid isthmus RFA vs pharmacological only AAT according to a single center experience. Material and methods: we enrolled 174 patients after pulmonary vein isolation RFA, cava-tricuspid isthmus RFA and their combination and 122 patient who did not undergo RFA and got pharmacological AAT only. Results: there was no significant difference in mortality between the RFA and AAT only groups (5.8 % and 9.0 % respectively) with the same structure of causes of death. The Caplan-Meyer curve analysis demonstrated better survivance (p=0.031) after RFA just during first year of observation. RFA effectiveness in arrhythmia relapse prevention was the highest for cava-tricuspid isthmus RFA procedure and worst – in group of combined pulmonary vein isolation and cava-tricuspid isthmus procedures. RFA showed an advantage over AAT in smaller quantities of non-fatal cardiovascular events (p<0.001) and cardiovascular hospitalizations (p=0.0026). Conclusions: RFA of pulmonary vein isolation and cava-tricuspid isthmus RFA decrease arrhythmia episodes frequency, risk of non-fatal cardiovascular events and cardiovascular hospitalizations. Timely combined PVI and CTI procedure is associated with worsening of all outcomes.
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