EXPERIMENTAL & CLINICAL MEDICINE GEORGIA

Journal Information
ISSN / EISSN : 1512-0392 / 2667-9736
Published by: Association For Science (10.52340)
Total articles ≅ 173
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Anzor Gogiberidze, Ramaz Khetsuriani, Ramaz Chikhladze, Marina Phailodze, Manana Arabuli-Chlikadze, Elene Shvangiradze
Published: 6 September 2022
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA; https://doi.org/10.52340/jecm.2022.06.023

Abstract:
The volume of the extracellular matrix rises along with the age increase. The presence of intercellular junctions and the exchange processes of electrical impulses and ion currents carried out via them is a critical component in the functioning of cardiomyocytes (both primary and secondary). The intercalated discs may engage in compensatory-adaptive responses resulting from age-related involutional processes, as evidenced by an increase in their quantity in the hearts of older rats. The structural integrity of the intercalated discs in young and middle-aged rats may be directly correlated with the highly functional capabilities of the heart muscle. It would be interesting to conduct a more in-depth study of the intercalated discs using immunohistochemical techniques and a comparative analysis of disc histological structure in rats of various ages by extrapolating the findings on the functional capabilities of cardiomyocytes.
Natia Chkheidze, Niko Uridia, Elene Giorgadze, Marina Nikolaishvili, Ana Malazonia, Tamar Zerekidze
Published: 6 September 2022
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA; https://doi.org/10.52340/jecm.2022.06.012

Abstract:
Purpose: The aim of the research was to identify the plasma ghrelin concentration in humans with Type 2 Diabetes mellitus and obesity and to investigate a statistically significant relation between plasma ghrelin levels and other important metabolic factors in Type 2 Diabetes mellitus and obesity pathogenesis.
Nino Sanodze, Nano Shvangiradze, Tinatin Ovsephian
Published: 6 September 2022
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA; https://doi.org/10.52340/jecm.2022.06.008

Abstract:
Patients with acute vomiting, typically for hours to a few days, most often present to an emergency department, whereas patients with chronic symptoms are more often initially evaluated in outpatient office settings. Emergency department clinicians should expeditiously exclude life-threatening disorders such as bowel obstruction, diabetic ketoacidosis, adrenal crisis, toxic ingestion, or increased intracranial pressure (ICP). In both urgent care and routine outpatient settings, the following three steps should generally be undertaken in patients with nausea and vomiting:
Tamar Sharashenidze, Maia Enukidze, Marine Machavariani, Nino Otarishvili, Tea Gabunia, Tamar Sanikidze
Published: 6 September 2022
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA; https://doi.org/10.52340/jecm.2022.06.002

Abstract:
Our research aimed to establish the effectiveness of various β-adrenergic receptor blockers in the regulation of T cell proliferation in the model system of the Jurkat cells.Material and Methods. The research was conducted on the human leukemic mature T cells (Jurkat cells) (DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen (Germany)) activated by phytohemagglutinin (PHA). Viability and proliferative activity of intact and PHA-stimulated Jurkat cells under the influence of Nebilet, Egilok, Betalok Zok, and Propranolol were studied with the MTT test. Results. Study results show that β-adrenergic receptors blockers selectively influence the activity of mitochondrial dehydrogenases, and therefore viability in both intact and mitogen-stimulated Jurkat cells. In particular, Nebilet, Betalok Zok, and Propranolol induced a statistically significant decrease of intact Jurkat cells viability by 63%, 20%, and 32%, respectively; Egilok and Betalok Zok (25mg) didn’t statistically significantly affect the PHA- activated Jurkat cells viability. Nebilet, Betalok Zok (50 mg), and Propranolol decreased the viability of the mitogen (PHA) activated Jurkat cells (for PHA dose 20μg/ml) and didn’t affect at a PHA dose of 50μg/ml.
Tinatin Kacharava, Elene Giorgadze, Shota Janjgava, Nino Lomtadze
Published: 6 September 2022
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA; https://doi.org/10.52340/jecm.2022.06.009

Abstract:
Vitamin B12 is distinguished by its unique beneficial properties that play a major role in the proper functioning of the body. Interest in vitamin B12 began 2 centuries ago and it is still relevant to study its role. Vitamin B12 plays a special role in the proper functioning of the immune system. With increasing statistics in the autoimmune disease registry around the world (including the most common thyroid autoimmune disease), the interest in medicine is to determine the correlation between vitamin B12 and autoimmune diseases. Various studies have shown a correlation between them, although there is a little evidence for a link between vitamin B12 and autoimmune diseases of the thyroid gland.
Irina Andronikashvili, Gaiane Simonia, Diana Labartkava, Nato Pantsulaia
Published: 6 September 2022
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA; https://doi.org/10.52340/jecm.2022.06.007

