Biochemical and Biophysical Research Communications

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ISSN / EISSN : 0006-291X / 1090-2104
Published by: Elsevier BV (10.1016)
Total articles ≅ 94,468
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Latest articles in this journal

Yutaka Shindo, Keigo Fujita, Mari Tanaka, Hiroki Fujio, ,
Biochemical and Biophysical Research Communications; https://doi.org/10.1016/j.bbrc.2021.10.046

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Meiling Lu, Lei Yu, Yanrong Yang, Jiali Zhu, Sujing Qiang, Xinbo Wang, Jia Wang, Xiao Tan, Weifeng Wang, Yue Zhang, et al.
Biochemical and Biophysical Research Communications; https://doi.org/10.1016/j.bbrc.2021.10.014

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Junrui Zhou, Tingfang Li, Xin Geng, ,
Biochemical and Biophysical Research Communications; https://doi.org/10.1016/j.bbrc.2021.10.034

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Yanling Su, Ping Guan, Dandan Li, Yanwen Hang, Xiaomiao Ye, Lu Han, Yi Lu, Xiaolu Bai, ,
Biochemical and Biophysical Research Communications; https://doi.org/10.1016/j.bbrc.2021.10.038

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Taro Umezu, Satoshi Nakamura, Yuiko Sato, Tami Kobayashi, Eri Ito, Takaya Abe, Mari Kaneko, Masatoshi Nomura, Akihiko Yoshimura, Akihito Oya, et al.
Biochemical and Biophysical Research Communications; https://doi.org/10.1016/j.bbrc.2021.10.043

Abstract:
Skeletal muscle is known to regulate bone homeostasis through muscle-bone interaction, although factors that control this activity remain unclear. Here, we newly established Smad3-flox mice, and then generated skeletal muscle-specific Smad2/Smad3 double conditional knockout mice (DcKO) by crossing Smad3-flox with skeletal muscle-specific Ckmm Cre and Smad2-flox mice. We show that immobilization-induced gastrocnemius muscle atrophy occurring due to sciatic nerve denervation was partially but significantly inhibited in DcKO mice, suggesting that skeletal muscle cell-intrinsic Smad2/3 is required for immobilization-induced muscle atrophy. Also, tibial bone atrophy seen after sciatic nerve denervation was partially but significantly inhibited in DcKO mice. Bone formation rate in wild-type mouse tibia was significantly inhibited by immobilization, but inhibition was abrogated in DcKO mice. We propose that skeletal muscle regulates immobilization-induced bone atrophy via Smad2/3, and Smad2/3 represent potential therapeutic targets to prevent both immobilization-induced bone and muscle atrophy.
Ryotaro Shioda, Airi Jo-Watanabe, , Ken Yasukawa, Toshiaki Okuno, Yusuke Suzuki,
Biochemical and Biophysical Research Communications, Volume 582, pp 49-56; https://doi.org/10.1016/j.bbrc.2021.10.028

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Weifeng Zhang, Bing Li, Nannan Xia, Lijuan Zhu, Zhenshan Zhang, Zhijuan Ren, Luyue Zhang, Pengfei Xu, Feilong Meng, Lixin Feng, et al.
Biochemical and Biophysical Research Communications; https://doi.org/10.1016/j.bbrc.2021.10.040

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Huayuan Liu, Mengya Wang, Zhipeng Jin, Dongxu Sun, Ting Zhu, Xinyue Liu, ,
Biochemical and Biophysical Research Communications, Volume 582, pp 77-85; https://doi.org/10.1016/j.bbrc.2021.10.041

Abstract:
The purpose of this study was to investigate the effect of FNDC5 expression levels in hepatocellular carcinoma on the phenotypic changes of macrophages in tumor tissues.
Weizhou Wang, Yanghao Wang, Zhihong Tang, Yongcheng Chen, Zhui Liu, Hao Duan, Zongyu Zhong,
Biochemical and Biophysical Research Communications, Volume 582, pp 64-71; https://doi.org/10.1016/j.bbrc.2021.10.033

Abstract:
Mesenchymal stem cells (MSCs) can promote osteogenesis and are a promising therapy for postmenopausal osteoporosis. However, the relationship between improved intraosseous microcirculation and increased bone mass induced by MSCs in postmenopausal osteoporosis remains unclear. After the primary MSCs were characterized, they were transplanted into ovariectomized mice. MSCs transplantation enhanced the trabecular number, trabecular bone volume/total volume, and trabecular bone mineral density in ovariectomized mice. To determine the role of MSCs in vascular repair, mice were subjected to femoral artery ligation. Through laser speckle flowmetry, vascular perfusion and femoral trabecular bone and cortical bone analyses, we determined the effects of MSCs in promoting intraosseous angiogenesis and preventing osteoporosis in mice. MSCs effectively prevented postmenopausal osteoporosis development, which is associated with the involvement of MSCs in reestablishment of microcirculation within the skeleton.
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