Abundant herbal remedies separately or in combination have been recommended in various medical treatises for the remedy of different diseases, Trianthema decandra Linn, (Family: Aizoaceae) familiarly known as Vellai Saaranai (Tamil) and Punarnavi (Sanskrit) is a procumbent herb widespread in the tropical and subtropical regions of the world, and also found abundantly in India. It has been widely known in different system of traditional medicines, used efficiently in Siddha for the treatment of diseases and ailments of human beings. The current study aims to endow up-to date standardized data of Saaranai ver chooranam (SVC) indicated for Gunmam with distinct observations such as physicochemical, phytochemical, biochemical, HPTLC, analysis of heavy metal, microbial load, specific pathogen, pesticide residue, aflatoxin parameters were evaluated as per PLIM guidelines, gathered and orchestrated in a prompt manner on this paper, to explore and inspire further ethno-botanical and ethno-pharmacological research and investigations towards drug discovery.

Aavarai Poovarisi Chooranam is a Siddha poly herbal formulation plays an important role in treating Diabetes alone or in combination. Chooranam is applied to the powder made by a single or a mixture of herbal ingredients. The drugs required for making Aavarai Poovarisi Chooranam were collected and authenticated by experts and prepared as per siddha literature. It was then subjected to preliminary phyto-chemical analysis, physico-chemical, high performance thin layer chromatographic finger printing was done through CAMAG software, biochemical analysis, heavy metal analysis, pesticide residue, aflatoxin and microbial load analysis prior to toxicology and pharmacology testing. The obtained results were within normal limits in this study, which is briefly described in this paper.

Background: The present study is anticipated the perspective of physico chemical characteristics of the traditional Siddha medicine Kodi pavala chunnam . It is a herbo mineral formulation which treats the Cholelithiasis & it's related symptoms. Materials and Methods: The drug was prepared as mentioned in the Siddha literature Noigaluku Siddha parigaaram part 2 .Then the prepared drug was undergone physicochemical, biochemical, organoleptic and phytochemical analysis and HPTLC. Results: Loss on drying at 105°C was 0.8667 ± 0.4041,Total ash (%) was 55.67 ± 9.603,Acid insoluble ash (%) 0.64 ± 0.02,Water soluble extractive was 3.1 ± 1.044, Alcohol soluble extractive (%) was 0.2533 ± 0.0611, the PH was 8 which indicates alkaline nature of the drug. From the results the drug was free from microbial contamination . Heavy metals and Pesticide residues were below the quantification limit.Conclusion: The result shows that the drug is of standard quality and can be used as reference in laying pharmacopoeia standards. From the results obtained in the above investigations it was concluded that the drug is effective biologically active components which may helps in treating cholelithiasis and it's related ailments.

Most of the formulations in the Siddha system is very effective but they have not been standardized. Any drug should be standardized before clinical use. There are various formulations in Siddha to treat cardiovascular diseases. One among them is the poly-herbal formulation MaaradiappukuChooranam, but it has not been validated so far. The principal intention of this current study is to regularize the drug ‘Maaradaippuku chooranam’ by physicochemical, phytochemical and biochemical evaluation through modern Analytical techniques. The organoleptic characteristics of the Chooranam are in solid form which is pale brownish in colour and soft to touch with a characteristic odour which reveals the quality of the formulation. The aflatoxin assay showed the chooranam is free of aflatoxins. The outcomes of the study for pesticide residue show no traces of pesticide residue in the chooranam. This polyherbal formulation does not contain microbial contamination and displays the existence of steroids, alkaloids, triterpenoids, phenols, tannin, saponin and sugar. The ash value is 9.5 ± 0.4%. Heavy metals like Arsenic, Lead, Mercury and Cadmium are below the detectable limit.

Natural dosage forms, from vegetation, have been the groundwork for curing human diseases. The history of disease remedies is rooted in the existence of human civilization. The existing day medication system has advanced over the years with the aid of the enduring scientific and observational efforts of researchers; however, the groundwork for its improvement remains rooted in usual medicine. Plant-based drugs which have been used as crudes now serve as the groundwork for advanced drug discovery. The indigenous information of herbal fabrications has been surpassed down from technology to era which has extensively contributed to the development of special typical structures of medicine. This review gives a short account of protein-rich grains which are obtained from plants fabricated with current friendly formulations.