Abstract:
It has been known that metabolic syndrome (MS) is a powerful predictor of cardiovascular disease. Data on gender related differences in MS is relatively scarce. The underlying mechanism of increased salt-sensitivity among individuals with the metabolic syndrome is not fully understood. There are some studies that prove that female sex is a major risk factor for salt-sensitive hypertension. The study aimed to assess an association between salt-sensitive hypertension and MS, to investigate potential role of gender in these disorders. Results of our study showed that in Georgia hypertensive subjects consume high amount of sodium. Prevalence of salt-sensitivity in Georgian middle-aged individuals exceeds average values and is more common in females. As a main finding, this study showed high prevalence of MS and a positive significant association of this syndrome with female gender and salt-sensitive hypertension. Early detection and knowledge of gender differences in MS and salt-sensitivity can help design gender specific preventative and therapeutic strategies that will have a positive impact on overall population health.
Maia Matoshvili, Nino Adamia, Ia Pantsulaia, Dimitri Abelashvili, David Topuria, Daredjan Khachapuridze
Published: 6 September 2022
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA; https://doi.org/10.52340/jecm.2022.06.011

Abstract:
The aim of our study was an investigation of epidemiological peculiarities of allergic dermatitis in children and adolescents (distribution of atopic dermatitis, contact dermatitis, seborrheic dermatitis, urticaria and angioedema, psoriasis) in the population of Georgia.
Irine Korinteli, Mzia Khalvashi, Eliso Turkadze
Published: 6 September 2022
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA; https://doi.org/10.52340/jecm.2022.06.026

Abstract:
In recent years, the pandemic situation had an impact on scientific works, and the main focus had been shifted to the modern problem – COVID-19. Many medical issues have fallen into the shadows, such as evidence-based medicine. The aim of this work is to review articles about evidence-based medicine. Evidence-based Medicine is the integration of best research evidence, clinical expertise, patient values. The concept of evidence-based medicine includes five main steps: Formulation of answerable clinical questions, Searching for evidence, Critical appraisal, Applicability of evidence, Evaluation of performance.Today the evidence-based medicine is the main rule to use the best decision for medical services for individual patients.
Irakli Chkhikvishvili, David Chkhikvishvili, Nunu Gogia, Maya Enukidze, Marine Machavariani, Nana Kipiani, Eka Shekhiladze, Tamar Sanikidze
Published: 6 September 2022
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA; https://doi.org/10.52340/jecm.2022.06.015

Abstract:
Cancer plays a leading role in increased morbidity and mortality in the world. In recent years, special attention has been paid to the use of natural medicines among the new effective methods of cancer treatment. Paclitaxel can be isolated from the hazelnut’s (Corylus avellana L.) shells and leaves. Taxane-polyphenols synergism is known to enhance the efficacy and selectivity of chemotherapeutic drugs. Therefore, screening of taxane-polyphenol combinations is needed to select a highly effective complex. The aim of the study was to study the effectiveness of different polyphenol substitute fractions obtained from hazelnut residue extraction on tumor cell viability in Jurkat cell model systems. Studies were performed on human leukemia transformed mature T-cells (Jurkat cells) (DSMZ-Deutshe Sammulung von Mikroorganismen und Zell kulturen (Germany)). Extraction of compounds from the nut residue (hard shell) was carried out using solvents, chloroform, ethyl acetate, methanol and ethanol (Sigma-Aldrich). Chromatographic separation was performed on a high-pressure liquid chromatograph Agilent 1260 Infinity (USA).Based on the analysis of the research results, we can conclude that the ethanol extract of hazelnut shells which is characterized by a small content of paclitaxel, but a high content of polyphenols, is characterized by most high cytotoxicity against Jurkat cells.
Nikoloz Vachadze, Ramaz Khetsuriani, Marina Pailodze, Manana Arabuli-Tchlikadze
Published: 6 September 2022
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA; https://doi.org/10.52340/jecm.2022.06.020

Abstract:
The aim of the study was to evaluate the volume of the left atrium by ultrasonography after dosed, moderate-intense treadmill exercise for 10 weeks in healthy rats aged 10-11 weeks. In general, physical exercise is a well-known preventive method for reducing the risk-factors of cardiovascular diseases. Within the frame of our study, we subjected 10-11-week-old healthy male rats to moderate-intensity physical exercise on treadmill for 10 weeks and then studied functional parameters of heart by echocardiography to assess the effect of physical exercise on the volume of left atrium of healthy heart. Rats were divided into 2 groups: 1) control group, which did not receive any exercise (n=6); 2) the investigational group performed 6 complete rotations on treadmill per day with a 2-minute active break in between, 5 days a week (treadmill speed 12m/min, incline 200) – n=6.The functional parameters of heart were evaluated by transthoracic echocardiography twice (at the beginning of the study and after 10 weeks). In the rats of the investigational group, the volume of the left atrium was increased compared to the data of untrained rats of the same sex and age. The mentioned study can be considered as another step forward in the study of compensative changes developed amid physical exercise with moderate intensity.
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