Journal of Pharmaceutical Quality Assurance and Quality Control

Journal Information
Total articles ≅ 5

Articles in this journal

Vinoothna Thelkar Venkata Durga, Parineethi Karanam, Jyoshna Pisini Vyshnavy, Sadasiva Rao Galaba, Srikanth Boga
Introduction: Breast cancer is the most prevalent cancer among women population. Pain during and after chemotherapy is of various types and has no background information on the mechanism and treatment. Aim: To analyse pain after chemotherapy in breast cancer patients. Materials and Methods: It was a Prospective Observational Cohort of 6 month time period at Omega Hospitals, Guntur with 76 patients. Data was collected by direct interaction either with the patient or the patient representative or by studying patient’s profile through questionnaire. Statistical Analysis: All the collected data was entered into Excel sheet (Microsoft Excel 2016 MSO (16.0.13328.20262) 32-bit: Windows 11 version). The collected data was transported to SPSS (version – 28) for analysis. Results: The intermittent pain was seen in most of the patients (40.8%) along with Continuous Pain (14.5%) & Predominantly Neuropathic Pain (3.9%). Conclusion: Inspite of robustic research on the characteristics of pain, patients complain of pain in other locations too. Also, researches should throw light on management, prevention and identification of pain by various techniques like radiation or surgery. We can certainly hope that by considering diagnosis, management, prevention we can improve clinical patient outcome with less adverse drug reactions.
Pillalamarri Sravan Kumar, Surabhi Goyal, Amit Kumar
Objective: The objective of this work is to prove and validate Tangential Flow Filtration System for high yield drug substance of vaccine as product and also to provide the experimental insight for vaccine industrial personnel to acquire the knowledge on the process validation of the system to obtain high and consistent yield of the product. Methods: The method in this work involves the experimental determination of the process parameters for Tangential Flow Filtration system such as Trans-membrane pressure and flux including validation of these parameters to achieve the high yield drug substance with consistency. The experiment entails the execution of three validation batches with different variables during the process and standardized at the point of maximum yield with similar reliability. Results: The performed validation of Tangential Flow Filtration system was so optimal and suitable for identification of parameters that controlled the yield of the drug substance consistently and validated accordingly. Statistical evaluation of the optimized parameters results from three consecutive batches was done and the mean was calculated individually as 0.25 bar for TMP, 0.4 LMH for flux and 402.6mg/mL for drug substance yield. Conclusion: The considered approach in the process validation of Tangential Flow Filtration system includes independent verification and application of parameters, which supports maximum yield of the vaccine product. The execution of these batches was successfully carried out in the laboratory that involves the purification of the upstream harvest sample for obtaining the maximum and consistent yield concentration of the drug substance with the decisive designing and validation of process parameters.
Amit Gosar, Tabrez Shaikh, Atharva Sindwani
Synthesis of chiral drugs required chiral starting materials organic compounds. DL serine is an amino acid that is used as a key starting material in the synthesis of many drug substances. D or L isomer of Serine will lead to the chiral drug substances whereas DL mixture will lead to racemic drug substances. FTIR can be used as the primary analytical tool for the identification of Serine isomers and its racemic mixture. Many absorption bands in FTIR spectra identify whether a molecule is a specific isomer or racemic mixture. A systematic comparison of FTIR spectroscopic data is carried out revealing that the compound is the specific isomer and the racemic mixture shows different spectra with different bands.
Avisek Dutta
Jaggery has been used traditionally in all Indian villages. It is a concentrated product of cane juice which has 50% sucrose, up to 20% invert sugars, and also contains insoluble matter, such as wood ash, proteins, and fibres, whereas granulated sugar, refers to sucrose, a disaccharide composed of glucose and fructose. Jaggery is better option than sugar in diabetics since it reduces oxidative stress in diabetic patients. Sugar intake on long term causes dysglycemia. Constant raised sugar levels have produces central adiposity, hypertension or some elevation of blood pressure, hyperglycaemic episodes in form of glucose intolerance. Artificial sweeteners on long term usage can be possibly not favourable as they cause weight gain, hypertension. There is no corelation of any tumour production with Aspartame.
Back to Top Top