European Journal of Pharmaceutics and Biopharmaceutics

Journal Information
ISSN / EISSN : 0939-6411 / 1873-3441
Current Publisher: Elsevier BV (10.1016)
Former Publisher: Elsevier BV (10.116)
Total articles ≅ 5,457
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European Journal of Pharmaceutics and Biopharmaceutics; doi:10.1016/j.ejpb.2021.03.015

Abstract:
In the pharmaceutical industry, cryoprotectants are added to buffer formulations to protect the active pharmaceutical ingredient from freeze- and thaw damage. We investigated the freezing and thawing of aqueous sodium citrate buffer with various cryoprotectants, specifically amino acids (cysteine, histidine, arginine, proline and lysine), disaccharides (trehalose and sucrose), polyhydric alcohols (glycerol and mannitol) and surfactants (polysorbate 20 and polysorbate 80). Hereby, we employed optical cryomicroscopy in combination with differential scanning calorimetry in the temperature range to -80°C. The effect of cryoprotectants on the morphology of the ice crystals, the glass transition temperature and the initial melting temperature is presented. Some of the cryoprotectants have a significant impact on ice crystal size. Disaccharides restrict ice crystal growth, whereas surfactants and glycerol allow ice crystals to increase in size. Cysteine and mannitol cause dehydration after thawing. Either one or two glass transition temperatures were detected, where arginine, surfactants, glycerol, proline and lysine suppress the second, implying a uniform freeze-concentrated solution. The initial melting temperature of pure buffer solution can be shifted up by adding mannitol, both disaccharides and both surfactants; but down by glycerol, proline and lysine.
Constança Oliveira, João Calmeiro, Mylène A. Carrascal, Amílcar Falcão, Célia Gomes, Bruno Miguel Neves,
European Journal of Pharmaceutics and Biopharmaceutics, Volume 161, pp 4-14; doi:10.1016/j.ejpb.2021.02.002

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Pinal Chaudhari, Vivek M. Ghate,
European Journal of Pharmaceutics and Biopharmaceutics, Volume 161, pp 80-99; doi:10.1016/j.ejpb.2021.02.007

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Jiaojiao Yu, Xue Meng, Xue Dong, Mengfan Han, Guotao Li, Yanna Chen, ,
European Journal of Pharmaceutics and Biopharmaceutics; doi:10.1016/j.ejpb.2021.03.014

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Michael Karimov, Dietmar Appelhans, Alexander Ewe,
European Journal of Pharmaceutics and Biopharmaceutics, Volume 161, pp 56-65; doi:10.1016/j.ejpb.2021.02.005

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Soma Patnaik, Bapi Gorain, Santwana Padhi, Hira Choudhury, Gamal A. Gabr, Shadab, ,
European Journal of Pharmaceutics and Biopharmaceutics, Volume 161, pp 100-119; doi:10.1016/j.ejpb.2021.02.010

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, Jakub Włodarczyk, Mateusz Stojko, Paulina Karpeta-Jarząbek, Małgorzata Pastusiak, Henryk Janeczek, Janusz Kasperczyk
European Journal of Pharmaceutics and Biopharmaceutics, Volume 161, pp 29-36; doi:10.1016/j.ejpb.2021.02.001

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European Journal of Pharmaceutics and Biopharmaceutics, Volume 161; doi:10.1016/s0939-6411(21)00063-1

Christoph Marschall, Madlen Witt, Bernhard Hauptmeier,
European Journal of Pharmaceutics and Biopharmaceutics, Volume 161, pp 37-49; doi:10.1016/j.ejpb.2021.01.014

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Rishi Thakkar, Yu Zhang, JiaXiang Zhang,
European Journal of Pharmaceutics and Biopharmaceutics; doi:10.1016/j.ejpb.2021.03.016

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