International Journal of Organic Chemistry

Journal Information
ISSN / EISSN : 21614687 / 21614695
Current Publisher: Scientific Research Publishing, Inc, (10.4236)
Total articles ≅ 308
Archived in
SHERPA/ROMEO
Filter:

Latest articles in this journal

Olusegun B. Olubanwo, Arianna Kazez, Daniel W. Carney, Jason K. Sello
International Journal of Organic Chemistry, Volume 9, pp 142-162; doi:10.4236/ijoc.2019.93013

Abstract:A new class of potential antibacterial agents has been synthesized on a new molecular scaffold of cyclohexane carboxylate. We have tagged this new class of compounds TACCs (Trisubstituted Aryl Cyclohexanecarboxylate). These new molecules are structural analogues of an Activators of Self-Compartmentalizing Proteases 4 and 5 (ACP 4 and 5), and were synthesized to circumvent the drug-like property (drug-ability) challenges and liability noted in ACP 4 and 5. A pseudo-Robinson annulation protocol was used to furnish this new class of potential antibiotics. Structure-activity relationship (SAR) study was done to identify the pharmacophore(s) in this molecular scaffold. A selection of these compounds was used in our preliminary antibacterial inhibitory activities’ studies on Bacillus mycoides and Bacillus subtilis. These preliminary studies show that the TACCs exhibited equal, and in some cases better, antibacterial activity than ACP 4 and 5.
Abdullah Taha, Mahmood Amani
International Journal of Organic Chemistry, Volume 9, pp 130-141; doi:10.4236/ijoc.2019.93012

Abstract:Oil and gas operations depend heavily on water in many different aspects. Water is present wherever there is hydrocarbon production. It is produced along with the hydrocarbons and helps in mobilizing them. It is also injected into the reservoirs to aid in mobilizing the hydrocarbons, maintain the pressure and increase the recovery of the development project. With water presence, some serious problems occur such as scaling. Scaling is a well-known problematic precipitation caused mainly due to mixing of two incompatible fluids, changes in temperature and pressure conditions and disturbance to thermodynamics and kinetics of reservoir fluids. They can be found at any point of the operations starting down at the formation up to the surface tanks. Scales are directly responsible for compromising the economics and safety of development projects. This review paper is going to include a recap of the importance of water in the oil and gas industry, then review the different types of scales as well as their properties including carbonate and sulfate scales. After that, famous scales from each type is going to be reviewed as well as their properties and precipitation conditions such as Calcium Carbonate CaCO3, Calcium Sulfate CaSO4, Barium Sulfate BaSO4 and Strontium Sulfate SrSO4. Moreover, common practices and precautions steps in the industry are going to be reviewed as well. Finally, the paper presents the common practices used by the operators for scale removal.
Cosmas O. Okoro, Mumiye A. Ogunwale, Abiodun S. Oyedele
International Journal of Organic Chemistry, Volume 9, pp 121-129; doi:10.4236/ijoc.2019.93011

Sydney N. Jackson, Rongson Pongdee
International Journal of Organic Chemistry, Volume 9, pp 96-105; doi:10.4236/ijoc.2019.92009

Abstract:The construction of the C(1) - C(5) fragment of the resorcylic acid lactone pochonin J is described. The synthesis is marked by the installation of the cis-1,3-diol moiety in a highly stereoselective manner using Evans’ intra-molecular base-catalyzed oxyconjugate addition of a hemiacetal-derived nucleophile. The synthetic route presented affords an efficient pathway to the preparation of this critical architectural feature that should facilitate the development of this secondary metabolite as a potential drug candidate.
Reda M. Abdel Rahman, Abdulrahman S. Alharbi, Nawaa A. Alshammari, M. Abdel Rahman Reda, S. Alharbi Abdulrahman, A. Alshammari Nawaa
International Journal of Organic Chemistry, Volume 9, pp 85-95; doi:10.4236/ijoc.2019.92008

Abstract:Novel 4-thiazolidione and 1,4-bis-thiazolidinone derivatives bearing antipyrine moiety have been obtained from condensation of 4-aminoantipyrine 1 with aromatic/heteroaldehydes followed by cycloaddition with mercaptoacetic acid in nonpolar solvents. Structure of the products has been deduced upon their elemental analysis and spectral measurements. Most of the targets evaluated as enzymatic effect towards some bacteria (E. coli) in compare with Xanthine oxidase (from buttermilk) where the role of compounds is an inhibition of purine metabolism enzymes caused by E. coli.
Laila M. Break, Mosselhi A. M. Mohamed, Ohoud A. A. Al-Thubaiti, Fatma E. M. Eibaih
International Journal of Organic Chemistry, Volume 9, pp 107-120; doi:10.4236/ijoc.2019.93010

Abstract:Pyrimidines, such as 6-amino-2-thio and 2-methylthiouracils and fused pyrimidines, such as thienopyrimidines reacted with 1-O-acetyl-2,3,5-tri-O- benzoyl-β-D-ribofuranose to get new derivatives of the corresponding nucleosides. The obtained protected nucleosides were deprotected by methanolic sodium methoxide to get the corresponding free uracil and thienopyrimidine nucleosides. The new nucleosides formed were tested for biological activity against some of microorganism (some fungi and bacteria species). Some of the tested products showed moderate activity and the results were reported.
Jonathan Román Valdéz-Camacho, José Domingo Rivera-Ramírez, Jaime Escalante
International Journal of Organic Chemistry, Volume 9, pp 10-22; doi:10.4236/ijoc.2019.91002

Alexander G. Bordon, Andrea N. Pila, Mariela I. Profeta, María J. Jorge, Lilian C. Jorge, Jorge M. Romero, Nelly L. Jorge
International Journal of Organic Chemistry, Volume 9, pp 1-9; doi:10.4236/ijoc.2019.91001

Abdullah Taha, Mahmood Amani
International Journal of Organic Chemistry, Volume 9, pp 23-36; doi:10.4236/ijoc.2019.91003