Asian Journal of Health Research

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ISSN / EISSN : 2829-2979 / 2828-9269
Total articles ≅ 7
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Ayu Rizky Widowati, Sutrisno Sutrisno
Asian Journal of Health Research, Volume 1, pp 74-78; https://doi.org/10.55561/ajhr.v1i2.27

Abstract:
Introduction: Despite the fact that zinc deficiency is asymptomatic, its incidence is rising over the world, with no visible clinical manifestation. Mineral and vitamin supplementation to prevent the inflammatory response is a major concern during the COVID-19 pandemic. Zinc may play a role in the development of a stronger immunological response. Nonetheless, there is insufficient information to investigate the benefits of zinc on its own. The impact of zinc deficiency on the severity of COVID-19 infection will be discussed in this systematic study. Material and Methods: We used the search phrases "COVID-19" or "SARS-CoV-2" and "Zinc Deficiency" to look for publications published between 2020 and April 2021 in scholar google, PubMed, SCOPUS, and Proquest. All of the information was examined qualitatively. Results: There are three papers that discuss the benefits of zinc and indicate that zinc deficiency has a key influence in the severity of COVID-19. According to one study, there is no link between zinc deficiency and COVID-19 severity. Conclusions: COVID-19 infection is linked to low zinc levels in the blood. It may become a risk factor for COVID-19 severity or a contributing factor that goes unnoticed in regular practice. Zinc supplementation or zinc baseline serum may play a role in determining potential daily supplementation and treatment for patients at risk of zinc insufficiency in the COVID-19 group in RCT and better design studies.
Bambang Rahardjo, Kunawati Tungga Dewi, Anita Dwi Rahmawati, Fauqo Wildatil Jannah, Mukhamad Nooryanto, Anin Indriani
Asian Journal of Health Research, Volume 1, pp 12-18; https://doi.org/10.55561/ajhr.v1i2.44

Abstract:
Introduction: Preeclampsia has two stages: improper placental and maternal circulation. Abnormal trophoblast invasion causes uteroplacental ischemia and hypoxia. Ischemia in the placenta produces endothelial cell dysfunction, which is defined by a change in endothelial cell activity to a reduced ability to vasodilate (decreased eNOS) and prothrombotic conditions (decreased PECAM-1). Reduced maternal eNOS activity and PECAM-1 can cause preeclampsia. Pravastatin is the statin class's most hydrophilic medication, and it limits placental transfer. Pravastatin can reduce endothelial dysfunction by targeting pleiotropic effects in pregnancy. The aim was to show the effects of pravastatin on the eNOS and PECAM-1 expression in the placenta of preeclampsia rat model. Materials and Methods: This is a true experimental study with only a post-test and a control group design. The sample was biological material in the form of placental tissue from a pravastatin-treated preeclampsia rat model (using L-NAME exposure). This research was divided into five groups, each with five samples. The parameters studied were eNOS and PECAM-1 expression. Results: The Shapiro-Wilk test result was significant (p>0.05). Annova tests on eNOS (p=0.000) and PECAM-1 expression (p=0.000) confirmed the hypothesis. The Tukey test showed significant differences in eNOS (sig. 0.001) and PECAM-1 (sig. 0.000) expression between normal and preeclampsia rats. Positive controls and treatment groups P1, P2, and P3 all showed significant changes in eNOS and PECAM-1 expression. Pravastatin dose considerably increased eNOS (p=0.015; r=0.536) and PECAM-1 (p=0.000; r=0.734) expression.. Conclusion: Pravastatin has been shown to increase eNOS and PECAM-1 expression in the placenta of preeclampsia rat model.
Mergy Gayatri, Nurul Fathiyyah, Jesica Mulyadi, Diadjeng Setya Wardani, I Wayan Agung Indrawan
Asian Journal of Health Research, Volume 1, pp 35-39; https://doi.org/10.55561/ajhr.v1i2.45

