Biomedicine and Chemical Sciences

Journal Information
EISSN : 2790-296X
Total articles ≅ 26

Latest articles in this journal

Mohammed G. A. Al-Khuzaie, , Ahmed Jalil Al-Safi
Biomedicine and Chemical Sciences, Volume 3, pp 193-206;

Isatin is a heterocyclic nitrogen compound that has attracted much interest in recent years due to its diverse biological and pharmacological activities. It can be used in many medical and biological applications, such as antidiabetic, antibiotic, and anticancer agents. The isatin molecule can also be prepared from different substrates by various methods, such as the methods of Sandmeyer, Stolle, Gassman, Meanwell and Hewawasam and others. On the other hand, the isatin molecule can undergo various chemical reactions, such as oxidation, Friedel-Crafts reaction, ring expansion, aldol condensation, and alkylation reactions. As a result of these reactions, several biologically useful biomolecules are formed, including 2-oxindoles, tryptanthrin, indirubins and others. Therefore, the aim of this review was to provide an overview of the synthetic methods of the isatin molecule and its derivatives and to examine the various chemical reactions it undergoes. In addition, a list of some of the recently documented biological activities of isatin derivatives was compiled, such as antidiabetic, antibacterial, anticancer, and other properties.
Ahmed Salim Shantah Al-Sadkhan, Dawood S. Ali, Salah Sh. Alluaibi
Biomedicine and Chemical Sciences, Volume 3, pp 110-116;

A total of 130 overweight Iraqi women with uncontrolled type 2 diabetes, the ages of the women ( 28 to 60) years, were divided into groups, group 5000 IU (65 women) as group A and control (65 women) as group B. were participants from The Specialized Center for Diabetes in Maysan Province and its related areas in the countryside and the city for this double-blind, randomized control trial (Maysan Province, Iraq). A placebo and 5000 IU of D3 daily were given to the participants for four months. Laboratory tests were conducted at baseline and four months to analyze serum levels. After four months of treatment, positive changes in total cholesterol, D3 levels, and LDL cholesterol. There was no statistically meaningful change in HDL and TG concentration, and there were no significant differences in age and place of residence. According to this study, vitamin D may help type 2 diabetics lower their total cholesterol and LDL concentrations.
Anaam Rasheed, Senan Albayati, Sarab Alazawi, Enas Zuhair, Mudeer Merza, Khalil Abid
Biomedicine and Chemical Sciences, Volume 3, pp 138-146;

A new metal-free macrocyclic Schiff base ligand bearing two metal cavities incorporated with two sets of N3O2 donor atoms derived from 2, 6-diaminopyridine and isatine was synthesized. The new ligand was used to prepare homo and hetero binuclear macrocyclic Schiff base complexes with Ni (II), Cu (II), ZrO (II) and Ba (II) metal ions. The ligand and metal complexes were characterized using Fourier transform infrared (FT-IR), UV–vis, mass spectroscopy, elemental analysis (CHN), thermo gravimetric analysis (TGA), magnetic susceptibility, and molar conductivity measurements. The DFT calculations using the B3LYP functional method have been applied to obtain the geometry and electronic properties of the ligand and its metal complexes to support the experimental data. To describe the reactivity of the title molecules, the HOMO and LUMO levels and Mulliken atomic charges were determined.
Yazi Abdullah Jassim
Biomedicine and Chemical Sciences, Volume 3, pp 160-163;

Antibiotic resistance occurs when microorganisms develop mechanisms that protect them from the effects of antibiotics. Resistant microorganisms are more difficult to treat, require higher doses or alternative therapies may be more toxic, as well as more expensive. Microorganisms that are able to resist many antibiotics are called multi-resistant. All kinds of microorganisms can develop this ability to resist; Fungi develop resistance against antifungals, viruses develop resistance against antivirals, protozoa develop resistance against protozoa, and bacteria develop resistance against antibiotics. Resistance arose naturally either through genetic mutations or through the transmission of resistance from one sex that has acquired it to another that has not yet acquired it, in particular. Accordingly, it is urgent to reduce the misuse of antibiotics by not using them only when they are really needed.
Mustafa M. Grafa, Hanan M. Ali
Biomedicine and Chemical Sciences, Volume 3, pp 168-177;

In this study, 2,5-dimethyl-4-((4-nitrobenzylidene) amino) phenol (A1), N,N'-([1,1'-biphenyl]-4,4'-diyl)bis(1-(2,4-dimethoxyphenyl)methanimine (A2) and 4,4'-(([1,1'-biphenyl]-4,4'-diylbis(azaneylylidene))bis (methaneylylidene))bis(2-methoxyphenol) (A3) were synthesised. Analytical studies were then carried on (A1), (A2) and (A3); the results of the solvent effect were displayed that the best solubility was in ethanol and DMSO of each, which is due to the fact that the effect of the dielectric constant is the main factor that can control the shift of the absorption beaks. The results were also indicated, that there is a slight deviation from the linear relationship in (A3) that may have related to the hydrogen bond between this base and the solvent. However, the results of the pH effect of (A1), (A2) and (A3) in a range of buffer solution were gave two isopiestic points just in (A3). Due to the ionization constant (pKa) and the protonation constant (pKp) were calculated by using the half height method. Further, the results were indicated the existence of the equilibrium schemes of which displays the suggested ionization of (A3) in acidic and basic medium. Further, the effect of the prepared Schiff bases (A1, A2, and A3) were studied on breast cancer cells type MCF-7 using five different concentrations of each. The results were showed high inhibition activities of each especially at high concentration, due recommend these bases as novel anti-cancer drugs.
Zahraa A. N. Al-Yassiry, Basheer Al-Alwani
Biomedicine and Chemical Sciences, Volume 3, pp 132-137;

