International Journal of Organic Chemistry

Journal Information
ISSN / EISSN : 21614687 / 21614695
Current Publisher: Scientific Research Publishing, Inc. (10.4236)
Total articles ≅ 315
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Latest articles in this journal

Asmaa L. Alanzy, Dina A. Bakhotm, Reda M. Abdel-Rahman
International Journal of Organic Chemistry, Volume 10, pp 39-62; doi:10.4236/ijoc.2020.102003

Angelbert F. Awantu, Yannick Stephane Fongang Fotsing, Godfred A. Ayimele, Edouard A. Nantia, Patrick V. T. Fokou, Fabrice F. Boyom, Celine K. Ngwang, Bruno N. Lenta, Silvère A. Ngouela
International Journal of Organic Chemistry, Volume 10, pp 1-16; doi:10.4236/ijoc.2020.101001

Abstract:
Two novel Schiff bases, 3-[1-(2-(phthalazin-1-yl)hydrazono)ethyl)-1,3-oxa- zinane (PHEO) and 2-[(2-(phthalazin-1-yl)hydrazono)methyl]phenol (PHMP), derived from hydralazine hydrochloride, an effective drug against hypertension, were synthesized and characterized by spectroscopic methods, Infrared (IR), Proton Nuclear Magnetic Resonance (1H NMR) and Carbon-13 Nuclear Magnetic Resonance (13C NMR). PHEO showed low antimicrobial activity against one bacterial strain with MIC value of 250 μg/ml while PHMP showed interesting activity against 4 bacterial strains with MIC of 31.25 - 250 μg/ml compared to the standard drug, amoxicillin. PHEO and PHMP showed higher reducing activity on ferric ions compared to Vitamin C. On lipid peroxidation, PHEO showed higher inhibition while PHMP showed lower inhibition compared to Vitamin C. Both compounds presented lower stimulating effect and lower catalase activity compared to the standard Vitamin C. PHEO and PHMP showed less than 80% inhibition in the preliminary antiplasmodial assay and so were not considered for the dose-response studies.
Abeer N. Al-Romaizan
International Journal of Organic Chemistry, Volume 10, pp 77-87; doi:10.4236/ijoc.2020.102005

Abstract:
In a search for new antimicrobial agents, some new spiro[indol-thiazolidon- 2,4-diones] (6a-c) were synthesized by condensation of 5-substituted isatins 1 with sulfanilamide in MeOH, followed by aroylation with p-nitrobenzoyl chloride in DMF to get compounds 4a-c. Cycloaddition of 4a-c with thioglycolic acid in a dry non-polar solvent (dioxane) gave the targets 6a-c. Also, bis(5-fluorospiro[indoline-3,2’-thiazolidine]-2,4’-dione) (9) was synthesized by condensation of 5-fluoroindoline-2,3-dione with benzene-1,4-diamine (2:1 by mol) in MeOH, which followed by cycloaddition with thioglycolic acid in dioxane gave compound 8. Acylation of the later with 2,2,2-trifluoroacetic anhydride in THF has yielded the target 9. Structures of the products have been deduced from their elemental analysis and spectral data. The in vitro antimicrobial activity of the new systems 6a-c, and 9 was tested.
Wafa Bawazir
International Journal of Organic Chemistry, Volume 10, pp 63-76; doi:10.4236/ijoc.2020.102004

Abstract:
In this review a five-membered heterocyclic ring having two adjacent nitrogen atoms known as Pyrazole, we have framed 5-amino-N-substituted pyrazoles in particular focusing on its substantial role as a building block and starting materials for producing enormous heterocyclic skeletons. The existence of this moiety in larger compounds renders them to expose medicinal, pharmacological and biological therapeutic activities. Enormous drugs contain 5-amino-N-substituted pyrazoles such as celecoxib anti-inflammatory, antipsychotic, anti-obesity, analgesic, and antidepressant. We reported various routes of synthesis and the use of these compounds.
Ali Bouattour, Mehdi Fakhfakh, Souhir Abid, Ludovic Paquin, Rémy Le Guével, Thierry Charlier, Sandrine Ruchaud, Stéphane Bach, Jean-Pierre Bazureau, Houcine Ammar
International Journal of Organic Chemistry, Volume 10, pp 88-103; doi:10.4236/ijoc.2020.102006

Eman F. Kirolos, Amal S. Yanni
International Journal of Organic Chemistry, Volume 10, pp 104-110; doi:10.4236/ijoc.2020.102007

Abdullah Taha, Mahmood Amani
International Journal of Organic Chemistry, Volume 9, pp 23-36; doi:10.4236/ijoc.2019.91003

Abstract:
In the oil and gas industry, water is essential element since it exists in most of the stages, starting from drilling operations, then production processes including injecting in the reservoir to maintain the pressure, and finally disposing the produced water from the reservoir. Therefore, it is very important to understand the water in the petroleum industry with its different types and study its effects on the reservoirs as well as the downhole and surface equipment. Most of the studies and literature reviews focused on the oil and gas properties. In fact, understanding the properties of the water is as important as the oil and gas properties. Water is always present in the oil and gas fields during production, injection or disposal. Therefore, it has a direct impact on the productivity and overall efficiency of the field and the entire development project. This paper is going to illustrate and focus on several objectives. First, it elaborates the importance of the water in the oil and gas fields. Then, it includes a comprehensive overview of different types of water in the petroleum industry including a summary about of their properties. The main two types that the paper focuses on are the produced water and the injected water. It clarifies the effects of both of them on the reservoir, well completions and facilities. After that, the paper touches bases on the common problems and issues caused by water along with a brief summary of steps needed by the operators to follow in order to solve them. In addition to that, the common monitoring procedures and tests that are usually followed to observe the quality of the water are going to be presented. Finally, couples of solutions used by operators are reviewed to solve the problem of excessive water production after the water breakthrough in the field.
Laila M. Break, Mosselhi A. M. Mohamed, Ohoud A. A. Al-Thubaiti, Fatma E. M. Eibaih
International Journal of Organic Chemistry, Volume 9, pp 107-120; doi:10.4236/ijoc.2019.93010

Abstract:
Pyrimidines, such as 6-amino-2-thio and 2-methylthiouracils and fused pyrimidines, such as thienopyrimidines reacted with 1-O-acetyl-2,3,5-tri-O- benzoyl-β-D-ribofuranose to get new derivatives of the corresponding nucleosides. The obtained protected nucleosides were deprotected by methanolic sodium methoxide to get the corresponding free uracil and thienopyrimidine nucleosides. The new nucleosides formed were tested for biological activity against some of microorganism (some fungi and bacteria species). Some of the tested products showed moderate activity and the results were reported.
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