Journal of Chemistry and Nutritional Biochemistry

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EISSN : 2709-5932
Published by: SABA Publishing (10.48185)
Total articles ≅ 18
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Hani Yahya Alfaifi, Majed Marji Alenezy, Talal Telhi Alenezy, Faiz Nasser Alenazy, Ahmed Mohammed Aleneze
Journal of Chemistry and Nutritional Biochemistry, Volume 3, pp 11-23; https://doi.org/10.48185/jcnb.v3i1.545

Abstract:
The foremast threats to human health from heavy metals are related with use tobacco when inserted in the human body by smoking ( shisha and cigarette ) or chewable like shammah which is harm of health. The tobacco species have been collected from different places, natural or included in the installation of some of the species sold in the markets. The samples were analyzed by wet digestion method and standardized. International protocols were followed for the preparation of material and analysis of heavy metals contents and analyzed by Inductively coupled plasma spectrometer Model-Varian720 ES in center Laboratory in Meteorology, Environment and Arid Land Agriculture, and Center of Excellence in Environmental Studies, King Abdulaziz University (KAU). Results obtained using ICP-OES technique for determination of heavy metals in Tobacco products. Through this study the results were shown the heavy metals which found in tobacco samples is clearly. the objective of the study showing the concentrative the heavy metals in tobacco and compared with levels of heavy metals allowing in the World Health Organization (WHO ). What the results indicate is the seriousness of the presence of heavy metals, which cause serious diseases such as cancer and failure in most organs. The use of tobacco should be abandoned.
Journal of Chemistry and Nutritional Biochemistry, Volume 3, pp 1-10; https://doi.org/10.48185/jcnb.v3i1.512

Abstract:
Background and Objectives: The present study was designed to assess the antileprotic effectiveness of some bioactive natural compounds towards enoyl acyl carrier protein reductase inhibition. Leprosy still constitutes a global pandemic in spite of long years of discovery. The current therapy option is multi-drug treatment using a combination of Dapsone, Rifampicin and Clofazimine. However, mycobacterium leprae counteracted by mutating the drug targets which necessitates the search for novel targets. One such target is enoyl acyl carrier protein reductase that mediates the fatty acid biosynthesis. Materials and Methods: Multiple (14) ligands of natural origin were drawn from PubChem database and their ADMET parameters were preicted using ADMETLab 2.0 webserver. After, the ligands were docked against the enzyme (PDB ID: 2NTV) at its active site using iGEMDOCK software. Results: ADMET parameters of the tested ligands proven to be accepted by Lipinski's rule of five except for two ligands. Furthermore, molecular docking results revealed that all of the tested compounds showed better binding energy than the reference drug Dapsone. The best of which was silymarin. Conclusion: The tested natural ligands have the capability to control M.leprae.
Hassan Alzahrani, Nawaf Almuntashiri, Rahma Kofiya
Journal of Chemistry and Nutritional Biochemistry, Volume 3, pp 44-52; https://doi.org/10.48185/jcnb.v3i1.546

Abstract:
Stem cells are unique and highly powerful cells, which have immense potential for treating various conditions. There are different types of stem cells based on the sources they are derived from and also based on their ability to differentiate into other types of cells. The detailed study of stem cells is important for scientists to understand how the cells grow and differentiate, and how the human body works on a cellular level. In addition to the research interest in stem cells, the clinical applications of stem cells are increasing constantly. Stem cells can be induced to change into new cells of specific tissues or organs, which can then be used for treating diseases. There are already a few established stem cell therapies, and many more in clinical trials.
Adekunle Olaoye
Journal of Chemistry and Nutritional Biochemistry, Volume 3, pp 37-43; https://doi.org/10.48185/jcnb.v3i1.536

Abstract:
Three (3) varieties of Cola, a tropical African crop of the family Sterculiacea, were gotten from Ikirun, State of Osun Nigeria, conventional method was used to cured it by wrapping it in clean leaves of banana to decrease the quantity of moisture lost and after that set aside for fourteen days in the laboratory before used. Association of Official Analytical Chemists (AOAC) 1984 methods was used to carry out proximate analysis of the species. The results obtained showed that   Cola nitida had (60.80%), moisture, (2.94%) ash, (7.91%) crude protein, and (2.70%) caffeine. Cola accuminata had   (56.30%) moisture, (3.04%) ash, (8.68%), crude protein and (2.75%) caffeine, while Garcinia Kola had (51.30%) moisture, (2.95%) ash, (8.90%) crude protein and (2.96%) caffeine. 
Uchenna Nwabunwanne Eze, Ugwu Chukwuebuka V, Onuoha Maxwell, Ubenyi Stanley M
Journal of Chemistry and Nutritional Biochemistry, Volume 2, pp 1-27; https://doi.org/10.48185/jcnb.v2i2.283

