The FASEB Journal

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ISSN / EISSN : 0892-6638 / 1530-6860
Published by: Wiley-Blackwell (10.1096)
Total articles ≅ 110,042
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Sergio Linsambarth, Francisco J. Carvajal, Rodrigo Moraga‐Amaro, Luis Mendez, Giovanni Tamburini, Ivanka Jimenez, Daniel Antonio Verdugo, Gonzalo I. Gómez, Nur Jury, Pablo Martínez, et al.
Published: 21 January 2022
The FASEB Journal, Volume 36; https://doi.org/10.1096/fj.202100798rr

The publisher has not yet granted permission to display this abstract.
, Jagannath Padmanabhan, , Dominic Henn, Chikage Noishiki, Artem A. Trotsyuk, Hudson C. Kussie, Melissa C. Leeolou, Noah J. Magbual, Sophia Andrikopoulos, et al.
Published: 20 January 2022
The FASEB Journal, Volume 36; https://doi.org/10.1096/fj.202101354

The publisher has not yet granted permission to display this abstract.
, Gabriel Spitzer, Christine Lehner, Andrea Wagner, Renate Gehwolf, Johann Fierlbeck, Nadja Weissenbacher, , Ludwig M. Heindl,
Published: 19 January 2022
The FASEB Journal, Volume 36; https://doi.org/10.1096/fj.202100773rrr

Abstract:
Vascular endothelial growth factor (VEGF) signaling is crucial for a large variety of cellular processes, not only related to angiogenesis but also in nonvascular cell types. We have previously shown that controlling angiogenesis by reducing VEGF-A signaling positively affects tendon healing. We now hypothesize that VEGF signaling in non-endothelial cells may contribute to tendon pathologies. By immunohistochemistry we show that VEGFR1, VEGFR2, and VEGFR3 are expressed in murine and human tendon cells in vivo. In a rat Achilles tendon defect model we show that VEGFR1, VEGFR3, and VEGF-D expression are increased after injury. On cultured rat tendon cells we show that VEGF-D stimulates cell proliferation in a dose-dependent manner; the specific VEGFR3 inhibitor SAR131675 reduces cell proliferation and cell migration. Furthermore, activation of VEGFR2 and -3 in tendon-derived cells affects the expression of mRNAs encoding extracellular matrix and matrix remodeling proteins. Using explant model systems, we provide evidence, that VEGFR3 inhibition prevents biomechanical deterioration in rat tail tendon fascicles cultured without load and attenuates matrix damage if exposed to dynamic overload in a bioreactor system. Together, these results suggest a strong role of tendon cell VEGF signaling in mediation of degenerative processes. These findings give novel insight into tendon cell biology and may pave the way for novel treatment options for degenerative tendon diseases.
Bailey D. Peck, Kevin A. Murach, R. Grace Walton, Alexander J. Simmons, Douglas E. Long, Kate Kosmac, Cory M. Dungan, Philip A. Kern, Marcas M. Bamman, Charlotte A. Peterson
Published: 19 January 2022
The FASEB Journal, Volume 36; https://doi.org/10.1096/fj.202100182rr

Abstract:
The extracellular matrix (ECM) in skeletal muscle plays an integral role in tissue development, structural support, and force transmission. For successful adaptation to mechanical loading, remodeling processes must occur. In a large cohort of older adults, transcriptomics revealed that genes involved in ECM remodeling, including matrix metalloproteinase 14 (MMP14), were the most upregulated following 14 weeks of progressive resistance exercise training (PRT). Using single-cell RNA-seq, we identified macrophages as a source of Mmp14 in muscle following a hypertrophic exercise stimulus in mice. In vitro contractile activity in myotubes revealed that the gene encoding cytokine leukemia inhibitory factor (LIF) is robustly upregulated and can stimulate Mmp14 expression in macrophages. Functional experiments confirmed that modulation of this muscle cell-macrophage axis facilitated Type I collagen turnover. Finally, changes in LIF expression were significantly correlated with MMP14 expression in humans following 14 weeks of PRT. Our experiments reveal a mechanism whereby muscle fibers influence macrophage behavior to promote ECM remodeling in response to mechanical loading.
, Zhenyu Lv, Miaomiao Guo, Chuanxin Sun, Xiaopeng Li, Zhenguo Jiang, Wanchang Zhang,
Published: 19 January 2022
The FASEB Journal, Volume 36; https://doi.org/10.1096/fj.202101116rr

The publisher has not yet granted permission to display this abstract.
Panagiota Agrafioti, Joshua Morin‐Baxter, Kranthi K. K. Tanagala, Sunil Dubey, Peter Sims, Evanthia Lalla,
Published: 15 January 2022
The FASEB Journal, Volume 36; https://doi.org/10.1096/fj.202101198r

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Chengfang Sun, Jingchao Wei, Zhilin Long, Weixi Zhao, Qi Huangfu, Qi Xie, ,
Published: 14 January 2022
The FASEB Journal, Volume 36; https://doi.org/10.1096/fj.202101310r

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, Atsushi Yamaguchi, Ken Suzuki
Published: 8 January 2022
The FASEB Journal, Volume 36; https://doi.org/10.1096/fj.202101428rr

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Na‐Ra Han, Phil‐Dong Moon, Sun‐Young Nam, Seong‐Gyu Ko, Hi‐Joon Park, ,
Published: 8 January 2022
The FASEB Journal, Volume 36; https://doi.org/10.1096/fj.202101447r

The publisher has not yet granted permission to display this abstract.
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