Background: The current study is pointed at the characterization of the physico-chemical analysis of the traditional Indian Siddha medicine, Naaga Chendooram (NAC). It is a metal based medicine which cures specially for breast cancer. Literature survey revealed that scientific study was lacking for this drug. Materials and Methods: Naaga chendhooram was made as per Veeramamunivar siddhar method. The ingredients were Zinc, Potassium nitrate, Zingiber officinale, Curcuma longa and Carum copticum and Aspera bidentata. The prepared drug was analysedin Fourier Transform Infra-Red (FTIR) for its chemical properties which helps in identification and localisation of chemical species, scanning electron microscopy (SEM). FT-IR spectroscopy has been used to study the presence of organic substances, physiochemical, organoleptic and biochemical were analysed. Results: Loss on Drying at 105 °C 1.053 ± 0.1747%,Total Ash 91.6 ± 3.7360%, Acid insoluble Ash 0±0%, Water soluble Extractive 6.367 ± 2.779%, Alcohol Soluble Extractive 1.46± 0.73%.,pH 7.5.It has the acid radical-carbonate and sulfates and basic radical- mercury and in the instrumental analysis it has arsenic group. Conclusion: Findings divulges that samples were need more studies to standardize the drug and to determine the importance of Siddha drug preparation technique, which may discloses the scope for chemical modulation by traditional methods in succeeding years.

Pharmacogenetics involves the association of properties in a singular response to drugs. All in all, the field covers a vast region, including essential drug discovery research, the hereditary premise of pharmacokinetics and pharmacodynamics, new drug improvement, hereditary patient testing, and clinical patient management. Ultimately, the goal of pharmacogenetics is to predict a patient's inherited response to a particular drug in order to mediate the most ideal clinical treatment. By anticipating an individual's drug response, it will be possible to amplify the results of treatments and reduce the incidence of unfriendly side effects.

Cancer is one of the main problems in the India and world also. From the world health organization report (2022), 10 million deaths in the year of 2022 of the entire world. This reflects one in six deaths. Side effects are very common in the cancer treatment process i.e. chemotherapy, radiotherapy and chemo radiation therapy. Proper knowledge is required in these aspects. Sometimes these side effects lead to life threatening due to lack of knowledge on side effects management while patients are in the home. These patients also need counseling, consultation and about side effects management of their treatment. This counselling leads to not only the patient’s quality of life but also improve the patients’ psychological conditions during their treatment process. In our prospective observational study, the main objectives are checking the effectiveness of before counselling and after counselling with respect to patient’s side effect management and psychological effectiveness. Finally evaluate the outcome with the counselling in both breast and cervical cancer patients. We provide counseling for cancer patients in King George Hospital, Visakhapatnam, India. In our study we used EORTC QLQ – C30 (version 3) scale for comparison of with or without counseling in the areas of side effect management, effectiveness of psychological and nutritional in breast and cervical cancer patients. Finally in our study we noticed that mostly rural area and some urban people were lack of knowledge on side effect management of cancer treatment. By providing better counseling to these patients especially in rural area people for their treatment and create awareness of cancer in group counseling for care givers then automatically better side effect management was possible in cancer patients. Pharmacist counseling is one of the important services that has been associated with improved outcome.

3D Printing is an expeditious space of investigation in the pharmaceutical field, due to its flexibility and feasibility. This is an additive process of stacking materials in layers to form a solid object by means of a 3D Printer. Fabrication of the product has been done with the instruction based on a CAD file. The 3DP technologies developed includes Selective Laser Sintering, Stereolithography, Fused Deposition Modelling, Thermal Inkjet printing, Zip dose technology etc. and this article will discuss each technique in detail. Aprecia’s Spritam is the first FDA approved 3D printed medicine, developed by means of Zip dose technology. The ultimate advantage by the adaptation of this technology is due to its potential ability for dose tailoring and personalization. Though the technology is much accessible, this is overdone with numerous regulations.

AIM: To study drug-drug interactions in myocardial infarction patients. METHODOLOGY: A prospective interventional study was done on myocardial infarction with drug interactions patients admitted in tertiary government and corporate hospital, Visakhapatnam Andhra Pradesh, India. Information regarding the gender, risk factors, type of drug interactions as major, moderate, minor were recorded in a standard questionnaire (case report form).RESULTS: A total of 100 cases were included after excluding missing data. Out of 100 cases,62 were male and 38 were female.Myocardial infarction in patients in which we assessed risk factors among them were HTN-67%,previous history of CVD-66%,family history-60%,Hyperlipidemia-40%,Diabetes milletus-38%,smoking-64%,Drug interactions were Major,Moderate,Minor.Major interactions were 24, Moderate interactions were 318, Minor interactions were 91.CONCLUSION: Based on the above data risk factors mostly seen in HTN and previous history of CVD, drug interactions mostly observed were moderate drug interactions.