Cellular Physiology and Biochemistry

Journal Information
ISSN / EISSN : 10158987 / 14219778
Current Publisher: Cell Physiol Biochem Press GmbH and Co KG (10.33594)
Former Publisher: S. Karger AG (10.1159)
Total articles ≅ 5,931
Google Scholar h5-index: 52
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Cellular Physiology and Biochemistry; doi:10.33594/000000000

Showkat Ahmad Dar, Prem Prakash Srivastava, Tincy Varghese, Subodh Gupta, Gopal Krishna, Pallath Muhammed Nuzaiba, Tasok Leya
Cellular Physiology and Biochemistry, Volume 53, pp 851-864; doi:10.33594/000000177

Paul P.R. Iyyanar, Merlin P. Thangaraj, B. Frank Eames, Adil J. Nazarali
Cellular Physiology and Biochemistry, Volume 53, pp 832-850; doi:10.33594/000000176

Lydia Brandl, David Horst, Thomas G. P. Grünewald, Julia Mayerle, Andrea Sendelhofert, Jens Neumann, Thomas Kirchner, Enrico N. De Toni
Cellular Physiology and Biochemistry, Volume 53, pp 820-831; doi:10.33594/000000175

Yisun Jeong, Soo Youn Bae, Daeun You, Seung Pil Jung, Hee Jun Choi, Isaac Kim, Se Kyung Lee, Jonghan Yu, Seok Won Kim, Jeong Eon Lee, et al.
Cellular Physiology and Biochemistry, Volume 53, pp 805-819; doi:10.33594/000000174

Sara Soares Tozoni, Gabriela Ferreira Dias, Gabriela Bohnen, Nadja Grobe, Roberto Pecoits-Filho, Peter Kotanko, Andréa Novais Moreno-Amaral
Cellular Physiology and Biochemistry, Volume 53, pp 794-804; doi:10.33594/000000173

Abstract:Red blood cell (RBC) death could contribute to anemia in chronic kidney disease (CKD) patients. Recent observational research has suggested a relationship between RBC death (eryptosis) and hypoxemia in hemodialysis patients. Thus, we studied the isolated and joint effects of a uremic toxin (indoxyl sulfate; IS) and hypoxia on RBC biology. We incubated RBC from healthy donors with IS at concentrations of 0.01mM, 0.09mM and 0.17mM under both normoxic (21% O2) and hypoxic (5% O2) conditions for 24 hours. Eryptosis was evaluated by RBC phosphatidylserine (PS) exposure, cell volume, and cytosolic calcium which were quantified by Annexin-V+, forward scatter, and Fluo-3AM+ binding, respectively. RBC redox balance was reported by reactive oxygen species (ROS) production and intracellular reduced glutathione (GSH). Analyses were performed by flow cytometry. Hypoxia induced a 2-fold ROS production compared to normoxia. PS exposure and cytosolic calcium increased, while cell volume decreased by hypoxia and likewise by IS. IS increased ROS production in a dose-dependent manner under conditions of both normoxia and hypoxia. The same conditions promoted a GSH decrease with IS intensifying the hypoxia-induced effects. In summary, our results indicate that the concurrent presence of hypoxia and uremia augments RBC death and may therefore, contribute to the genesis of anemia in CKD.
Yan Yu, Anna Seidler, Kunyan Zhou, Zhenglin Yuan, Sunil Yeruva, Mahdi Amiri, Chris C. Yun, Katerina Nikolovska, Ursula Seidler
Cellular Physiology and Biochemistry, Volume 52, pp 1017-1038; doi:10.33594/0000000070

David Heinzmann, Karin Klingel, Karin Müller, Jörg Kumbrink, Thomas Kirchner, Jürgen Schreieck, Meinrad Gawaz, Peter Seizer
Cellular Physiology and Biochemistry, Volume 52, pp 435-438; doi:10.33594/000000031

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