Biochemical and Biophysical Research Communications

Journal Information
ISSN / EISSN : 0006-291X / 1090-2104
Current Publisher: Elsevier BV (10.1016)
Former Publisher: Elsevier BV (10.1006)
Total articles ≅ 93,613
Current Coverage
SCOPUS
PUBMED
MEDLINE
MEDICUS
SCIE
Archived in
SHERPA/ROMEO
EBSCO
Filter:

Latest articles in this journal

Yingxue Gao, Yuxin Fu, Jia Wang, Xiang Zheng, ,
Biochemical and Biophysical Research Communications, Volume 547, pp 1-8; doi:10.1016/j.bbrc.2021.02.014

The publisher has not yet granted permission to display this abstract.
Ping Chen, Min Pan, Qing-Song Lin, Xian-Zhong Lin,
Biochemical and Biophysical Research Communications, Volume 547, pp 36-43; doi:10.1016/j.bbrc.2021.02.010

The publisher has not yet granted permission to display this abstract.
Zhiping Liu, Wen Xu, ,
Biochemical and Biophysical Research Communications, Volume 548, pp 53-59; doi:10.1016/j.bbrc.2021.02.056

The publisher has not yet granted permission to display this abstract.
Ha-Won Jeong, Ran Hee Choi,
Biochemical and Biophysical Research Communications, Volume 547, pp 29-35; doi:10.1016/j.bbrc.2021.01.103

The publisher has not yet granted permission to display this abstract.
Rui Xiang, Junchao Wang, Wenjuan Xu, ,
Biochemical and Biophysical Research Communications, Volume 547, pp 59-64; doi:10.1016/j.bbrc.2021.02.022

The publisher has not yet granted permission to display this abstract.
Xuebin Wang, Tianjia Li, Baitao Ma, Zhewei Zhao, Leng Ni, Rui Zhang, Shuai Niu,
Biochemical and Biophysical Research Communications, Volume 548, pp 127-133; doi:10.1016/j.bbrc.2021.02.070

The publisher has not yet granted permission to display this abstract.
Rutambhara Purohit,
Biochemical and Biophysical Research Communications, Volume 548, pp 143-147; doi:10.1016/j.bbrc.2021.02.060

The publisher has not yet granted permission to display this abstract.
Biochemical and Biophysical Research Communications, Volume 547; doi:10.1016/s0006-291x(21)00323-5

Fan Ying, Hao Liu, Eva Hoi Ching Tang, Ishan Lakhani, Ningning Liu, Zhengyuan Xia,
Biochemical and Biophysical Research Communications, Volume 548, pp 196-203; doi:10.1016/j.bbrc.2021.01.038

Abstract:
Cardiac fatty acid metabolism is essential for maintaining normal cardiac function at baseline and in response to various disease stress, like diabetes. EP4 is widely expressed in cardiomyocytes and has been demonstrated to play a role in cardio function. However, its function in regulating cardiac fatty acid metabolism is remained unknown. Mice were fed with standard chow or high-fat for eight weeks. The effects of EP4 deficiency on cardiac function, cardiomyocytes hypertrophy and myocardial fibrosis were studied. The possible regulatory mechanisms were further investigated. EP4−/− mice exhibited concentric hypertrophy and myocardial fibrosis with cardiac energy deprivation due to reduction of fatty acid uptake and inhibition of ATP generation mediated by FOXO1/CD36 signalling. Moreover, pharmacologically activated EP4 alleviated impaired fatty acid transport and insufficient ATP generation in cardiomyocytes. EP4 tightly coordinates the rates of cardiac fatty acid uptake and ATP generation via FOXO1/CD36 signalling axis. Our study provides evidences for the link between EP4 and cardiac fatty acid transport and further pointed out that EP4 could be a potential target for modulating fatty acid metabolism and curbing cardiac tissue-specific impairment of function following diabetes.
ChiuJung Yang, Kazuhiro Ikeda, Kuniko Horie-Inoue, Wataru Sato, , Satoru Takeda, Atsuo Itakura,
Biochemical and Biophysical Research Communications, Volume 548, pp 204-210; doi:10.1016/j.bbrc.2021.02.066

The publisher has not yet granted permission to display this abstract.
Back to Top Top