Recent Trends in Pharmaceutical Sciences and Research

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Vikrant Dalwal, Priyakul Palia, Shivali Singla, Sachin Goyal
Abstract:
Quinoline has recently become an important heterocyclic compound due to its diverse applications in industrial and synthetic organic chemistry. It is an important scaffold for leads in drug discovery and plays an important role in medicinal chemistry. There are numerous articles now reporting on its functionalization for biological and pharmaceutical activities. Quinoline, also known as 1-aza-naphthalene, is a weak tertiary base. Quinoline ring has antimalarial, antibacterial, antifungal, anthelmintic, cardiotonic, anticonvulsant, anti-inflammatory, and analgesic activity. Quinoline not only has a diverse set of biological and pharmacological activities, but it also has a number of well-established protocols for its synthesis. The purpose of this article is to highlight the ring's diversity.
Km. Roshani, Mangla Nand Singh, D. Sasmal, P. D. Panda, Jai Narayan Mishra, Reena Singh
Published: 22 November 2021
Abstract:
Etoricoxib belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). Etoricoxib acts by reducing the pain and swelling (inflammation) in the joints and muscles of people older than 16 years of age and older patients with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and gout. The present study was aimed to formulate fast dissolving oral films to enhance bioavailability, avoid presystemic metabolism and fast onset of action. The Preformulation studies such as Micromeritics, melting point, partition coefficients, UV spectroscopy, thin layer chromatography, loss on drying were carried out. The fast dissolving oral film was successfully fabricated by solvent casting method. Oral film was fabricated using PVA and PVP polymer. The prepared films were evaluated for Organoleptic evaluations, film weight, thickness, folding endurance, tensile strength, drug content uniformity of films, surface pH, disintegration time and in-vitro dissolution studies and SEM study. The formulation F8 has shown disintegration time of 22±1 seconds and is more promising, showed drug release in phosphate buffer 6.8 pH 86.33% in 10 min. Hence formulation F8 was selected as best formulation. In the stability testing all films stored at elevated temperature showed slight change in pH, other parameters were found to be unchanged.
Avisek Dutta
Abstract:
Approximately 30% of the world's population suffers from pain. Pain increases to 50% in those older than 65 years. Multidisciplinary treatment is important parameter in the treatment of both acute and chronic pain. 15% patients generally do not use medications. 35 % patients undergo Non-pharmacological pain therapy which refers to interventions which do not involve the use of medications to treat pain. These methods have virtually no adverse reactions, though have lesser efficacy than pharmacotherapy. Pain experience is reported by 91% to 94% of patients undergoing orthodontic treatment. Low back pain (LBP)-pain experienced in the lumbosacral spinal and paraspinal regions, including the buttocks and upper thigh-is seen in nearly 20% patients.
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