Immunological Reviews

Journal Information
ISSN / EISSN : 0105-2896 / 1600-065X
Current Publisher: Wiley (10.1111)
Former Publisher: Wiley (10.1034) , Wiley (10.1046)
Total articles ≅ 4,007
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Latest articles in this journal

Published: 24 January 2021
by Wiley
Immunological Reviews; doi:10.1111/imr.12947

The publisher has not yet granted permission to display this abstract.
Aravind Cherukuri, Kanishka Mohib, David M. Rothstein
Published: 22 January 2021
by Wiley
Immunological Reviews; doi:10.1111/imr.12933

Abstract:
Regulatory B cells (Bregs) ameliorate autoimmune disease and prevent allograft rejection. Conversely, they hinder effective clearance of pathogens and malignancies. Breg activity is mainly attributed to IL‐10 expression, but also utilizes additional regulatory mechanisms such as TGF‐β, FasL, IL‐35, and TIGIT. Although Bregs are present in various subsets defined by phenotypic markers (including canonical B cell subsets), our understanding of Bregs has been limited by the lack of a broadly inclusive and specific phenotypic or transcriptional marker. TIM‐1, a broad marker for Bregs first identified in transplant models, plays a major role in Breg maintenance and induction. Here, we expand on the role of TIM‐1+ Bregs in immune tolerance and propose TIM‐1 as a unifying marker for Bregs that utilize various inhibitory mechanisms in addition to IL‐10. Further, this review provides an in‐depth assessment of our understanding of Bregs in transplantation as elucidated in murine models and clinical studies. These studies highlight the major contribution of Bregs in preventing allograft rejection, and their ability to serve as highly predictive biomarkers for clinical transplant outcomes.
Published: 12 January 2021
by Wiley
Immunological Reviews; doi:10.1111/imr.12938

The publisher has not yet granted permission to display this abstract.
Published: 7 January 2021
by Wiley
Immunological Reviews; doi:10.1111/imr.12940

The publisher has not yet granted permission to display this abstract.
Madhvi Menon , Tracy Hussell, Halima Ali Shuwa
Published: 6 January 2021
by Wiley
Immunological Reviews; doi:10.1111/imr.12941

Abstract:
B cells are critical mediators of humoral immune responses in the airways through antibody production, antigen presentation, and cytokine secretion. In addition, a subset of B cells, known as regulatory B cells (Bregs), exhibit immunosuppressive functions via diverse regulatory mechanisms. Bregs modulate immune responses via the secretion of IL‐10, IL‐35, and tumor growth factor‐β (TGF‐β), and by direct cell contact. The balance between effector and regulatory B cell functions is critical in the maintenance of immune homeostasis. The importance of Bregs in airway immune responses is emphasized by the different respiratory disorders associated with abnormalities in Breg numbers and function. In this review, we summarize the role of immunosuppressive Bregs in airway inflammatory diseases and highlight the importance of this subset in the maintenance of respiratory health. We propose that improved understanding of signals in the lung microenvironment that drive Breg differentiation can provide novel therapeutic avenues for improved management of respiratory diseases.
Daniel Michaud, Colleen R. Steward, Bhalchandra Mirlekar , Yuliya Pylayeva‐Gupta
Published: 23 December 2020
by Wiley
Immunological Reviews; doi:10.1111/imr.12939

The publisher has not yet granted permission to display this abstract.
Siyuan Ma, Pattraporn Satitsuksanoa, Kirstin Jansen, Lacin Cevhertas, Willem Van De Veen , Mubeccel Akdis
Published: 21 December 2020
by Wiley
Immunological Reviews; doi:10.1111/imr.12937

The publisher has not yet granted permission to display this abstract.
Kaitlin A. Read, Devin M. Jones, Aharon G. Freud , Kenneth J. Oestreich
Published: 17 December 2020
by Wiley
Immunological Reviews; doi:10.1111/imr.12936

The publisher has not yet granted permission to display this abstract.
Camille A. Spinner, Vanja Lazarevic
Published: 7 December 2020
by Wiley
Immunological Reviews; doi:10.1111/imr.12935

The publisher has not yet granted permission to display this abstract.
Keenan J. Wiggins, Christopher D Scharer
Published: 5 December 2020
by Wiley
Immunological Reviews; doi:10.1111/imr.12934

The publisher has not yet granted permission to display this abstract.
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