Abstract:
Introduction: Preeclampsia is a pregnancy-related complication causing maternal morbidity and mortality. This study aimed to determine the relationship between anaemia and family income, and maternal death from preeclampsia in Jember district. Materials and Methods: Case-control, using medical maternal autopsy verbal, from January 2016 to December 2019. 43 mortality cases from preeclampsia, and 43 controls were included in this study. Chi-square test was to test the relationship between anaemia and family income, and maternal death from preeclampsia. Results: Mothers who died from preeclampsia were more likely to have anaemia (83.72%), and being low income (86.05%). Anaemia (OR 3.703, 95% CI p-value 0.009) and low income (OR 4.032, 95% CI, p –value 0.007) were associated with preeclampsia maternal mortality. Conclusions: To reduce the prevalence of death from preeclampsia, preventive measurement for anaemia during pregnancy should be undertaken. In addition, women with low income during pregnancy should be encouraged to have health insurance.
Dewi Ratna Sulistina
Asian Journal of Health Research, Volume 1, pp 64-74; https://doi.org/10.55561/ajhr.v1i2.43

Abstract:
Introduction: Hepatitis B vaccination is important to protect individuals from Hepatitis B virus (HBV) infection. The aim of this study was to conduct a systematic review of the necessity of Hepatitis B vaccination among humans, especially among infants, children, teenagers, adults, risk groups, and health care workers. Methods: Three databases were used in this study, Scopus, Web of Science, and PubMed. We reported the study using PRISMA-P guidelines. The keywords were used in this study (TITLE-ABS-KEY (vaccine) AND TITLE-ABS-KEY (hepatitis AND b) AND TITLE-ABS-KEY (boost)), and we obtained 275 articles. In the web of science, we used ((ALL=(vaccine)) AND ALL= (Hepatitis B)) AND ALL=(Boost), and we obtained 374 articles. In the PubMed, we used ((Vaccine [MeSH Terms]) AND (Hepatitis b [MeSH Terms])) AND (booster immunization [MeSH Terms]), and we obtained 417 articles. Results: There were 60 articles included in this systematic review. The systematic review results showed that infants, children, and teenagers, as well as adult groups who receive the hepatitis B vaccine, can protect for 5-30 years. Meanwhile, risk group and health care workers were suggested to obtain hepatitis B vaccine booster with low anti-HBsAg titer Conclusion: It needs to conduct anti-HBs Ag titer testing to decide whether they need a hepatitis B vaccination booster. Hepatitis B vaccine booster required for the group with anti-HBs Ag titer less than 10 mIU/mL.
Maharani, Sutrisno
Asian Journal of Health Research, Volume 1, pp 7-11; https://doi.org/10.55561/ajhr.v1i2.24

Abstract:
Introduction: Endometriosis is a gynaecological disorder in women and causes infertility. Several therapeutic were developed to reduce endometriosis cases, one of them was matrix metalloproteinase (MMP) inhibitor. This study investigated the potential activity of the flavonoids in Phaleria macrocarpa fruit as MMP1 inhibitors for endometriosis. Methods: In silico modelling was used in this study. Six flavonoid structures were retrieved from PubChem NCBI database. A targeted protein, MMP1 was taken out from Protein Data Bank with ID 1CGE and predicted the active sites. Six flavonoids and MMP1 was interacted by molecular docking using Molegro virtual Docker version 5 and analyzed using PyMol 2.2 and Discovery Studio version 21.1.1. Three-dimensional complex structure of flavonoids – MMP1 showed interaction in the same active sites and performed an amino acid residue Glu219 as catalytic site. Results: Six flavonoids of Phaleria macrocarpa were divided into two patterns and generated varied binding energy. Glycitin and Catechin 7-O-beta-D-xyloside showed low score of binding energy and depicted similar structure with four aromatic rings. 8-Prenylnaringenin performed lower binding energy than naringenin, eriodictyol, and 5-O-methylgenistein. Conclusion:In silico analysis suggested that six flavonoids compounds is potent as MMP1 inhibitor and might be interfered endometriosis pathophysiology. In vivo and in vivo investigations are required for further analysis.
Md Sutrisno
Asian Journal of Health Research, Volume 1, pp 1-6; https://doi.org/10.55561/ajhr.v1i2.52

