Medical Research

Journal Information
ISSN / EISSN : 2664-0333 / 2664-0341
Published by: Creative Publishing Co., Limited (10.6913)
Total articles ≅ 55
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Jianfang Zhang, Zhiming Luo, Chuyu Xie, Hujie Zhang
Published: 30 June 2022
Journal: Medical Research
Medical Research, Volume 4, pp 44-51; https://doi.org/10.6913/mrhk.040206

Abstract:
Carbon dots (CDs) were synthesized via a simple method and applied in bioimaging. The CDs display excitation-independent fluorescence emission and exhibit upconversion PL, providing further tissue penetration and greater sensitivity as the effect of the autofluorescence of biological bodies is minimized and cellular imaging. This is the first time that excitation-independent carbon dots is prepared via a truly facile approach without the need of external heating or additional energy input. These results indicate that the CDs have excellent potential to be applied in biomedical and clinical analysis.
Chuyu Xie, Hujie Zhang, Fei Yu, Wenfeng Huang, Yaoliang Zhou, Zhifeng Mo, Xiaoxing Liao
Published: 30 June 2022
Journal: Medical Research
Medical Research, Volume 4, pp 1-7; https://doi.org/10.6913/mrhk.040201

Abstract:
[Objective] Sudden cardiac death (SCD) caused by unexpected cardiovascular arrest remains a major public health threat globally. Cardiopulmonary resuscitation (CPR) is a basic but critical first aid skill to rescue patients with sudden cardiac arrest. This study aimed to ascertain whether the mind mapping technique, a note-taking and graphic thinking tool, could improve the learning of CPR among medical interns. [Methods] A total of 79 medical interns rotating in the emergency department in our center were selected as research participants. They were randomly divided into the control group (n=40) and the experimental group (n=39). The control group was trained with traditional PowerPoint (PPT) slide courseware combined with practical operations, while the experimental group was trained with mind mapping technique on the basis of traditional PPT courseware combined with practical operations. The theoretical test, operational assessment, and the survey regarding the satisfaction with the training were conducted between the two groups of interns after training. [Results] Although the interns in both groups mastered the CPR technique successfully with theoretical and operational assessment scores >90 (out of 100), the experimental group performed significantly better in both theoretical tests (score: 96.13±2.47 vs 93.71±4.48, p=0.0041) and operational assessment (score: 94.82±3.22 vs 91.32±3.46, p<0.0001). Moreover, all interns (100%) in the experimental group were satisfied with the CPR training experience, while only 75% of the interns in the control group were satisfied with the training. [Conclusions] Mind maps as a supplementary teaching tool could facilitate CPR learning for medical interns and improve their learning interest.
Junhui Sun, Liqiang Zhou, Siyuan Huang, Zhaofeng Li, Yi Qin
Published: 30 June 2022
Journal: Medical Research
Medical Research, Volume 4, pp 66-77; https://doi.org/10.6913/mrhk.040210

Abstract:
Lumbar degenerative disease (LDD) refers to the normal strain of the body involving lumbar bone, ligament, intervertebral disc, thereby protruding lumbar intervertebral disc, slippage, spinal stenosis and other lesions. Lumbar fusion surgery has been proved to be an effective strategy for the treatment of LDD. At present, a variety of fusion methods such as anterior and posterior have been reported. This article aims to review and discuss the reported strategies of fusion surgery for LDD and related biomechanical studies and analyze the development and significance of the finite element method (FEM) in lumbar biomechanics. To investigate the influence of different surgical strategies on lumbar spine biomechanics from the perspective of biomechanics and to provide a reference for selecting clinical surgical strategies.
Ping Xiao, Kaiyin Chen, Yunxiao Zhu
Published: 30 June 2022
Journal: Medical Research
Medical Research, Volume 4, pp 44-51; https://doi.org/10.6913/mrhk.040207

