Nature Genetics

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ISSN / EISSN : 1072-8368 / 1546-1718
Published by: Springer Nature (10.1038)
Total articles ≅ 11,716
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, , Bjarni A. Atlason, Gardar Sveinbjornsson, Magnus I. Magnusson, Edda L. Styrmisdottir, Kristbjorg Gunnarsdottir, , , , et al.
Published: 2 December 2021
The publisher has not yet granted permission to display this abstract.
Luz Garcia-Alonso, Louis-François Handfield, Kenny Roberts, Konstantina Nikolakopoulou, Ridma C. Fernando, Lucy Gardner, Benjamin Woodhams, Anna Arutyunyan, , Regina Hoo, et al.
Published: 2 December 2021
Abstract:
The endometrium, the mucosal lining of the uterus, undergoes dynamic changes throughout the menstrual cycle in response to ovarian hormones. We have generated dense single-cell and spatial reference maps of the human uterus and three-dimensional endometrial organoid cultures. We dissect the signaling pathways that determine cell fate of the epithelial lineages in the lumenal and glandular microenvironments. Our benchmark of the endometrial organoids reveals the pathways and cell states regulating differentiation of the secretory and ciliated lineages both in vivo and in vitro. In vitro downregulation of WNT or NOTCH pathways increases the differentiation efficiency along the secretory and ciliated lineages, respectively. We utilize our cellular maps to deconvolute bulk data from endometrial cancers and endometriotic lesions, illuminating the cell types dominating in each of these disorders. These mechanistic insights provide a platform for future development of treatments for common conditions including endometriosis and endometrial carcinoma.
Takahiro Ito, Michael J. Young, Ruitong Li, Sidharth Jain, Andreas Wernitznig, , Christopher T. Lemke, Davide Monducci, Diego J. Rodriguez, Liang Chang, et al.
Published: 2 December 2021
The publisher has not yet granted permission to display this abstract.
, , , , , Mahan Nekoui, Shaan Khurshid, Samuel F. Friedman, Alexander G. Bick, Alessandro Arduini, et al.
Published: 26 November 2021
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Carolina Rosswog, Christoph Bartenhagen, Anne Welte, Yvonne Kahlert, Nadine Hemstedt, Witali Lorenz, Maria Cartolano, Sandra Ackermann, Sven Perner, Wenzel Vogel, et al.
Published: 15 November 2021
The publisher has not yet granted permission to display this abstract.
Daniel Holoch, Michel Wassef, , , Setareh Aflaki, Bérangère Lombard, Tiphaine Héry, , ,
Published: 15 November 2021
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