ISSN / EISSN : 2036-7392 / 2036-7406
Published by: PAGEPress Publications (10.4081)
Total articles ≅ 261
Latest articles in this journal
Dermatology Reports; https://doi.org/10.4081/dr.2022.9339
Demodex mites are common ectoparasites of the human pilosebaceous units. Most adults are infested with Demodex mites without clinical symptoms. Demodex mite will only become a pathogenic organism when there is an abnormal increase in the number of Demodex mite density. This situation happens when the equilibrium between Demodex mites, skin microenvironment and human immunity system changes. Demodex infestation can cause multiple skin disorders, which are grouped under the term demodicosis or demodicidosis. Clinical manifestations of demodicosis can mimic other known skin diseases such as folliculitis, rosacea, perioral dermatitis, which is why it is often misdiagnosed. Diagnosis criteria consists of relevant correlation of suspected clinical skin lesions, confirmed by the presence of abnormal proliferation of Demodex mites and by clinical cure after acaricidal treatment together with normalization of Demodex mite density. Dermatologists should be aware that demodicosis is not an uncommon skin disease, and there are still many unknowns about it that should be researched further.
Dermatology Reports; https://doi.org/10.4081/dr.2022.9306
Various options are available for the reconstruction of full-thickness defects of the nasal ala with different advantages and disadvantages, but none are fully satisfactory. We present the case of a 57- year-old man with a recurrent basal cell carcinoma of the right nasal ala and nearby cheek and upper lip. Tumour clearance was achieved after two stages of ‘fresh/frozen’ Tübingen technique, resulting in a 2.0 x 2.0 cm full-thickness defect of the lateral right ala. The wound involved the alar rim, groove and adjacent check and upper lip. Reconstruction was successfully achieved with a nasolabial turnover flap (modified Spear flap) in a single stage. The surgical procedure and subsequent outcomes are illustrated. Our experience shows the effectiveness of the nasolabial turnover flap for a single-stage repair of full-thickness defects of the nasal area and adjacent tissue.
Dermatology Reports; https://doi.org/10.4081/dr.2022.9337
Late-onset focal dermal elastosis is a rare cutaneous condition classified within the disorders of increased dermal elastic tissue. It is characterized clinically by multiple papules with predilection for the neck and other flexures, without systemic alterations, and histologically by focally increased elastic fibers in the reticular dermis. Several elastic tissue disorders share a similar clinical presentation in the skin. Distinction of late-onset focal dermal elastosis and other pseudoxanthoma elasticum mimickers from pseudoxanthoma elasticum is critical, as they are not associated to systemic lesions. We report here on a case of late-onset focal dermal elastosis and review the scientific literature on this unusual condition.
Dermatology Reports; https://doi.org/10.4081/dr.2022.9474
Occupational skin-related problems include dermatoses caused by agents in the working environment. For health care workers, these occupational dermatoses could be due to usage of personal protective equipment (PPE), such as gloves, masks, goggles, and other protective equipment. These PPE contribute to both allergic and irritant contact dermatitis. This review summarized the skin damage after PPE usage and hand hygiene protocol. Recommendations should be established to prevent these occupational dermatoses from PPE usage.
Dermatology Reports; https://doi.org/10.4081/dr.2022.9259
The use of multiple drugs acting as modulators of the immune system are common among patients with severe autoimmune diseases. In these clinical scenarios, great attention should be placed on diagnosing infective cutaneous disorders that can underly iatrogenic immunosuppression. Here within, we report a rare case of molluscum contagiosum eruption on the face and the scalp during an immunomodulating treatment for rheumatoid arthritis, with clinical and dermatoscopic characterization.
Dermatology Reports; https://doi.org/10.4081/dr.2022.9492
Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a variant of pityriasis lichenoides et varioliformis acuta (PLEVA). Although rare, the condition may progress to involve serious complications and even lead to fatal outcomes if diagnosis and appropriate treatment is delayed. A PubMed search following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRIMSA) guidelines was performed to find cases of FUMHD from the earliest records to October 2021. Treatments, complications, and patient outcomes were extracted from the literature and summarized, while a review of quality was also performed. A total of 63 publications with 68 patients were found. Successful treatment modalities for FUMHD included antibiotics, antivirals, systemic steroids, methotrexate (MTX), cyclophosphamide, cyclosporine (CYA), intravenous immunoglobulins (IVIG), pentoxifylline, and ultraviolet B phototherapy. Out of 68 patients, 55 patients had their condition fully resolved and 13 cases were fatal. Increased age, systemic involvement, and monoclonal T-cell receptor rearrangement were associated with worst prognosis, but mucosal involvement did not affect mortality risk. Overall, the publications had low risk of bias, but most lacked adequate follow-up periods. FUMHD is a diagnostic and therapeutic challenge due to the lack of clearly defined diagnostic criteria and optimum treatment. Further studies with larger patient populations and longer follow-up periods may lead to refinement of diagnostic criteria, establish an optimum treatment regimen, and better estimate the likelihood of recurrence.