Abstract:
[Objective] To investigate the correlation between serum levels of homocysteine (Hcy) and cystatin C (CysC), a sensitive marker of renal function, in patients with H-type hypertension. [Methods] A total of 857 patients with essential hypertension without moderate to severe renal impairment (estimated glomerular filtration rate ≥ 60 ml/(min-1.73 m2) by Modification of Diet in Renal Disease equation) visited the Seventh Affiliated Hospital of Sun Yat-sen University from May 2018 to May 2020 were selected as the research subjects. The observation group (n = 635) consisted of patients with H-type hypertension (essential hypertension with Hcy ≥ 10 mmol/l) and the control group (n = 222) consisted of patients with non-H-type hypertension (essential hypertension with Hcy < 10 mmol/l). Multivariate logistic regression analysis, curve fitting, and threshold analysis were used to evaluate the correlation between elevated CysC and serum Hcy levels. [Results]CysC in observation group was significantly higher than that in control group (0.96 ± 0.160 vs 0.84 ± 0.13 mmol/l; p < 0.001). Multivariate logistic regression analysis, curve fitting, and threshold analysis showed that there was a significant difference in the risk of CysC elevation between Hcy levels at 10-25 mmol/L and Hcy levels below 10 mmol/L; there was no significant difference in the risk of CysC elevation between Hcy levels above 25 mmol/L and Hcy levels below 10 mmol/L. The inflection point of Hcy was 15.23 mmol/L, and when Hcy was < 15.23 mmol/L, the probability of CysC elevation increased by 27\% for each 1 mmol/L increase in Hcy (OR 1.27, 95\% Cl: 1.12, 1.44; P = 0.0002). When Hcy was > 15.23 mmol/l, the probability of CysC elevation was reduced by 4\% for each 1 mmol/l increase in Hcy (OR 0.96, 95\% Cl: 0.92, 1.01; P = 0.1085). [Conclusions] The risk of CysC in patients with H-type hypertension is higher than that in patients with non-H-type hypertension when Hcy is between 10-25 mmol/L; and the probability of cystatin C elevation is the highest when Hcy is at 15.23 mmol/L.
Pei-Ying Liu, Yan Lin, Li-Li Shu, Mei-Xue Zhang, Meng-Meng Wang, Dong-Mei Wu, Juan Xiao
Published: 30 June 2022
Journal: Medical Research
Medical Research, Volume 4, pp 52-58; https://doi.org/10.6913/mrhk.040208

Abstract:
[Objective] In this study, we aimed to explore the effect of educational micro movies and practical experience (nurses as simulated patients) in improving the quality of peri-operative stretcher transportation service in the hospital. [Methods] From November to December 2021, 414 nurses from 18 departments of the Surgery Department of Guangzhou Women and Children's Medical Center participated in this practical study. Each nurse experienced the perioperative stretcher transportation service in the role of a patient, and experienced the whole process of being transferred from the ward to the operating room by the nursing staff, and then back to the original department. The whole process was recorded with photos and videos, and educational micro movies were made by department as a unit. [Results] Through this practice project, 17 disadvantageous factors (in 5 categories) affecting the quality of stretcher transportation service were summarized and 26 improvement measures were formulated. A total of 17 educational micro movies were released online by 18 departments; as of the end of December 2021, these movies have reached 113,994 views. 84.62% of nurses were satisfied or very satisfied with this practice project, and they believed that this new approach could help improve the quality of perioperative stretcher transportation service. [Conclusions] In this practical study, by allowing nurses to discover the deficiencies through fitting in patients’ role, the standard operation procedure (SOP) for peri-operative stretcher transportation service was revised and improved.
Lei Peng, Ling Jin, Xincheng Ma
Published: 30 June 2022
Journal: Medical Research
Medical Research, Volume 4, pp 15-25; https://doi.org/10.6913/mrhk.040203

Abstract:
[Objective] Junior nurses’ perceived risk level may affect their career satisfaction and performances. This study sought to investigate the current situation of risk perception level of junior nurses with undergraduate degrees and to determine its influencing factors, with the aim to provide a reference for nursing managers to carry out targeted training and education for junior nurses. [Methods] A total of 484 junior nurses with undergraduate degrees from five tertiary hospitals in Guangdong Province were selected by the convenience sampling method as the research participants. The general information questionnaire, risk perception questionnaire and the Chinese version of the Positive and Negative Affect Schedule (PANAS) scale were used for the survey. [Results] The enrolled junior nurses scored 85.84±13.56 (Full score was 100) on the risk perception survey. Working years, positive and negative affect, gender, and personality characteristics were the main influencing factors for junior nurses’ risk perception levels (P<0.05). [Conclusions] Junior nurses' risk perception was at a moderate and acceptable level. However, their risk perception was higher in dimensions such as physical function, occupational exposure, and time. Therefore, nursing managers should pay attention to high-risk perception items, and targeted measures should be taken according to different characteristics of nurses to improve their ability to correctly recognize risks and eliminate negative emotions in order to improve the quality of nursing services.
Tingwei Wang, Jie Zhong, Lili Zong
Published: 30 June 2022
Journal: Medical Research
Medical Research, Volume 4, pp 26-30; https://doi.org/10.6913/mrhk.040204