Various molecular methods could be utilized in order to investigate botanical diversity. Arbitrary primed DNA, variable number of tandem repeats (VNTR), Restriction fragment length polymorphism (RFLP), polymerase chain reaction (PCR) sequencing, amplified fragment length polymorphism (AFLP), and sequence-tagged simple sequence repeats (SSRs) are all briefly reviewed. DNA-based approaches have recently been proved to be useful for crucial tasks, like specimen identification and targeted screening for expected or known invaders, according to a recent study. Prior to more ambitious applications, as extensive surveys of complex environmental samples and propagule pressure prediction, could be conducted, considerable technological obstacles should be solved. The aim of the current review was to estimate the molecular techniques used for assessing the genetic diversity of plants. The degree of variation among the plant species based on genetics is described as the genetic diversity of plants, evaluating the possible value regarding the current invasive species monitoring methods.
FaheemA Jabbar, Azhar A. Al-Attraqchi, Dina Nabeel Alkhayyat
Biomedicine and Chemical Sciences, Volume 3, pp 126-131;

Opportunistic fungal infections due to the immune- compromised status of renal transplant patients are related to high rates of morbidity and mortality regardless of their minor incidence. Delayed in identification of invasive fungal infections (IFIs), will lead to delayed treatment and results in high mortality in those populations. The study aimed to assess the frequency of invasive fungal infection in kidney transplant recipients by conventional and molecular methods. This study included 100 kidney transplant recipients (KTR) (75 males, and 25 females), collected from the Centre of Kidney Diseases and Transplantation in the Medical City of Baghdad. Blood samples were collected during the period from June 2018 to April 2019. Twenty one out of 100 renal-transplanted patients were infected with pathogenic fungi, four of the patients were females and 17 were males. There is an observation of a high incidence of fungemia in patients with the abnormal value of blood urea according to PCR and culture results. Referring to fungal isolates the most prevalent was Saccharomyces cerevisiae, which account for 19 isolates out of 21 the other two isolates were Zygosaccharomyces rouxii and Aspergillus flavus. The results of the current study show significant correlation between PCR and culture methods at (P<0.0009).
Abdullah H. Al-Saadoon, , Luma .H. Ali,
Biomedicine and Chemical Sciences, Volume 3, pp 117-125;

Soil is one of the favorable habitat for microorganism. It considered being the home of wide range of them in particularly, bacteria and fungi. Southern Iraq is characterized by a multiplicity of ecosystem, which include desert, agricultural and marine areas, each of which has special composition that differs from the neighboring system, whether in terms of vegetation or various environmental factors. This in diversity, in turn, may lead to microbial diversity that can be used in different biotechnologies. Regarding that little is known about yeast diversity in such habitats, and therefore the current study aims to assess the yeast community in soil and sediments samples from Basrah and Dhi-Qar provinces, Southern Iraq. Thirty-one species belong to 19 genera were encountered. The isolated species consist of 16 species of Ascomycota and 15 species of Basidiomycota. The soil of Basrah and Dhi-Qar support the growth of diverse species belonged to the genera Aureobasidium, Cutaneotrichosporon, Debaryomyces, Filobasidium Geotrichum, Hanseniaspora, Lodderomyces, Meyerozyma, Symmetrospora, Torulaspora, Vishniacozyma, Pichia, Yarrowia, Cystobasidium, Galactomyces, Rhodotorula, Wickerhamomyces, Candida and Naganishia. One hundred and twelve fungal isolates were identified using the conventional methods depending on morphological characteristics. CHROMagar candida was used as differential culture medium. Iodine stain was used to differentiate ascospores and basidiospores. In addition biochemical method represented by VITEK was used as well as molecular identification. This study represents the first report of occurrence of yeast species in soil and surface sediment samples from Basrah and Dhi-Qar provinces, Southern, Iraq, with effect of some ecological factors on isolation yeast from different location.
May Jaleel Abed, Ahmed Ebrahim Hamzah, Kasim Kadhim Alasedi
Biomedicine and Chemical Sciences, Volume 3, pp 178-192;

Six derivatives of novel triazoles were produced from some substituted benzoic acid with thiocarbazide via method of grinding. The produced Chemicals were described via 1HNMR, IR, and 13CNMR spectra examinations. Produced derivatives of C2H3N3 were examined and assessed as reducing of corrosion in 0.5 M HCl for low-C steel utilizing procedure of losing weight. It was noticed that such chemicals had an encouraging act as reducer counter to mild steel corrosion of in solution being acidic. Reducing of maximum action was assessed at various concentrations and temperature of effector. Competence of corrosion reducer surpassed 96%. The exceptional action was due to inhibitor films adsorption development on surfacing steel. Reducing adsorption on surface of steel tracked Langmuir adsorption isotherm (LAI). The results were long-established BY theoretical calculations of quantum chemistry.
Muhanad T. Almayyahi, Basil A. Saleh, Baqer A. Almayyahi
Biomedicine and Chemical Sciences, Volume 3, pp 147-159;

Nine copolyesters were prepared from a dicarboxylic acid, curcumin analogues (monocarbonyl) and phenophthalene dye in the mole ratio of 2:1:1 by direct polycondensation using triethylamine (Et3N) as the condensation agent. The dicarboxylic used is 2,6-Pyridine dicarbonyl dichloride acid. The curcumin analogues were prepared by acid catalyzed Aldol condensation reaction. These copolyesters were characterized by FT-IR. The fluorescence of the synthesized copolyesters was also investigated. Furthermore, Thermo gravimetric analysis (TGA) was used to investigate the thermal stability of these copolymers.
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