TSMU COLLECTION OF SCIENTIFIC WORKS

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ISSN / EISSN : 1987-8990 / 1987-8990
Published by: Association For Science (10.52340)
Total articles ≅ 31
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David Gotsiridze, Ketevan Baramidze, Tamar Chikhladze, Tamar Otarashvili, Hilda Ioramashvili
TSMU COLLECTION OF SCIENTIFIC WORKS, Volume 55, pp 60-63; https://doi.org/10.52340/csw.2022.05.927

Abstract:
A sensitive, accurate and efficient liquid chromatographic method has been developed for determination of nitrofuran residues in a honey sample; It was found that the detection minimum for all four nitrofuran group substances is 0.03 μg / ml, the specific wavelength is 376 nm, the specificity coefficient of variation for both on one working day and one working week is <2%, accuracy for solutions of three different concentrations is <2 %, The accuracy of the method for all four test substances is 0.999 (> 0.99); Sample preparation is satisfactory as the obtained sampling coefficient is> 0.6. Thus, as a result of validation of the liquid chromatographic method developed for the quantitative determination of nitrofuran residues in the honey sample, the method was fully complied with the requirements of the Government of Georgia according to the following validation characteristics: detection minimum, specificity, accuracy, correctness and linearity. (#499, Guidance for Industry Bioanalytical Method Validation U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) Center for Veterinary Medicine (CVM) May 2001).
Teona Kekeishvili, Maia Merlani, Lela Amiranashvili, Lali Gogilashvili, Vakhtang Barbakadze
TSMU COLLECTION OF SCIENTIFIC WORKS, Volume 55; https://doi.org/10.52340/csw.2022.05.930

Abstract:
A high-molecular water-soluble preparation from stems of Borago officinalis (Boraginaceae family) was isolated. According to data from UV, IR, 1H, 13C NMR, gCOSY and 2D heteronuclear 1H/13C gHSQCED experiments, the main chemical constituent of this water-soluble high-molecular preparation from stems of Borago officinalis (HMP-BS) was found to be a biologically active caffeic acid-derived polymer, namely poly[oxy-1-carboxy-2-(3,4-dihydroxy­phenyl)­ethylene] also referred to as poly[3-(3,4-dihydroxyphenyl)glyceric acid] (PDPGA). PDPGA was previously detected in high-molecular preparations of Symphytum asperum, S. caucasicum, S. officinale, Anchusa italica and Cynoglossum officinale. The detection of this compound in different genera of the Boraginaceae family is interesting as this unusual caffeic acid-derived polymer could be consider a chemotaxonomic marker among Boraginaceae plants. Thus, PDPGA is interesting due to the importance of its chemotaxonomic significance, the potential biomedical applications of the Boraginaceae plants and the chemical importance of PDPGA. The presence of poly[3-(3,4-dihydroxy­phenyl)­glyceric acid] in multiple Boraginaceae species expands the resources of raw materials for this biologically active polymer.
Durmishkhan Turabelidze, Tsitsana Sulakvelidze, Bela Kikalishvili, Manana Malania
TSMU COLLECTION OF SCIENTIFIC WORKS, Volume 46; https://doi.org/10.52340/csw.2021.686

Abstract:
There is studied chemical composition of neutral and polar lipids of the seeds of: Medicago sativa, Amaranlhus cmentus and Amaranthus retroflexus growing in Georgia. The composition of free fatty acids was determined with help GLC and HPLC. There is determined class and fatty acidal composition of them, qualitative and quantitative determination of phospholipids is carried. There is elaborated various medicinal forms from Medicago sativat.
Tsitsi Parulava, David Pruidze, Maia Chkhaidze, Tamar Gotua, Irma Mandjavidze
TSMU COLLECTION OF SCIENTIFIC WORKS, Volume 42; https://doi.org/10.52340/csw.2021.623

