Dental Journal (Majalah Kedokteran Gigi)

Journal Information
ISSN / EISSN : 1978-3728 / 2442-9740
Published by: Universitas Airlangga (10.20473)
Total articles ≅ 735
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Latest articles in this journal

Moehamad Orliando Roeslan, Gabriella Tasha
Dental Journal (Majalah Kedokteran Gigi), Volume 54, pp 150-154;

Background: Squamous cell carcinoma (SCC) is classified as the most common type of oral cancer up to 90% of all malignant neoplasm in the oral cavity. Currently, the only treatments for SCC are surgery and/or radiation or chemotherapy, which can cause various side effects. Cogon grass leaves (Imperata cylindrica) have been considered an alternative cancer treatment that may reduce side effects. Imperata cylindrica (I. cylindrica) leaf extract can inhibit cancer cell proliferation and migration by withholding the cell cycle in the gap 1/synthesis (G1/S) and gap 2/mitosis (G2/M) phases. Therefore, the levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) is decreased and cancer is not progressing. Purpose: The study aims to determine the effect of I. cylindrica leaf extract on the proliferation and migration of human oral squamous carcinoma-3 (HSC-3) cell lines. Methods: This in vitro experimental study was conducted with nine study groups. The treatment group was divided into seven concentrations—640 ppm, 320 ppm, 160 ppm, 80 ppm, 40 ppm, 20 ppm and 10 ppm. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium-bromide (MTT) assay and scratch assay were carried out to assess the effect of I. cylindrica leaf extract on HSC-3 cell proliferation and migration. Results: Ethanol extract of I. cylindrica has a significant effect compared to the negative control towards the proliferation and migration of HSC-3 cells. Conclusion: This study shows that I. cylindrica ethanol leaf extract can inhibit proliferation and migration of HSC-3 cells.
Dwi Setianingtyas, N. Nafiah, Cane Lukisari, Paulus Budi Teguh, Felicia Eda Haryanto, Erni Marlina
Dental Journal (Majalah Kedokteran Gigi), Volume 54, pp 155-159;

Background: In 2019, a viral disease spread from Wuhan, Hubei Province in China. The disease was caused by severe acute respiratory syndrome related to coronavirus 2 (SARS-CoV-2 virus), which was named by the Coronavirus Study Group of the International Committee on Taxonomy of Viruses. Purpose: This article reports the multi-discipline treatment of Covid tongue and exfoliative cheilitis with a main diagnosis of bilateral pneumonia caused by SARS-CoV-2 infection. Case: A female patient, 70 years old was referred with a diagnosis of bilateral pneumonia by a pulmonologist. She complained of painful wounds all over her mouth. An intraoral clinical examination revealed white-thick lesion and multiple ulcerations, whilst an extraoral exam for exfoliative dermatitis has not been described. The working diagnosis was Covid tongue mixed with exfoliative cheilitis. Case management: The procedure was performed by teledentistry and direct visits to implement oral health care by asepsis, debridement and the application of Oxygene gel. Conclusion: The lesion was treated successfully due to the multidisciplinary approaches by an internist and pulmonologist by implementing integrated knowledge and was supported hugely by patient cooperation.
Nila Sari, Abil Kurdi, Bambang Agustono Satmoko Tumali, Muhammad Dimas Aditya Ari
Dental Journal (Majalah Kedokteran Gigi), Volume 54, pp 160-164;

Background: Dental problems often lead to missing teeth. After tooth extraction, the alveolar bone will undergo a healing phase, and this will cause some vertical and horizontal resorption. Immediate implant placement can shorten treatment time and preserve the rest of the alveolar bone. Purpose: The purpose of this study is to present a case of oral function, equilibrium and aesthetic rehabilitation using immediate implant placement. Case: A male patient aged 31 came to Dental Hospital Universitas Airlangga with a fractured anterior tooth. The tooth had fractured two weeks before he came to the hospital, and he wanted to improve his appearance. Case management: The mandibular incisor was fractured, and its residual root remained. The treatment plan was to undertake an immediate implant placement. The type of implant chosen was a bone level tapered implant SC roxolid® SLA Ø 2.9 mm and 10 mm long. Surgery was performed in two stages. The first stage was to extract the residual root, position the implant and apply the bone graft. The second stage was to position the healing abutment. A crown impression was made using the closed tray technique. The crown was cemented to the abutment. Conclusion: Immediate implant placement is an aesthetic means of rehabilitating a missing tooth, such as an anterior mandibular tooth.
Sri Kunarti, Widya Saraswati, Dur Muhammad Lashari, Nadhifa Salma, Tasya Nafatila
Dental Journal (Majalah Kedokteran Gigi), Volume 54, pp 165-168;

