ISSN / EISSN : 2198-3844 / 2198-3844
Published by: Wiley-Blackwell (10.1002)
Total articles ≅ 3,617
Latest articles in this journal
Advanced Science; https://doi.org/10.1002/advs.202100870
Multicomponent high-entropy alloys (HEAs) can be tuned to a simple phase with some unique alloy characteristics. HEAs with body-centered-cubic (BCC) or hexagonal-close-packed (HCP) structures are proven to possess high strength and hardness but low ductility. The faced-centered-cubic (FCC) HEAs present considerable ductility, excellent corrosion and radiation resistance. However, their strengths are relatively low. Therefore, the strategy of strengthening the ductile FCC matrix phase is usually adopted to design HEAs with excellent performance. Among various strengthening methods, precipitation strengthening plays a dazzling role since the characteristics of multiple principal elements and slow diffusion effect of elements in HEAs provide a chance to form fine and stable nanoscale precipitates, pushing the strengths of the alloys to new high levels. This paper summarizes and review the recent progress in nanoprecipitate-strengthened HEAs and their strengthening mechanisms. The alloy-design strategies and control of the nanoscale precipitates in HEAs are highlighted. The future works on the related aspects are outlined.
Advanced Science, Volume 8; https://doi.org/10.1002/advs.202170136
Proteolysis-Targeting Chimera Technology
Advanced Science; https://doi.org/10.1002/advs.202101166
Lipid-based nanoparticles have been applied extensively in drug delivery and vaccine strategies and are finding diverse applications in the coronavirus disease 2019 (COVID-19) pandemic—from vaccine-component encapsulation to modeling the virus, itself. High-throughput, highly flexible methods for characterization are of great benefit to the development of liposomes featuring surface proteins. DNA-directed patterning is one such method that offers versatility in immobilizing and segregating lipid-based nanoparticles for subsequent analysis. Here, oligonucleotides are selectively conjugated onto a glass substrate and then hybridized to complementary oligonucleotides tagged to liposomes, patterning them with great control and precision. The power of DNA-directed patterning is demonstrated by characterizing a novel recapitulative lipid-based nanoparticle model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—S–liposomes—that presents the SARS-CoV-2 spike (S) protein on its surface. Patterning a mixture of S–liposomes and liposomes that display the tetraspanin CD63 to discrete regions of a substrate shows that angiotensin-converting enzyme 2 (ACE2) specifically binds to S–liposomes. Subsequent introduction of S–liposomes to ACE2-expressing cells tests the biological function of S–liposomes and shows agreement with DNA-directed patterning-based assays. Finally, multiplexed patterning of S–liposomes verifies the performance of commercially available neutralizing antibodies against the two S variants. Overall, DNA-directed patterning enables a wide variety of custom assays for the characterization of any lipid-based nanoparticle.
Advanced Science, Volume 8; https://doi.org/10.1002/advs.202170135
Spatial Micro-Water Manipulation
Advanced Science, Volume 8; https://doi.org/10.1002/advs.202170133
Epigenome-Wide Association Study
Advanced Science, Volume 8; https://doi.org/10.1002/advs.202170131
Oligodendrocyte Precursor Cells
Advanced Science, Volume 8; https://doi.org/10.1002/advs.202103927
Advanced Science, Volume 8; https://doi.org/10.1002/advs.202170132
Advanced Science; https://doi.org/10.1002/advs.202102097
Introducing artificial strain in epitaxial thin films is an effective strategy to alter electronic structures of transition metal oxides (TMOs) and to induce novel phenomena and functionalities not realized in bulk crystals. This study reports a breaking of the conventional trade-off relation in thermopower (S)–conductivity (σ) and demonstrates a 2 orders of magnitude enhancement of power factor (PF) in compressively strained LaTiO3 (LTO) films. By varying substrates and reducing film thickness down to 4 nm, the out-of-plane to the in-plane lattice parameter ratio is controlled from 0.992 (tensile strain) to 1.034 (compressive strain). This tuning induces the electronic structure change from a Mott insulator to a metal and leads to a 103-fold increase in σ up to 2920 S cm−1. Concomitantly, the sign of S inverts from positive to negative, and both σ and S increase and break the trade-off relation between them in the n-type region. As a result, the PF (=S2σ) is significantly enhanced to 300 µW m−1K−2, which is 102 times larger than that of bulk LTO. Present results propose epitaxial strain as a means to finely tune strongly correlated TMOs close to their Mott transition, and thus to harness the hidden large thermoelectric PF.
Advanced Science, Volume 8; https://doi.org/10.1002/advs.202170137