Abstract:
Gluten sensitive enteropathy-celiac disease is an immune-mediated disorder caused by permanent sensitivity to gluten in genetically susceptible individuals. Epidemiologic studies of last years suggest that it is common and may occur in 0,5-1% of the general population. The bowel inflammatory and immunologic response results in atrophy and damage in the small bowel and secondary malabsorbtion. The mode of presentation can be quite variable. Celiac disease is generally defined as chronic diarrea and failure to thrive in infants and toddlers, diarrhea is still the most common symptom, but disease may occure in different age groups and with exstraintestinal, sometimes monosymptomic clinic. Clinical forms of celiac disease are: classic, atypical, silent, latent and potential. Definitive diagnose of Celiac disease requires serrologic screening, small intestinal biopsy and effectiveness of elimination diet. Anti-tissue transglutaminase antybody test (TTG IgA and TTG IgG) is highly sensitive, specific and less expensive, thus is recommended for general practice. None of serologic tests are 100% reliable. Definitive diagnosis requires characteristic histologic changes in intestine mucus. Tissue for investigation may be taken from duodenum during gastro endoscopy. Diagnosing only by results of gluten-free diet is not correct. The only treatment for celiac disease is lifelong exclusion of gluten. Early diagnosis and strict dietary restrictions appear to be the only possibility of prevention risk for failure to thrive, delay of sexual maturity, autoimmune disorders, adenocarcinoma of gastrointestinal tract and lymphoma.
Zurab Vadachkoria, Мarina Giorgobiani, Lia Dzidziguri
TSMU COLLECTION OF SCIENTIFIC WORKS, Volume 38, pp 154-157; https://doi.org/10.52340/csw.2021.565

Abstract:
87 children were investigated, with lip and palate clefts. Since the hypoxia background is observed in the investigated contingent. diazepam was used by us in pre and postoperative periods. The valuable proceeding of combined and nasotracheal narcosis, also a reducing of hypoxial phenomena in postoperative period were stipulated by using of diazepam, in order to estimate the obtained results, the control group was used, in which premedication and posoperative analgesia were carried out by traditional method.
Zurab Vadachkoria, George Kipiani, Omar Khardzeishvili
TSMU COLLECTION OF SCIENTIFIC WORKS, Volume 38, pp 452-454; https://doi.org/10.52340/csw.2021.566

Abstract:
Employing а series of monoclonal antibodies directed against B cell subsets using the streptavidin-biotin complex method. We have studied the distribution of immunocompetent cells in sections of tonzills from 64 patients with inflammatory disease and dental caries. The following conclusion can he made inregard to our study. The persentage of CD20+ B limfocytes decreases in all compartments of tonzils with increasing caries activity. The reason for this may depend on a change of limfokine profiles produced by the angaged antigen presenting cells and T-cell subsets.
Marika Gogotishvili, Nino Abashidze, Merab Iverieli, Xatia Gogishvili, Nino Gogebashvili
TSMU COLLECTION OF SCIENTIFIC WORKS, Volume 49; https://doi.org/10.52340/csw.2021.465

Abstract:
The aim of our research was to study efficiency of applying the new national gelLazolex (5%) during the treatment of chronic recurrent apthous stomatitis. To achieve this aim we examined and treated 14-60 years old 50 patients. The patients were devided into two groups. One group included 20 patients (40±0,77%) -control group and the second one -30 patients (60 ±0,63%)- the main group . We used the same treatment in both groups, but in the main group during the local treatment we applied the gel Lazolex (5%) and in the control group we used vitamin A, vitamin E and briar oil. Studies of our examination showed that in the control group the aphtes during phibrinal form started epithelization in 7-14 days - remission was 3-4 month. aphtes during necrotic forms started epithelization in 10-21 days - remission was 2-4 month. aphtes during glandular forms started epithelization in 14-20 days - remission was 1-2 month. After applying Lazolex epithelization started in 3-6 days during phibrinal form - remission was 6-9 month, in 7-14 days during necrotic form - remission was 4-6-7month, in 9-14 days during glandular forms - remission was 3-5 month. Thus, it is recommended to apply Lazolex during the treatment of chronic recurrent apthous stomatitis “Lazolex” is national, cheap, herbal gel that accelerates epithelization and growth the remission precess.. It does not have side effects.
Marika Gogotishvili, Nino Abashidze, Merab Iverieli, Xatia Gogishvili, Nino Gogebashvili
TSMU COLLECTION OF SCIENTIFIC WORKS, Volume 48; https://doi.org/10.52340/csw.2021.464

