International Journal of Preclinical and Clinical Research

Journal Information
EISSN : 2583-0104
Total articles ≅ 53

Latest articles in this journal

S R Samhitha, H T ​ Tejasvi, G Prashanth
International Journal of Preclinical and Clinical Research, Volume 3, pp 64-65;

Kikuchis disease is a rare, self limiting disease characterized clinically by fever with tender regional lymphadenopathy with characteristic histopathological features on lymph node biopsy. It is a rare disease with unkown incidence with very few reported cases. It is most prevalent in young asian population equally affecting both the sexes. The disease is usually self limiting ,in rare cases complications such as aseptic meningitis, cerebellar ataxia, encephalitis, myocarditis, acute renal failure can occur. We report a case of 28 year old male presented with fever and generalized lymphadenopathy with features suggestive of myocarditis. Keywords: Kikuchi disease, lymphadenopathy, myocarditis
Shivashankar Biradar, K C Shivakumara, G H ​ Megha
International Journal of Preclinical and Clinical Research, Volume 3, pp 61-63;

A 45-year-old female presented with complaints of headache and lower limb weakness since 3 months before admission to the hospital and slurring of speech. Patient was known hypertensive with a blood pressure of 130/80 mmhg, a regular pulse rate of 90 times/min, a breath rate of 18 times/min, and an oxygen saturation of 98%. Mallampati 1, good flexion and extension movements of the neck and temporomandibular joints. Keywords: Meningioma, Munroe Kellies Law, Neuro-anaesthesia, Parasagittal Tumour
H K Shreekrishna, S Mohan ​ Kumar
International Journal of Preclinical and Clinical Research, Volume 3, pp 66-68;

A medical record is a confidential compilation of pertinent facts of an individual’s health history, including all past and present medical conditions, illnesses and treatment, with emphasis on the specific events affecting the patient during the current episode of care. The information documented in the health record is created by all healthcare professionals providing care and is used for continuity of care. It reflects and creates excellence in medical care and of Standards of Care. Documentation is legal protection for both patient and physician in the dispute over care. Failure to document important details can lead to adverse patient outcomes and malpractice suits. Keywords: Confidentiality, consent, documentation
Muganagowda Patil, K B Chethan, Mallisetty Narasinga ​ Raj
International Journal of Preclinical and Clinical Research, Volume 3, pp 56-60;

Sjogren-Larsson syndrome (SLS) is a rare autosomal recessive lipid metabolic disorder caused because of the defect in fatty alcohol oxidation resulting from fatty aldehyde dehydrogenase (FALDH3A2) deficiency. Sjogren-Larsson syndrome is constituted by the trio of generalised spastic paralysis, intellectual impairment, & ichthyosis. The inability of hydrogen ions secretion from the distal tubule characterises dRTA (distal (Type 1) renal tubular acidosis). The dRTA aetiology is diverse, but it can be acquired or inherited. We report siblings who presented with congenital ichthyotic hyperkeratosis, spastic diplegia and severe learning disabilities, which were suggestive of SLS. Distal renal tubular acidosis diagnosis was done on the basis of severe serum hypokalaemia, urine electrolytes showing high potassium levels, metabolic acidosis with a positive anion gap, high pH of urine, Urinary & Blood PCO2 difference (UB PCO2) on the lower side, (FeHCO3%) showing mild bicarbonaturia (<5%), medullary nephrocalcinosis, Hypercalciuria as well as the omission of other differential diagnosis. Management in SLS was supportive. The child demonstrated symptomatic improvement after starting standard therapy for SLS & distal renal tubular acidosis. To conclude, distal renal tubular acidosis ailment in children can be controlled with a good long-term prognosis, but precise diagnosis as well as management are critical. Early detection can assist the physician in implementing appropriate supportive care as well as possible curative gene therapy. Keywords: Ichthyosis, spastic diplegia, Intellectual disability, Distal Renal Tubular Acidosis, Hypokalaemia
N B Prahlada, S Raisa
International Journal of Preclinical and Clinical Research, Volume 3, pp 31-36;

