Cellular & Molecular Immunology

Journal Information
ISSN / EISSN : 1672-7681 / 2042-0226
Current Publisher: Springer Science and Business Media LLC (10.1038)
Former Publisher:
Total articles ≅ 1,531
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Latest articles in this journal

Huiqing Xiu, Jiali Gong, Tiancha Huang, Yanmei Peng, Songjie Bai, Guirun Xiong, Shufang Zhang, Huaqiong Huang, , Gensheng Zhang
Cellular & Molecular Immunology; doi:10.1038/s41423-021-00698-5

Peter Lehmkuhl, Magdalena Gentz, Andres Caballero Garcia de Otezya, Bodo Grimbacher, Hendrik Schulze-Koops,
Cellular & Molecular Immunology; doi:10.1038/s41423-021-00701-z

Abstract:
Immune dysregulation diseases are characterized by heterogeneous clinical manifestations and may have severe disease courses. The identification of the genetic causes of these diseases therefore has critical clinical implications. We performed whole-exome sequencing of patients with immune dysregulation disorders and identified two patients with previously undescribed mutations in LRRC32, which encodes glycoprotein A repetitions predominant (GARP). These patients were characterized by markedly reduced numbers and frequencies of regulatory T cells (Tregs). Tregs with mutated LRRC32 exhibited strongly diminished cell-surface GARP expression and reduced suppressor function. In a model of conditional Garp deficiency in mice, we confirmed increased susceptibility to inflammatory diseases once GARP expression on Tregs was decreased. Garp deficiency led to an unstable Treg phenotype due to diminished Foxp3 protein acetylation and stability. Our study reinforces the understanding of the immunological mechanisms of immune dysregulation and expands the knowledge on the immunological function of GARP as an important regulator of Treg stability.
Elizabeth Fraley, Cas LeMaster, Dithi Banerjee, Santosh Khanal, ,
Cellular & Molecular Immunology; doi:10.1038/s41423-021-00700-0

Chaojia Chen, Jiali Peng, Shuaiya Ma, Yuming Ding, Tao Huang, Shigang Zhao, Lifen Gao, Xiaohong Liang, ,
Cellular & Molecular Immunology pp 1-3; doi:10.1038/s41423-021-00699-4

Ke Wang, Weijia Zhao, Rong Jin,
Cellular & Molecular Immunology pp 1-2; doi:10.1038/s41423-021-00697-6

Marie Robert,
Published: 21 May 2021
Cellular & Molecular Immunology pp 1-8; doi:10.1038/s41423-021-00694-9

The publisher has not yet granted permission to display this abstract.
, Marion Ferren, Olivia Harder, Francesca T. Bovier, Tara C. Marcink, Camilla Predella, , Jennifer Drew-Bear, N. Valerio Dorrello, Alex L. Greninger, et al.
Cellular & Molecular Immunology pp 1-3; doi:10.1038/s41423-021-00691-y

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