Abstract:
[Objective] Polycystic ovary syndrome (PCOS), a common female health condition caused by a hormonal imbalance due to the ovaries producing excess male hormones, is also considered a chronic endocrine-metabolic syndrome. According to the traditional Chinese medicine (TCM) theory, multiple factors including insufficiency of kidney and liver as well as phlegm dampness may result in PCOS. This study aimed to investigate the distribution pattern of TCM syndrome types in patients with PCOS, and to determine the glucose metabolism status among these patients. [Methods] A total of 60 patients diagnosed with PCOS in our center were enrolled in this study. These patients were classified into three groups based on their TCM syndrome types, including phlegm dampness syndrome, liver stagnation syndrome, and kidney insufficiency syndrome. A uniformly formulated basic information sheet was collected, and all of them underwent glucose tolerance test (OGTT). The correlations of body mass index (BMI), waist to hip ratio (WHR), and glucose metabolism in patients with different syndromes were compared. [Results] The patients with phlegm dampness syndrome type (n=32) were the most among these 60 patients with PCOS, accounting for 53.33%, followed by liver stagnation syndrome (n=18; 30%) and kidney insufficiency syndrome (n=10; 16.67%). The BMI and WHR of patients with phlegm dampness syndrome were higher than those with liver stagnation syndrome and kidney insufficiency syndrome (P0.05). [Conclusions] The main TCM syndrome type in patients with PCOS is phlegm dampness syndrome, which was linked to obesity and abdominal obesity.
Xiao Ye, Li Ma, Yutao Qiu, Jipeng Yang
Published: 30 June 2022
Journal: Medical Research
Medical Research, Volume 4, pp 59-65; https://doi.org/10.6913/mrhk.040209

Abstract:
[Objective] This study aimed to investigate current issues, root causes, and improvement measures of the main diagnostic codes on the homepage of a hospital's inpatient medical records, and to improve the accuracy of the hospital's main diagnostic codes.[Methods]A retrospective analysis was carried out on the homepage data of inpatient medical records in a hospital. After implementing the quality control of medical record coding, we compared and analyzed 1000 medical records before the intervention (March 1 to June 30, 2020) and 1000 medical records after the intervention (March 1 to June 30, 2021). The accuracy of the homepage data of the medical records was compared and the quality control efficacy after the intervention was evaluated.[Results] Following the intervention, the number of major diagnostic errors on the homepage of medical records decreased by 84% (from 38 cases per 1000 to 6 cases per 1000, p<0.05). Among them, the main diagnosis error was reduced from 6 cases to 1 case, the main diagnosis selection error was reduced from 5 cases to 2 cases, the ambiguous (QY) medical records were reduced from 19 cases to 2 cases, and the medical records with codes not merged were reduced from 9 cases to 1 case. According to the analysis of influencing factors, after the intervention measures were taken, the filling errors by physicians decreased from 17 cases to 2 cases, the errors by coders decreased from 12 cases to 2 cases, and the errors from information management decreased from 9 cases to 2 cases.[Conclusions] After the intervention, the number of errors in filling by physicians, coding by coders, and information management on the homepage of medical records decreased significantly. In addition, the accuracy of the main diagnostic codes on the homepage has been greatly improved, which helps ensure the reliability of information statistics and effectively improves the quality and safety of medical care.
Tingwei Wang, Lili Zong, Jie Zhong, Kaiyin Chen Chen
Published: 30 June 2022
Journal: Medical Research
Medical Research, Volume 4, pp 31-36; https://doi.org/10.6913/mrhk.040205

Abstract:
Oblique vaginal septum syndrome (OVSS) is a rare congenital disorder characterized by uterus didelphys, hemivaginal septum, and unilateral renal agenesis. Its clinical characteristics vary among different patients. Herein we report a case of OVSS with difficulty in defecation as the initial symptom and diagnosed with ultrasound and laparoscopic exploration. This 13-year-old girl was admitted to our hospital with the complaint of difficulty in defecation for more than 1 month and difficulty in urination for 6 days. Her ultrasound test showed that the left kidney was not displayed, and the right kidney was compensatory enlargement. A giant cystic-solid mass (110 mm × 96 mm × 87 mm) was seen in the pelvic cavity. Under laparoscopy, a huge mass was seen in the abdominal cavity. The surface resembled the seromuscular layer of the uterus. A uterine organ was seen on both sides of the tumor, and both fallopian tubes and ovaries were connected. The size of the right uterus was about 3 cm × 2 cm. The right fallopian tube and ovary were normal in appearance. The left uterus was enlarged (about 6 cm x 5 cm). The left fallopian tube was enlarged and contained a large amount of brown blood stains, and blood stains were seen flowing out from the umbrella end. The hysteroscopic incision and repair surgery were then performed. Most patients with OVSS presented with dysmenorrhea, abdominal pain, pelvic mass, and foul mucopurulent discharge, while in this case, difficulty in defecation was the initial symptom. Thus, this case report provided evidence supporting the heterogeneity of this disorder.
Yehong Huang
Published: 30 June 2022
Journal: Medical Research
Medical Research, Volume 4, pp 8-14; https://doi.org/10.6913/mrhk.040202

Abstract:
Cervical cancer is one of the most common malignant tumors in women; hence the world has been working to improve the effective screening and prevention of cervical cancer. Colposcopy plays a central role in cervical cancer prevention, but its accuracy and reproducibility are still limited. The use of deep learning in the field of medical images allows more researchers as well as to explore the application of deep learning in colposcopy image-assisted diagnosis. In this paper, we summarize the research status of this field and propose the current shortcomings and improvement directions this research field.
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