Alzheimer's & Dementia

Journal Information
ISSN / EISSN : 1552-5260 / 1552-5279
Current Publisher: Wiley (10.1002)
Former Publisher: Elsevier BV (10.1016) , Wiley (10.1016)
Total articles ≅ 38,590
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Jordan Bryan, Arpita Mandan, Gauri Kamat, W. Kirby Gottschalk, Alexandra Badea, Kendra J. Adams, J. Will Thompson, Carol A. Colton, Sayan Mukherjee, Michael W. Lutz , et al.
Published: 21 January 2021
by Wiley
Alzheimer's & Dementia; doi:10.1002/alz.12223

The publisher has not yet granted permission to display this abstract.
Hong‐Dong Li, Cory C. Funk, Karen McFarland, Eric B. Dammer, Mariet Allen, Minerva M. Carrasquillo, Yona Levties, Paramita Chakrabarty, Jeremy D. Burgess, Xue Wang, et al.
Published: 21 January 2021
by Wiley
Alzheimer's & Dementia; doi:10.1002/alz.12254

Abstract:
Intron retention (IR) has been implicated in the pathogenesis of complex diseases such as cancers; its association with Alzheimer's disease (AD) remains unexplored. We performed genome‐wide analysis of IR through integrating genetic, transcriptomic, and proteomic data of AD subjects and mouse models from the Accelerating Medicines Partnership‐Alzheimer's Disease project. We identified 4535 and 4086 IR events in 2173 human and 1736 mouse genes, respectively. Quantitation of IR enabled the identification of differentially expressed genes that conventional exon‐level approaches did not reveal. There were significant correlations of intron expression within innate immune genes, like HMBOX1, with AD in humans. Peptides with a high probability of translation from intron‐retained mRNAs were identified using mass spectrometry. Further, we established AD‐specific intron expression Quantitative Trait Loci, and identified splicing‐related genes that may regulate IR. Our analysis provides a novel resource for the search for new AD biomarkers and pathological mechanisms.
Hanzhang Lu, Amir H. Kashani, Konstantinos Arfanakis, Arvind Caprihan, Charles DeCarli, Brian T. Gold, Yang Li, Pauline Maillard, Claudia L. Satizabal, Lara Stables, et al.
Published: 21 January 2021
by Wiley
Alzheimer's & Dementia; doi:10.1002/alz.12216

The publisher has not yet granted permission to display this abstract.
Patrick H. Luckett , Austin McCullough, Brian A. Gordon, Jeremy Strain, Shaney Flores, Aylin Dincer, John McCarthy, Todd Kuffner, Ari Stern, Karin L. Meeker, et al.
Published: 21 January 2021
by Wiley
Alzheimer's & Dementia; doi:10.1002/alz.12259

The publisher has not yet granted permission to display this abstract.
Irina Kinchin , Eileen Mitchell, Meera Agar, Dominic Trépel
Published: 21 January 2021
by Wiley
Alzheimer's & Dementia; doi:10.1002/alz.12262

Abstract:
Introduction This review aims to systematically identify and appraise the methodological quality of claims on the cost of delirium; and discuss challenges and opportunities for improvements in the precision of the estimates. Methods Searches of scientific papers and gray literature were performed up until June 2020. The Larg and Moss checklist was used to assess the methodological quality of the included studies. Results After deduplication, the search identified 317 potentially relevant articles, of which 17 articles were eligible for inclusion. After adjusting for inflation and common currency, the cost of delirium ranged between $806 and $24,509 (in 2019 US$). Discussion This review found significant variation among the cost estimates and methodological quality. There has been limited focus on dementia as a sequela of delirium in terms of economic implications, but recent evidence suggests cost implications of delirium may be 52% higher when dementia is considered.
Donna Wilcock, Gregory Jicha, Deborah Blacker, Marilyn S. Albert, Lina M. D'orazio, Fanny M. Elahi, Myriam Fornage, Jason D. Hinman, Janice Knoefel, Joel Kramer, et al.
Published: 21 January 2021
by Wiley
Alzheimer's & Dementia; doi:10.1002/alz.12215

The publisher has not yet granted permission to display this abstract.
Jürgen Germann, Gavin J.B. Elias, Alexandre Boutet, Keshav Narang, Clemens Neudorfer, Andreas Horn, Aaron Loh, Wissam Deeb, Bryan Salvato, Leonardo Almeida, et al.
Published: 21 January 2021
by Wiley
Alzheimer's & Dementia; doi:10.1002/alz.12238

The publisher has not yet granted permission to display this abstract.
Michael J. C. Bray , Lisa N. Richey, Barry R. Bryant, Akshay Krieg, Sahar Jahed, William Tobolowsky, Christian LoBue, Matthew E. Peters
Published: 19 January 2021
by Wiley
Alzheimer's & Dementia; doi:10.1002/alz.12225

The publisher has not yet granted permission to display this abstract.
Puja Agarwal , Klodian Dhana, Lisa L. Barnes, Thomas M Holland, Yanyu Zhang, Denis A. Evans, Martha Clare Morris
Published: 7 January 2021
by Wiley
Alzheimer's & Dementia; doi:10.1002/alz.12277

The publisher has not yet granted permission to display this abstract.
Hong Bao, Yiming Liu, Mengguo Zhang, Zuolong Chen, Weiwei Zhang, Yuhao Ge, Dongmei Kang, Feng Gao , Yong Shen
Published: 7 January 2021
by Wiley
Alzheimer's & Dementia; doi:10.1002/alz.12276

The publisher has not yet granted permission to display this abstract.
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