Abstract:
The aim of our research was to study efficiency of applying the new national gel Lazolex (5%) during the treatment of chronic recurrent apthous stomatitis. To achieve this aim we examined and treated 19-55 years old 54 patients. The patients were devided into two groups. Each group included 27-27 patients. We used the same treatment in both groups, but in the first group during the local treatment we applied the gel Lazolex and in the second group we used the ointment zovirax(5%). Studies of our examination showed that the 19 patients (70,37±0,42%) from the first group 27(50±50) had important improvement, 6 patients (22,22±1,87%) had improvement. there was no efficiency in 2 patients (7,41±1,87%) with grave forms of chronic recurrent apthous stomatitis. In the second group after applying Zovirax only five patients from 27 (50±0,5%) had important improvement with the easy forms of chronic recurrent apthous stomatitis (18,52±0,9%) improvement was shown with 15 patients (55,6±0,8%). 7 patients (26,16±1,67%) from which 2 had grave forms and 5 had medium forms of disease had no efficiency. It is concluded that applying of national gel Lazolex (5%) accelerates the epithelisation on lips and skin and growth the remission process of disease. It does not have side effects . Thus, it is recommended to apply Lazolex during the treatment of chronic recurrent apthous stomatitis.
Ana Shamanadze, Irma Tchokhonelidze, Tamar Kandashvili, David Gordeladze
TSMU COLLECTION OF SCIENTIFIC WORKS, Volume 53; https://doi.org/10.52340/csw.2021.459

Abstract:
Chronic kidney disease is a global problem. Increasing evidence suggests that interstinal microflore is altered in patients with Chronic Kidney Disease (CKD).The gut microbiome is a key driver of chronic inflammation. Many of uremic retention solutes are produced by dysbiotic intestinal microflore that may have a great impact on survival of the CKD patients. Our sample study consisted of 147 patients (78 female, 69 male age 18-75) undergoing hemodialysis in one dialysis center. Data were collected by the completion of a scpecially designed questionnaire. Patients received hemodialysis therapy for 4-5 hours sessions, three times weekly using polysulfone dialyzers. It was revealed significant alteration of the colonic bacterial flora in hemodialysis patients, with the excess of the uremic toxin producing bacteria. Also, there was strict correlation between gut dysbiosis and HD patent's QoL.
Natia Katamadze, Tamar Kandashvili, David Metreveli, David Gordeladze
TSMU COLLECTION OF SCIENTIFIC WORKS, Volume 54; https://doi.org/10.52340/csw.2021.435

Abstract:
Diabetes mellitus is one of the most common chronic disease. In a number of developing and industrialized countries, diabetes mellitus has become an epidemic and is one of the leading causes of death. The rapid increase of cases of type 2 diabetes mellitus (T2DM) in the past decades has made it a widespread metabolic disorder. In recent years, an increasing understanding of how our microflora is linked to obesity-related T2DM has provided a new potential target for reducing the risk of T2DM. The aim of our project is to expand our view on the key roles of microflora during the onset and development of T2DM as well as its complications. Our aim was to study 2 groups of people with T2DM and Prediabetes in order to reveal any gastro-intestinal problems. According to questionnaires, it appeared that patients with diabetes type 2 had 3 or more gastrointestinal disorders, 72 % had bloating, 16% constipation and 12% diarrhea. Patients with prediabetes had 3 and more intestinal disorders: 56 % had bloating, 23% constipation and 21 % diarrhea. Despite, multiple studies supporting the importance of gut microbiota in pathophysiology of T2DM, the field is in early stage. Currently, we have reached a point in our understanding that some probiotics and related molecular mechanisms may be involved in glucose metabolism related to T2DM. We should work towards precision/personalized medicine selecting anti-diabetics and probiotics for a given patient to treat patients successfully.
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