Background: Dental caries is a multifactorial disease indicated by the progressive demineralisation process of dental tissue. It is caused by an imbalance between the remineralisation and demineralisation processes. The focus of caries management is on prevention. Providing materials that can induce remineralisation is one management of caries prevention. Various materials have been or are being researched, such as casein phosphopeptide amorphous calcium phosphate (CPP–ACP), tricalcium phosphate (fTCP), bioactive glass (BAG), and nanotechnologies such as nano-hydroxyapatite (n-HAP) and silver nano fluorine (NSF). Purpose: This study aims to review the development of enamel remineralisation inducing materials as a newer approach in caries prevention. Review: Various ingredients have been shown to increase enamel remineralisation through different mechanisms in preventing the development of carious lesions. Conclusion: CPP–ACP, fTCP, BAG, n-HAP, and NSF can induce enamel remineralisation as caries prevention agents. n-HAP and NSF are the most effective agents to enhance enamel remineralisation to prevent caries.
Salsabila Qotrunnada, Dina Z. Ummah, Mei Syafriadi
Dental Journal (Majalah Kedokteran Gigi), Volume 54, pp 137-142;

Background: Tooth eruption begins after crown and root formation and may be delayed by gestational diabetes mellitus. Metformin can control blood glucose levels through gluconeogenesis inhibition, and consuming thymoquinone for diabetic treatment will regenerate pancreatic β cells and reduce oxidative stress. Purpose: The objective of this study is to compare the tooth eruption in rats that were born with diabetes and are being treated with either metformin or thymoquinone. Methods: This study used 48 Wistar rats (Rattus norvegicus L.), and the rat sample was divided into four groups, including rats who were born from healthy mothers, rats who were born from untreated diabetic mothers, rats who were born from diabetic mothers that were treated with metformin and rats who were born from diabetic mothers that were treated with thymoquinone. Diabetes was induced by intraperitoneal injection of a single dose of streptozotocin (40 mg/kg BB). Each rat sample was taken with simple random sampling from different mothers, and body weight, blood glucose levels and levels of tooth eruption were recorded. Eruptions of the maxillary right first molar were measured from the cusp of the tooth to the alveolar epithelial lining. Results: Based on the measurements of tooth eruption, it was found that groups A, C and D were closer to mucosa on day 1, 7 and 14 than group B. Based on statistical analysis, there were significant differences (p = 0.03) between group B and groups C and D. Conclusions: Rats born from untreated diabetic mothers have more delays in tooth eruption than those born from diabetic mothers who are treated with metformin and thymoquinone. Thymoquinone has the potential to be an alternative to metformin because it has been shown to be similarly effective.
Yona Pricilia Anggi Siregar, C. Christnawati, Darmawan Soetantyo
Dental Journal (Majalah Kedokteran Gigi), Volume 54, pp 143-149;

Background: Mastication patterns due to malocclusion with unilateral posterior crossbite may permanently change. Purpose: This study aimed to examine the effect of malocclusion with unilateral posterior crossbite of the superficial masseter and anterior temporal muscles on the crossbite and non-crossbite sides during mastication. Methods: Thirty subjects (8 males and 22 females) between the ages of 17 and 30 years who were students of the 2017–2019 Dentistry and Dental Hygiene Study Program, Faculty of Dentistry, UGM and who had at least two posterior teeth with unilateral posterior crossbite were divided into 10 subjects with Angle’s class I, 10 subjects with class II and 10 subjects with class III malocclusions. The amplitude of the superficial masseter and temporal anterior muscles was performed during mastication using surface electromyography (sEMG). The mean difference between the groups of malocclusion on the crossbite and non-crossbite sides of the superficial masseter and temporal anterior was analysed by a two-way analysis of variance (ANOVA). Results: The results indicated a difference in amplitude mean between the malocclusion types on the crossbite sides and non-crossbite sides of the superficial masseter and temporal anterior muscles (p<0.05). This study confirmed there was a decrease in superficial masseter and anterior temporal muscle activity on the crossbite side rather than in the non-crossbite side in Angle’s class I and class II. However, there was an increase in activity of the superficial masseter and anterior temporal muscles on the crossbite side for class III. Conclusion: Malocclusion with unilateral posterior crossbite affects masticatory activity of the superficial masseter and temporal anterior muscles on the crossbite side.
Eha Renwi Astuti, Hutojo Djajakusuma, Indeswati Diyatri, Nastiti Faradilla Ramadhani
Dental Journal (Majalah Kedokteran Gigi), Volume 54, pp 128-131;

Background: Panoramic and cephalometric radiography is very important for diagnosis, treatment plan, and evaluation of orthodontic treatment results. Panoramic and cephalometric radiography are frequently performed at the same time, causing DNA damage and chromosome aberration. Purpose: This study aims to analyse the effect of X-ray exposure in panoramic and cephalometric radiography on micronuclei cell numbers. Methods: Laboratory-based analytical study with 60 healthy-male Wistar rats weighing 200–300 grams divided into 6 treatment groups (n=10). The control group: without radiographic exposure, the treatment group 2: using panoramic radiographic exposure followed by cephalometric, and the treatment group 3: using panoramic radiographic exposure and 24 hours later performed cephalometric radiographic. The unit of analysis was the polychromatic erythrocytes of mice cell, were examined 24 hours and 48 hours after irradiation had been finished. The polychromatic erythrocytes were examined using May-Gruenwald-Giemsa staining and 100x magnification under a microscope with 2000 cells per view. Data obtained were analysed using the SPSS 20 version software. The mean and standard deviations were calculated for each clinical parameter, and a one‐way ANOVA statistical test of significance was used. Statistical significance was set at p<0.05. Results: The analysis showed a significant increase (p<0.05) in the number of micronucleus in groups that used panoramic radiographic exposure followed by cephalometric. Conclusion: X-ray radiation can increase the number of micronucleus in polychromatic erythrocyte cells in rats.
Hilda Fitria Lubis, Maureen Olivia
Dental Journal (Majalah Kedokteran Gigi), Volume 54, pp 132-136;

