Journal Information
ISSN / EISSN : 0893-133X / 1740-634X
Current Publisher: Springer Science and Business Media LLC (10.1038)
Former Publisher: Elsevier BV (10.1016)
Total articles ≅ 7,200
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Neuropsychopharmacology pp 1-9; doi:10.1038/s41386-020-00950-y

The view that substance addiction is a brain disease, although widely accepted in the neuroscience community, has become subject to acerbic criticism in recent years. These criticisms state that the brain disease view is deterministic, fails to account for heterogeneity in remission and recovery, places too much emphasis on a compulsive dimension of addiction, and that a specific neural signature of addiction has not been identified. We acknowledge that some of these criticisms have merit, but assert that the foundational premise that addiction has a neurobiological basis is fundamentally sound. We also emphasize that denying that addiction is a brain disease is a harmful standpoint since it contributes to reducing access to healthcare and treatment, the consequences of which are catastrophic. Here, we therefore address these criticisms, and in doing so provide a contemporary update of the brain disease view of addiction. We provide arguments to support this view, discuss why apparently spontaneous remission does not negate it, and how seemingly compulsive behaviors can co-exist with the sensitivity to alternative reinforcement in addiction. Most importantly, we argue that the brain is the biological substrate from which both addiction and the capacity for behavior change arise, arguing for an intensified neuroscientific study of recovery. More broadly, we propose that these disagreements reveal the need for multidisciplinary research that integrates neuroscientific, behavioral, clinical, and sociocultural perspectives.
Pascal Roullet, Guillaume Vaiva, Etienne Véry, Axel Bourcier, Antoine Yrondi, Laetitia Dupuch, Pierre Lamy, Claire Thalamas, Laurence Jasse, Wissam El Hage, et al.
Neuropsychopharmacology pp 1-7; doi:10.1038/s41386-021-00984-w

The publisher has not yet granted permission to display this abstract.
Gianluca Ursini, Giovanna Punzi
Neuropsychopharmacology pp 1-2; doi:10.1038/s41386-021-00979-7

Sylvain Auvity, Sébastien Goutal, Fabien Caillé, Dominique Vodovar, Alain Pruvost, Catriona Wimberley, Claire Leroy, Matteo Tonietto, Michel Bottlaender,
Neuropsychopharmacology pp 1-9; doi:10.1038/s41386-021-00976-w

The publisher has not yet granted permission to display this abstract.
, W. Michael Vanderlind, George S. Alexopoulos, Chaya B. Fridman, Roy H. Perlis, Faith M. Gunning
Neuropsychopharmacology pp 1-6; doi:10.1038/s41386-021-00978-8

The publisher has not yet granted permission to display this abstract.
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