Unilateral Vocal cord palsy typically presents with dysphonia, shortness of breath and swallowing difficulty. It can be iatrogenic, idiopathic or may occur secondary to damage to recurrent laryngeal nerve following trauma, impinging mass lesions, neurological disorders or neuro-musculoskeletal diseases, or infectious in aetiology. To study and compare the effects of Type I Thyroplasty depending on the time of presentation, that is, early and delayed presentation. Ambispective Study Design. Our study included 32 patients who presented to our Institution with history of dysphonia, diagnosed with unilateral vocal cord palsy. Depending on the duration of symptoms on presentation, patients were categorised into 2 groups, which is early subgroup who presented within 1 year of symptom onset, 21 patients and delayed subgroup who presented after 1 year of symptom onset, 11 patients. Complete preoperative evaluation including perceptual analysis of voice quality, acoustic measures of voice quality, Aerodynamic measures of voice quality, quality of life measure, tele laryngoscopy was done. All patients underwent Type I Thyroplasty and were followed up at 2 weeks, 1 months, 3 months and 6 months, with follow up criteria including perceptual analysis of voice, MPT and VHI-10. Out of 32 patients, Male to female ratio was 26 : 6, with mean age of presentation being 47 years. The laterality of the palsy was R: L → 4: 28. When compared to the Delayed subgroup, early Subgroup had significant improvement in outcomes with respect to GRBAS Scale, VHI-10 and MPT. Keywords: Unilateral vocal cord palsy, Early & Delayed
G Prashanth, Murtuza Kauser, Basavaraj Savadi, B M ​ Rashmi
International Journal of Preclinical and Clinical Research, Volume 3, pp 37-44;

The usefulness of risk screening tools in triaging and predicting likelihood of adverse outcomes of COVID-19 patients at first point of contact, would prevent overestimation or underestimation of severity risk in COVID pneumonia. BCRSS algorithm, a dynamic risk predictor, that uses clinical parameters of patient to assess need for escalating levels of respiratory support(Non-invasive ventilation, intubation, proning) to suggest treatment recommendations. Quick COVID-19 Severity Index (qCSI) is based on 3 variables (nasal cannula flow rate, respiratory rate, minimum documented pulse oximetry). To compare prognostic performance of BCRSS and qCSI-scores of hospitalized patients diagnosed with COVID-19. This is a Retrospective record-based study conducted at a tertiary hospital in Karnataka among COVID-19 patients. Patient’s clinical severity grade classification was done according to standard guidelines by Government of India. BCRSS and qCSI scores were calculated using baseline clinical information of patients. Statistical analysis used were Chi-squared test, regression analysis and ROC curve. The study results showed that out of 363 patients, majority of patients with high qCSI risk score of 3 and those with high BCRSS risk score of 4 were found to have high rates of ICU admissions and in-hospital deaths (66.9% and 44.4% for qCSI-3; 34.6% and 1.9% for BCRSS-4). With every unit increase in qCSI and BCRSS scores, there were 2.68 and 1.58 times more risk of fatality respectively. ROC curves for qCSI and BCRSS scales showed high area under curve:qCSI(AUC:0.761) and BCRSS(AUC:0.760), to predict in-hospital fatality. The study has shown that both qCSI and BCRSS scoring models have good results for predicting probabilities of ICU admissions and in-hospital mortality of COVID-19 patients. Key Messages: These risk prediction models, if applied during the initial clinical assessment stage, could help in better triaging, risk prediction, better treatment of COVID-19 patients. Keywords: Quick COVID-19 Severity Index, Brescia-COVID Respiratory Severity Scale, in-hospital mortality, COVID-19, ICU admission
Bhagyalaxmi Sidenur, A M Amrutha, Vijayalaxmi ​ Mangasuli, S B Vijeth, Deepa Patil, M R Nagendragowda
International Journal of Preclinical and Clinical Research, Volume 3, pp 45-48;

India leads the world with the most number of diabetic subjects earning the dubious distinction of being termed the “Diabetes capital of the world”. Approximately half of all subjects with diabetes in the developing world remain undiagnosed and untreated leading to serious long term consequences. A cross-sectional study was done in urban field practice area of Basaveshwar Medical College among adults >20 years of age with sample size of 20. Systematic random sampling was used to select the subjects. Data was collected using standardised questionnaire which included socio-demographic profile, standard glucometer was used to measure random blood glucose for all participants. IDRS was used to ascertain the risk of developing diabetes. Data was analysed using Pearson’s Chi square test and Fischer exact. The overall prevalence of diabetes was 11%. Among 191 subjects, 4.2% were in low risk category. 42.9% and 52.8% were in moderate and high risk category respectively. Total of 8 subjects were newly diagnosed in our study. Among them 7 subjects were in the high risk category and 1 was in the low risk category. This study estimates the usefulness of simplified Indian Diabetes Risk Score for identifying high risk for diabetes in the community. It should be used routinely in community-based screening to find out high risk category of population for diabetes. Keywords: IDRS, Risk for diabetes, Socio­demographic factors
Mallisetty Narasinga Raj, Gayathri H Aradhya, Chaitali Raghoji
International Journal of Preclinical and Clinical Research, Volume 3, pp 49-55;