Abstract:
According to the final report of the Lancet panel on climate change [1,2], " climate change is the biggest global danger of the 21st century". The world's climate has permanently changed over time. Some regions of the Earth that are presently relatively warm were once covered in ice millions of years ago. In more recent decades, average temperatures have cycled up and down due to variations in solar radiation or the recurrent eruption of volcanoes [3]. There is broad scientific agreement that Human-caused greenhouse gas emissions are a vital contributor to global warming that is currently taking place. Global carbon dioxide emissions are rising, reaching a new high last year. Indonesians seek to fight the risk of poverty being undermined by climate change. Its effects are escalating the dangers and vulnerabilities that face the poor, adding to the strain on their already overworked coping mechanisms. Infectious diseases, malnutrition, stunting, degenerative diseases, cancer, autoimmune disease, maternal and perinatal mortality, and many more having close connection with climate change. Natural disaster to be more prevalent and aggravates the bad impact. It is need to addresses the effects of climate change on health, contemporary sociopolitical views, and the need for public health and climate change policy that places a strong emphasis on the advantages to manage climate changes in reducing health impact in Indonesia and around the world [4].
I Wayang Agung Indrawan, I Wayan Arsana Wiyasa, Achmad Hidayat, Qonita Prasta Agustia
Asian Journal of Health Research, Volume 1, pp 40-45; https://doi.org/10.55561/ajhr.v1i2.8

Abstract:
Background: Identification and isolation of local non-soy isoflavone based on cow pea (Vigna unguiculata) by The Indonesian Menopause Society (PERMI) in Malang District, Indonesia No published studies have directly examined the effect of that non-soy isoflavone on bone mineral density in menopausal women. Objective: To determine the effect of 24 weeks' consumption of non-soy isoflavone (67,5 mg) to reduce osteoporotic bone loss in menopausal women. Design and Methods: Menopausal subjects were randomly assigned, double-blind to treatment: non-soy isoflavone (n-30), or placebo (n-30). At baseline and posttreatment, bone mineral density (BMD) was measured by using quantitative ultrasonography. Collected data were analyzed by Analysis of Covariance (ANCOVA). Results: There were no differences in BMD changes between the treatment and placebo group for 24 weeks intervention. The mean of BMD changes in treatment group were 0,952 (p-value 0,006, SE-0,221) from baseline, and the placebo group had mean at -0,768 (p-value -0,006, SE-0,212). Despite this, coffee as the concomitant variable had a significant effect on BMD changes (p value=0,43) at 3rd-month evaluation, but not in 6 months. Participant compliance is good. Conclusion: Non-soy Isoflavone attenuates bone loss in menopausal women. Keywords: non-soy, phytoestrogen, osteoporosis, postmenopausal women
Annissa Febriani, Donny Wisnu Wardhana, Nugrahanti Prasetyorini, Pande Made Dwijayasa
Asian Journal of Health Research, Volume 1, pp 46-51; https://doi.org/10.55561/ajhr.v1i2.19

Abstract:
Introduction: Secondary amenorrhea has a broad etiology, so each case must be studied in depth. One of the causes of secondary amenorrhea is a state of hyperprolactinemia caused by a mass in the anterior pituitary. Pituitary macroadenoma patients may be asymptomatic or have a hormone imbalance or mass impact symptoms. Tumors in asymptomatic patients might be identified during a routine head imaging examination for unrelated medical issues. Case Presentation: A 24-year-old unmarried woman with complaints of headache, blurred vision, and worsening for one year ago. The patient complained of not having menstruation in the past five years ago, with a history of previous normal menstruation. On physical examination, found breast and pubic Tanner stage 5. On laboratory examination, it was found FSH (2.21), Oestradiol (20.23), and Prolactin (1365.47). On an MRI of the head examination on April 14, 2021, a solid intrasellar mass of suspected pituitary macroadenoma was found with a size of ± 1.3 cm x 1.4 cm x 1.6 cm. Conclusion: Secondary amenorrhea caused by hyperprolactinemia due to pituitary macroadenoma is a rare case (40%). First-line therapy for prolactinomas is dopamine agonist administration because most pituitary macroadenomas respond to dopamine agonists.
, Hendra Brahmantyo Ratsamanda, I Wayan Arsana Wiryasa, Steven Christian Susianto, Burhan Mahendra Kusuma
Asian Journal of Health Research, Volume 1, pp 25-28; https://doi.org/10.55561/ajhr.v1i2.3