Dermatology Reports; https://doi.org/10.4081/dr.2022.9426
Introduction: Anthrax is a zoonotic disease caused by Bacillus anthracis which is transmitted to humans from infected animals. Transmission occurs when there is contact with animals or products from animals infected with anthrax. Anthrax infection is an important public health problem in developing countries. Indonesia is one of the countries where zoonotic anthrax forms can still be found. The most common entrance route for anthrax spores is the skin. Although skin anthrax usually resolves on its own, complications can arise in untreated cases. Underlying systemic disorders such as diabetes mellitus can disrupt the clinical picture and cause atypical presentation. Case Presentation: A 50-year-old woman who works as a farmer with a history of diabetes mellitus, is treated at a local hospital with complaints of fever and inflamed lesions in the lower right leg. An anthrax outbreak has been reported in the area where she lives. At clinical examination regional swelling was found and the appearance of blackish lesions accompanied by pus around the wound. Laboratory tests documented by ELISA an increased titre of anthrax antibodies. The patient was given antibiotic therapy with a combination of penicillin G and ciprofloxacin intravenously and experienced healing from skin lesions. Conclusion: Comorbid diseases such as diabetes mellitus can obscure clinical manifestations of skin anthrax and causes systemic symptoms. With appropriate management, skin anthrax lesions in patients with comorbid diabetes mellitus can heal with good results.
Dermatology Reports; https://doi.org/10.4081/dr.2022.9341
Background: Hair disorder has severe impacts on sociopsychology aspects. Currently, there are limited and outdated studies related to hair disorders in Indonesia. Aims: Our study aimed to provide an update regarding the epidemiology of hair loss commonly occurring in Indonesia Methods: This is a retrospective study that review hair disorder cases at the Cosmetic Dermatology Outpatient Clinic dr. Cipto Mangunkusumo National Central General Hospital between January 2017 to December 2019. Age, gender, family history, education, occupation, body mass index (BMI), comorbidities, and diagnosis of each patient were recorded. Results: From the 64 patients who were eligible for the study, hair disorders was found to be more prevalent in male 54.6% with a mean age of 26.41 + 12.8 years old and the highest age group of 18-39 years old 59.4%. There were 32 cases (50.0%) of alopecia areata (AA), 20 cases (31.2%) of alopecia androgenetic (AGA), 9 cases (14.0%) of telogen effluvium (TE), 2 cases of cicatricial alopecia (CA) due to lupus erythematosus (DLE) and 1 trichotillomania (TTM). Cases of TE were significantly higher in female patients. Cases of AGA in the study, mainly early-onset AGA (mean age 29.45 + 10.29 years old, 39.5% in 18-39 years old) showed a significant positive familial history. Conclusions: The most frequent type of hair disorder at dr Cipto Mangunkusumo National General Hospital Jakarta were AA, AGA, and TE, respectively with each disease showing a different socio-demographic and clinical profile.
Dermatology Reports; https://doi.org/10.4081/dr.2022.9487
Tumors of the scalp remain a serious challenge for clinicians since poor locoregional skin elasticity hinders the ability to utilise certain flaps, limiting the choice of reconstructive techniques available. As a result, surgical restoration of medium to large-sized defects are left to the discretion of the surgeon, who with a comprehensive knowledge of restorative techniques, along with the advantages, limitations as well as a sound understanding of the locoregional anatomy, can make thorough decisions on the choice of which flap is best suited for the defect. Here we present two cases where the double hatchet flap was employed as a dermatosurgical approach in order to provide exceptional cosmetic results. On dermatological examination, both patients presented with a medium to large- sized tumour formation but were otherwise in good health. Both underwent radical, widelocal excision, followed by reconstructive manipulation in the form of a double hatchet flap to close the defect. Postoperative follow-up reported positive signs of wound healing with aesthetically pleasing results. Finally, we discuss the use of various flaps in such conditions while providing evidence for the double hatchet flap as a possible alternative that provides perfect aesthetic results as seen in our cases. Such a complex surgical intervention requires the expertise of a multidisciplinary team in order to achieve an overall successful outcome.
Dermatology Reports; https://doi.org/10.4081/dr.2022.9265
Etanercept is approved for continuous or intermittent use and flexible dosing in plaque psoriasis (PsO). The objectives of this study were to investigate real-world treatment patterns with etanercept in Greek adults with moderate-to-severe PsO. This non-interventional multicenter study included a retrospectiveto- prospective (RP) cohort, previously treated with etanercept for ≥24 months and followed for an additional 6 months, and a biologic-naïve, prospective-only (PO) cohort, followed for 6 months after treatment initiation. Parameters assessed included Psoriasis Area and Severity Index (PASI), percentage of body surface area (BSA) affected, Dermatology Life Quality Index (DLQI), and adverse events (AEs). This study enrolled 123 patients (RP, n = 56; PO, n = 67), who mostly adhered to continuous treatment (RP, 68%; PO, 95%). The two cohorts had similar mean baseline-to-endpoint decreases in PASI (-9.5 vs -10.1) and BSA (-11.9 vs -12.3). The PO-CTP population had a mean DLQI baseline-to-endpoint score decrease of -5.8, which was statistically significant and clinically meaningful. Treatment-emergent AE rates were 58.9% (RP) versus 26.9% (PO). These real-world data suggest a similar effectiveness of continuous and intermittent etanercept treatment in Greek patients with PsO.