Sepsis is an important cause of morbidity and mortality among neonates. Neonatal sepsis can alter the glucose level, and both hypoglycaemia and hyperglycaemia may occur. Hence the present study aimed to study the clinical profile of patients with neonatal sepsis and to correlate the blood sugar levels with different outcomes in neonatal sepsis patients. A cross-sectional study was conducted at Bapuji Child Health Institute and Research Institute attached to J.J.M. Medical College, Davangere. A total of 90 neonates under the age of 28 days old admitted to NICU with probable and culture-proven neonatal sepsis were included in the study. Glucose levels, complete blood count, CRP levels, septic screening, lumbar puncture, neurosonogram, urine culture, blood culture and sensitivity were analysed. Results revealed that GRBS scores were < 40 for 24 subjects, 41 to 100 for 39 subjects, 101 to 200 for 22 subjects and > 200 for 5 subjects. There were 57(63.3%) males and 33(36.7%) females in the clinically diagnosed cases of septicemia. Clinical presentation in sepsis showed that 82(91.1%) subjects were not feeding well, 19(21.1%) had convulsions, 51(56.7%) had fast breathing, 39(43.3%) had Severe chest indrawing, 25(27.8%) had a temperature, 43(47.8%) had a fever and 88(97.8%) had Decreased activity of admission. In Conclusion, alteration of glycaemic status occurred in septic newborns, and mortality was higher among septic newborns with altered glycaemic status. Keywords: Neonatal sepsis, GRBS, Hypoglycaemia, Hyperglycaemia, Mortality
Rahul Jain, B V Sharath, Suresh U Kadli, Kiran Badiger
International Journal of Preclinical and Clinical Research, Volume 3, pp 22-24;

Gastrointestinal Stromal Tumors (GISTs) were originally believed to have originated from the mesenchymal cells of the gastrointestinal tract. These tumors actually originate from the intestinal cells of Cajal. A 26-year-old female came with complaints of mass per abdomen since 3 months which was insidious in onset, slowly progressive, complaining of vomiting,3-4 episodes since the last 4 days, non-blood tinged,non-projectile,non-bilious,non-foul smelling containing food particles associated with pain in the upper abdomen dull aching type,non-radiating, and non-migrating. On per abdominal examination — There was an oval-shaped mass that was firm in consistency, measuring about 15x10cm in size located in the left lumbar extending into the umbilical area which was mobile horizontally but vertical mobility was restricted. Routine investigations, USG, and CECT abdomen & pelvis were done which was pointing the diagnosis towards mesenteric GIST. Exploratory laparotomy and resection of GIST were scheduled. The resected tumor was sent for histopathological examination and a CD-117(IHC) marker was sent, which confirmed the mass as a mesenteric GIST. Literature shows that only a few cases of mesenteric GIST have been reported to date. Incidence of such giant mesenteric GISTs is very rare and intestinal preserving giant mesenteric gist excision is one of the firsts. Keywords: Mass per abdomen, Mesenteric GIST
S Geetha, Deepa Patil
International Journal of Preclinical and Clinical Research, Volume 3, pp 7-10;

This study aims to evaluate the drug utilization pattern in terms of defined daily dose (DDD) among geriatric patients admitted in medical intensive care unit (MICU) of a tertiary care hospital. Retrospective medical record analysis was performed for the geriatric patients (age ≥65 years) admitted in MICU from 1st June 2021 and 31st December 2021. The relevant data were collected in a proforma. The drugs were categorized by anatomical therapeutic classification and their DDD was calculated. Diabetes mellitus was the most common cause for admission. Parenteral preparations (51.12%) constituted the largest share among all the drugs prescribed. Pantoprazole - A02BC02 with DDD 25.3 was the most commonly prescribed parenteral drug (23.5%). Amlodipine - C08CA01 with DDD 29.0 was the most commonly prescribed oral drug (27.6%). Average number of drugs per patient was 10.37±0.27. Average number of antimicrobials prescribed per patient was 1.26±0.09. Ceftriaxone was the commonly prescribed antimicrobial drug. This study shows the most common causes of admission among geriatric patients in MICU setup and the pattern of drugs used. Drug utilization studies of this type may ultimately help in improving the quality of healthcare given to the geriatric patients. Keywords: Geriatric patients, Anatomical therapeutic chemical classification, Drug utilization pattern, Defined daily dose system
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