Abstract:
Introduction: The prevalence of endometriosis in women of reproductive age was still high. A previous study showed that the red fruit (Pandanus conoideus L.) extract consisted of alpha-tocopherol and beta carotene as antioxidants that could potentially be an alternative treatment in endometriosis. This study aimed to determine the effect of Red Fruit Extract Administration on the expression of TNF-α, microvessels density (MVD), and the area of endometriosis implant in endometriosis mice model. Methods: This was an experimental study with a randomized post-test control group design only applied to the endometriosis mice model and conducted in the Veterinary Faculty of Medicine Airlangga University, Surabaya. Twenty-eight endometriosis model mice were randomly divided into two groups. The control group (K) received CMC Na 5% for 14 days, and the treatment group (P) was given Red Fruit extract of 0,05 ml/day for 14 days. After day 28, mice were sacrificed, and immunohistochemical analysis was performed for TNF-α, microvessel density (MVD), and measured for endometriosis implant area. A T-test was used to analyze the comparison between groups. Results: Mean TNF-α, microvessel density, area of endometriosis implant in treatment group were 1,56±0,87, 1,26±0,48, 13,24±4,08, respectively. There was a statistically significant difference in TNF-α expression, MVD development, and area of endometriosis implant between the treatment and control groups (p<0.05). Conclusion: There was decreased expression of TNF-α, development of microvessel density, and area of endometriosis implant in endometriosis mice model given red fruit extract and proved to have potential effect as endometriosis therapy.
Herdian Fitria Widyanto Putri, Qatrunnada Naqiyyah Khusmitha, Galih Puspita Citra Mahardhika, Dwi Yuni Nur Hidayati, Tri Yudani Mardining Raras, Eviana Norahmawati
Asian Journal of Health Research, Volume 1, pp 19-24; https://doi.org/10.55561/ajhr.v1i2.40

Abstract:
Introduction: Candida albicans causes the second most frequent vaginal infection, vulvovaginal candidiasis (VVC). Bajakah Tampala is a natural plant of Kalimantan that has the potential to be used as a traditional remedy for various diseases. This study aims to determine the phytochemical content and antifungal potential of methanol and ethanol Bajakah Tampala stem extract against the growth of Candida albicans.Methods:Flavonoids, tannin, phenol, and saponin were identified through qualitative analysis of the phytochemical content. Different concentration of Bajakah Tampala methanol and ethanol extract (1.56%, 3.175%, 6.25%, 12.5%, 25%, 50%, and 100%) was tested for antifungal potency using dilution method. The extract that could inhibit the growth of Candida albicans colonies was continued with the concentration density (35%, 37.5%, 40%, 42.5%, 45%, 47.5%, and 50%) in order to determine the Minimum Inhibitory Concentration (MIC) and Minimum Killing Concentration (MKC) by counting the number of colonies. Results: The methanol extract of Bajakah Tampala contains flavonoids, tannins, phenol, and saponin. In contrast, no flavonoids were detected in the ethanol extract. Candida albicans colonies were not inhibited by concentrations of 1.56%, 3.125%, 6.25%, 12.5%, and 25% in ethanol and methanol extracts, respectively. At concentrations of 50% and 100%, methanol extract inhibits colony growth, but ethanol extract is still growing. The antifungal activity of methanol extract showed a MIC of 35% and a MKC of 47.5%, as measured by its concentration density. Conclusion:Flavonoids are present in the Bajakah Tampala methanol extract, which inhibits and kills the growth of Candida albicans but not ethanol.
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