Abstract:
In Nigeria, rural inhabitants often resort to herbal remedies and dietary control for the treatment and management of various forms of diabetes mellitus. This study was conducted to provide the rationale for the use of Psidium guajava leaves as a potent traditional anti-diabetic remedy. The crude leaf extracts of n-hexane, methanol, and ethyl acetate of Psidium guajava were separately prepared by cold maceration. Then, ethyl acetate crude extract of Psidium guajava leaves was fractionated by column chromatography to yield ethyl acetate bulked fractions: EF-I (1-75), EF-II (76-150), and EF-III (151-250). The n-hexane, ethyl acetate, and methanol crude leaf extracts and ethyl acetate bulked fractions (EF-I, EF-II and EF-III) were evaluated for anti-diabetic activity in alloxan-induced diabetic mice. The blood sugar levels of treated and untreated alloxan-induced diabetic mice were assayed as indices of anti-diabetic effect. The phytochemical constituents of both crude extracts and ethyl acetate fractions of Psidium guajava leaves and the mean lethal dose (LD50) of ethyl acetate crude leaf extract of Psidium guajava were determined. The mean lethal dose (LD50) of ethyl acetate crude leaf extract was calculated to be 1500mg/kg b.w. The results indicated that oral administration of ethyl acetate, n-hexane, methanol crude extracts, and ethyl acetate bulked fractions of Psidium guajava leaves at a dose of 100mg/kg b.w on treated groups exhibited much significant[p<0.001, p<0.01and p0.05] anti-hyperglyceamic activity for the reduction in blood sugar levels compared with the negative and positive control groups. The anti-diabetic potency of the crude leaf extracts and ethyl acetate fractions were in the order; EC>HC>MC>EF-I>EF-II>EF-III. The results of phytochemical screening of the crude extracts and ethyl acetate bulked fractions showed the presence of tannins, flavonoids, saponins, alkaloids, terpenoids, glycosides, and steroids while reducing sugar was absent. The results from this study gives credence to the use of Psidium guajava as an anti-diabetic agent in the management of diabetes mellitus.
, Munir Ullah Khan
Journal of Chemistry and Nutritional Biochemistry, Volume 2, pp 35-45; https://doi.org/10.48185/jcnb.v2i2.378

Abstract:
The non-coding elements that control transcription are found in the chromatin structure of organisms. Recent findings identify the non-coding regulatory elements (e.g., enhancers, silencers, promoters) that control transcription and examine their respective protein interactions. The multiple topological environment limitations, including interactions of promoter-enhancer and specific enhancer-bound proteins with variable promoter compatibility, begin to shape a picture. These transcription factors and co-factors contribute to various expressions based on which enhancers and promoters are found inside sequences. A novel trait of transcription factors and co-factors establishes nuclear microenvironments or membranes compartments with phase-separated liquid characteristics. These settings are capable of enriching some proteins and tiny molecules at the expense of others. To better understand gene regulation
Journal of Chemistry and Nutritional Biochemistry, Volume 2, pp 28-34; https://doi.org/10.48185/jcnb.v2i2.230

Abstract:
This study deals with the in-vitro experimental analysis of different generic antibiotics and season based honey, sensitivity against isolated bacteria. The characterization of bacteria isolated from the frozen hilsa is done through various biochemical reactions The antibacterial sensitivity of honey and antibiotics are evaluated through zone of inhibition analysis of bacterial colony. So, it is obvious that this experiment provides providential values for future research including food value analysis.
Journal of Chemistry and Nutritional Biochemistry, Volume 2, pp 59-69; https://doi.org/10.48185/jcnb.v2i2.387

Abstract:
The mitochondria perform an essential role in cellular metabolism by acting as a cellular energy powerhouse. It is also involved in several biological processes such as cell metabolism, stress signaling, calcium homeostasis, and reactive oxygen species(ROS) and apoptosis. Maintaining cellular physiological function is strongly dependent on mitochondrial quality control. mitochondrial malfunction will lead to various disorders. For this review, we evaluate the current understanding of the molecular mechanism of mitochondria quality control, which might also serve as an asset for organisms' health and the prevention of disease
Mohammad Siddique, Suhail Ahmed Soomro, Hijaz Ahmad, Gull Karam Khan
Journal of Chemistry and Nutritional Biochemistry, Volume 2, pp 46-58; https://doi.org/10.48185/jcnb.v2i2.408

Abstract:
Global energy security, as well as environmental concerns, are major motivators for increased biomass usage around the world, especially in developing countries like Pakistan. Developing countries are experiencing a severe energy shortage. To fulfill its energy needs, the country spends about $7 billion per year on fossil fuel important benefits from nearly 159 million animals producing nearly 652 million kg of manure per day, which can be used to generate 16.3 million m3 biogas per day and 21 million tons of biofertilizer annually. In the year 2000, the Pakistani government launched the Biogas Support Program (BSP). It has already installed 1200 biogas units and plans to install another 10,000 in the next five years, Nearly a quarter of the country's biogas capacity comes from this area. The cost of conventional fuel is projected to be 92,062 PKR per year for a biogas unit with a 10 m3 range. The implementation of biogas units is said to have increased women's opportunity costs, resulting in a positive effect on household income. The demand for biogas renewable energy systems is strong, and the number of these systems is steadily increasing. They are simple to implement and can be completed on a shoestring budget. For the 70% of the country's population who live in rural areas, a biogas energy corridor may be a viable alternative. An additional alternative is to build plants to bottle biogas. The government should formulate a policy that allows for the delivery of this technology to farmers' doorsteps. The article outlines the overall progress on Pakistan's existing biogas use scenario, as well as the potential for biogas and fertilizer, as well as the economic advantages of biogas over conventional fuels. This is the first time anything like this has happened, and it's great to see findings announced with such precision.
S. Azhagu Madhavan
Journal of Chemistry and Nutritional Biochemistry, Volume 2, pp 29-38; https://doi.org/10.48185/jcnb.v2i1.167

Abstract:
Azadirachta indica phytochemicals are found to be effective against malignant growth and hostile to bacterial properties. In the specific examination, the coupling proficiency of five mixes that are available in the Azadirachta indica with all the eleven proteins through in silico techniques was completed. Plant removes harmful compound instigated injury by expanding the body's degrees of cell reinforcement particles. For example, they affect the glutathione, and improving the action of cancer prevention agent chemicals. About 549 cells treated with Azadirachta indica ethanolic separated in various hours (6, 12, 24 and 36 hours). After 36 hours, the cells development was controlled. There are re-established interests in home grown based meds to hinder the results of manufactured medications, Azadirachta Indica L. A leaf contains phytochemical intensifies that has all freer revolutionary rummaging just as anticancer exercises.
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