Research & Review: Drugs and Drugs Development

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EISSN : 2582-5720
Total articles ≅ 3
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Indu, Sachin Goyal, Shivali Singla
Research & Review: Drugs and Drugs Development, Volume 4, pp 1-10; https://doi.org/10.46610/rrddd.2022.v04i02.001

Abstract:
Tropicamide is an anticholinergic drug which is used in the treatment of glaucoma. Polymorphic study of tropicamide is done by using solvents viz Chloroform, Dichloromethane, Isopropanol, Benzene, Acetone, Ethanol, Methanol, Tween 80, Povidone K30, PEG 4000 and Phosphate Buffer. Crystals of all the solvents were made with tropicamide out of which best stability of the compound was found with benzene, acetone, ethanol and methanol. Crystals were compared using various methods like Dissolution, DSC, XRD, and IR spectroscopic.
Palvi Sharma, Shivali Singla, Abhishek Soni, Priyakul Palia, Sachin Goyal
Research & Review: Drugs and Drugs Development, Volume 4, pp 13-28; https://doi.org/10.46610/rrddd.2022.v04i01.002

Abstract:
This review gives information about some new discovered imidazole derivatives and the activities of these imidazole derivatives. In this review, summarized imidazole derivative which have been proved to exhibit various pharmacological activities as antimicrobial, anti-inflammatory, anti-tubercular, anti-depressant, antiviral and analgesic. Many study reports have been generated in a short period of time due to the rapid development of novel compounds containing this nucleus. As a result, it appears that recent data is needed to understand the current state of the imidazole nucleus in medicinal chemistry research, with a focus on the numerous attempts to synthesis and investigate new structural prototypes with improved therapeutic activities.
Mohsina F. P., Aamir Quazi, Faheem I. P., Anuradha M., Mohammad Mukim, Abhinandan Patil
Research & Review: Drugs and Drugs Development, Volume 4, pp 1-12; https://doi.org/10.46610/rrddd.2022.v04i01.001

Abstract:
The plant Ichnocarpus frutescens belongs to family Apocynaceae, commonly known as ‘Black creeper’ (In Odia: Syamolota; Hindi: Kali-dudhi, Krishna sariva; Sanskrit: Syamalata, Sariva). It is native to India, China, Java, Ceylon, Southeast Asia, and northern Australia. It is a large, evergreen, woody climbing plant. In India, tribes used this plant as a substitute of Indian Sersaparilla (Hemidesmus indicus). Phytochemical investigation indicates that plant belong to various category viz. phytosterol, triterpenes, flavonoids and various other phenolic compounds. Pharmacological activities of different parts of the plant reported include anti-urolithiasis, hepatoprotective, antioxidant, analgesic, antipyretic, anti-inflammatory, antidiabetic, antihyperlipidemic and antitumor activity etc. The presented review article aims to highlight a brief and comparative data on botanical, ethnopharmacological, phytochemical & pharmacological standards of plant Ichnocarpus frutescens.  
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