Free Radical Biology and Medicine

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ISSN / EISSN : 08915849 / 18734596
Current Publisher: Elsevier BV (10.1016)
Total articles ≅ 20,005
Google Scholar h5-index: 81
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Latest articles in this journal

Yifan Zhang, YaCong He, Meiling Wu, Hansen Chen, Lu Zhang, Dan Yang, Qi Wang, Jiangang Shen
Published: 9 August 2020
Free Radical Biology and Medicine; doi:10.1016/j.freeradbiomed.2020.06.034

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Clare Stretton, Jamie N. Pugh, Brian McDonagh, Anne McArdle, Graeme L. Close, Malcolm J. Jackson
Published: 9 August 2020
Free Radical Biology and Medicine; doi:10.1016/j.freeradbiomed.2020.06.020

Abstract:
Skeletal muscle generates superoxide during contractions which is rapidly converted to H2O2. This molecule has been proposed to activate signalling pathways and transcription factors that regulate key adaptive responses to exercise but the concentration of H2O2 required to oxidise and activate key signalling proteins in vitro is much higher than the intracellular concentration in muscle fibers following exercise. We hypothesised that Peroxiredoxins (Prx), which reacts with H2O2 at the low intracellular concentrations found in muscle, would be rapidly oxidised in contracting muscle and hence potentially transmit oxidising equivalents to downstream signalling proteins as a method for their oxidation and activation. The aim of this study was to characterise the effects of muscle contractile activity on the oxidation of Prx1, 2 and 3 and determine if these were affected by aging. Prx1, 2 and 3 were all rapidly and reversibly oxidised following treatment with low micromolar concentrations of H2O2 in C2C12 myotubes and also in isolated mature flexor digitalis brevis fibers from adult mice following a protocol of repeated isometric contractions. Significant oxidation of Prx2 was seen within 1 minute (i.e. after 12 contractions), whereas significant oxidation was seen after 2 minutes for Prx1 and 3. In muscle fibers from old mice, Prx2 oxidation was significantly attenuated following contractile activity. Thus we show for the first time that Prx are rapidly and reversibly oxidised in response to contractile activity in skeletal muscle and hypothesise that these proteins act as effectors of muscle redox signalling pathways which are key to adaptations to exercise that are attenuated during aging.
C. Lopez-Alarcon, Eduardo Fuentes-Lemus, Juan David Figueroa, Eva Dorta, Christian Schöneich, Michael J. Davies
Published: 7 August 2020
Free Radical Biology and Medicine; doi:10.1016/j.freeradbiomed.2020.06.021

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Chan Mo, Shuwen Xie, Weichao Zhong, Ting Zeng, Sha Huang, Yuqi Lai, Guanghui Deng, Chuying Zhou, Weixin Yan, Yuyao Chen, et al.
Published: 6 August 2020
Free Radical Biology and Medicine; doi:10.1016/j.freeradbiomed.2020.07.038

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Maria Paola Paronetto, Ivan DiMauro, Elisa Grazioli, Ramona Palombo, Flavia Guidotti, Cristina Fantini, Paolo Sgrò, Dario De Francesco, Luigi Di Luigi, Laura Capranica, et al.
Published: 5 August 2020
Free Radical Biology and Medicine; doi:10.1016/j.freeradbiomed.2020.06.037

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Tao Bai, Mingxing Li, Yuanfeng Liu, Zhentao Qiao, Zhiwei Wang
Published: 5 August 2020
Free Radical Biology and Medicine; doi:10.1016/j.freeradbiomed.2020.07.026

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Olga Utyro, Joanna Perła-Kaján, Jolanta Kubalska, Ałła Graban, Hieronim Jakubowski
Published: 5 August 2020
Free Radical Biology and Medicine; doi:10.1016/j.freeradbiomed.2020.07.036

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Anitra C. Carr, Emma Spencer, Diane Mackle, Anna Hunt, Harriet Judd, Jan Mehrtens, Kim Parker, Zoe Stockwell, Caitlin Gale, Megan Beaumont, et al.
Published: 5 August 2020
Free Radical Biology and Medicine; doi:10.1016/j.freeradbiomed.2020.06.018

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F. Sánchez-Rubio, P.J. Soria-Meneses, A. Jurado-Campos, J. Bartolomé-García, V. Gómez-Rubio, A.J. Soler, M.M. Arroyo-Jimenez, M.J. Santander-Ortega, M. Plaza-Oliver, M.V. Lozano, et al.
Published: 5 August 2020
Free Radical Biology and Medicine; doi:10.1016/j.freeradbiomed.2020.07.024

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Suma Elumalai, Udayakumar Karunakaran, Jun Sung Moon, Kyu Chang Won
Published: 5 August 2020
Free Radical Biology and Medicine; doi:10.1016/j.freeradbiomed.2020.07.030

The publisher has not yet granted permission to display this abstract.
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