Background: Soft tissue analysis is essential in treatment planning to ensure proportional, balanced, and harmonious soft tissue at the end of treatment. Several factors influence the variations, such as age and gender. Soft tissue profile analysis is usually studied from a lateral view. Purpose: The study aimed to determine whether there were differences in the average values of linear and angular measurement of the soft tissue profiles of the middle and lower third of the face between Chinese males and females high school students using lateral photometry. Methods: The samples were 100 lateral photographs (50 male and 50 female) of Chinese high school students at W.R. Supratman 1 and 2 in Medan. All samples were collected based on the inclusion and exclusion criteria obtained from secondary data. The linear and angular measurements were measured using Software Corel Draw 2019 and analysed statistically using an independent t-test and the Mann-Whitney test. Results: The inferior facial third, length of the lower lip, and prominence of the upper lip were, on average, greater in males, whereas in the prominence of pogonion, nasolabial angles, and nasofrontal angles were greater, on average, for females. Conclusion: There were significant gender differences in Chinese high school students in the inferior facial third, length of the lower lip, prominence of the upper lip, nasolabial angle, and nasofrontal angle, whereas there is no significant difference between genders in the prominence of the pogonion.
Pratiwi Soesilawati, Ester Arijani Rachmat, Ira Arundina, Nita Naomi
Dental Journal (Majalah Kedokteran Gigi), Volume 54, pp 124-127;

Background: Research has proved that Aloe vera has anti-inflammatory, anti-bacterial, and immunomodulator properties that can accelerate the healing process. These properties could be beneficial in the tooth extraction wound-healing process. Neutrophils are the first inflammatory cells to invade and are the predominant cell markers in the wound for 24 hours after injury. Polymorphonuclear leukocytes (PMN) provide initial protection against micro-organisms, as they engulf and digest foreign bodies. Purpose: The aim of this study was to prove the effect of Aloe vera 90% gel application on the PMN count in the healing process of Cavia cobaya following tooth extraction. Methods: This laboratory experimental research was done using Post-Test Only Control Group Design. The lower incisive of twelve male Cavia cobayas were extracted then divided into four groups. Group P1 and P3 had 90% Aloe vera gel applied into the socket and sutured; group K1 and K3, received no 90% Aloe vera gel application and acted as controls. Samples from group P1 and K1 were terminated and had their mandibula taken one day after tooth extraction, and those from group P3 and K3 were terminated after three days. Tissues were then processed into histology slides, and PMN cells were counted. Results: There were significant differences in the PMN count between groups K1, P1, and K3 compared with P3 (p < 0.05). Higher PMN count was shown on the group containing Aloe vera 90% gel compared with control group, both on day one and three after tooth extraction. Conclusion: Aloe vera 90% gel can increase the PMN count in the inflammation phase of the tooth extraction wound-healing process.
Michael Josef Kridanto Kamadjaja, Alya Nisrina Sajidah Gatia, Agtadilla Novitananda, Lintang Maudina, Harry Laksono, Agus Dahlan, Bambang Agustono Satmoko Tumali, Muhammad Dimas Aditya Ari
Dental Journal (Majalah Kedokteran Gigi), Volume 54, pp 119-123;

Background: After tooth extraction, the socket leaves a defect on the alveolar bone. The administration of shell crab-derived hydroxyapatite maintains bone dimensions that are important for achieving successful prosthodontic treatment. Purpose: The aim of the study was to determine the osteogenic properties, such as the number of osteoclasts, osteoblasts and osteocytes, after the application of hydroxyapatite-based shell crab in the post-extraction sockets of Wistar rats. Methods: There were two groups: the control group (K) and the treatment group (T). Wistar rats were randomly divided into control and treatment groups. After tooth extraction, hydroxyapatite gel derived from Portunus pelagicus shells was applied to the tooth sockets of Wistar rats. Observations and calculations of osteoclasts, osteoblasts and osteocytes were carried out on the 14th and 28th days under a light microscope with 400 times magnification. Statistical analysis was performed using one-way ANOVA. Results: There was a significant difference (p<0.05) between the K14 and P14 groups, K28 and P28 groups, K14 and K28 groups, and P14 and P28 groups. The results indicated that there were significant differences between groups of variables. Conclusion: The application of shell crab-derived hydroxyapatite (Portunus pelagicus) was able to decrease the number of osteoclasts and increase the number of osteoblasts and osteocytes.
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